4wot A 2.93 BS01 3SG A 1 I98 G101 F103 V106 A119 F136 E170 Y171 M172 D232 F384 I77 G80 F82 V85 A98 F115 E149 Y150 M151 D211 F360 D214 K216 N219 D232 T253 D193 K195 N198 D211 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=1.6nM O75116 25898023 501 AGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDVETFPIPKAFVGNQLPFIGFTYYR 4wot B 2.93 BS01 3SG B 1 I98 G101 F103 G104 V106 A119 F136 M172 D214 N219 D232 T235 F384 I77 G80 F82 G83 V85 A98 F115 M151 D193 N198 D211 T214 F363 D214 K216 N219 D232 T253 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 IC50=1.6nM O75116 25898023 501 AGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDGDVETFPIPKAFVGNQLPFIGFTYYR 4wot C 2.93 BS01 3SG C 1 G101 A102 F103 G104 V106 A119 F136 E170 M172 N219 L221 A231 D232 F384 G80 A81 F82 G83 V85 A98 F115 E149 M151 N198 L200 A210 D211 F363 D214 K216 N219 D232 T253 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 IC50=1.6nM O75116 25898023 501 AGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDVETFPIPKAFVGNQLPFIGFTYYR 4wot D 2.93 BS01 3SG D 1 I98 G101 F103 V106 A119 F136 M172 D232 V251 F384 I76 G79 F81 V84 A97 F114 M150 D210 V227 F360 D214 K216 N219 D232 T253 D192 K194 N197 D210 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=1.6nM O75116 25898023 501 GASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDVETFPIPKAFVGNQLPFIGFTYYR