3ril A 2.4 BS01 3RK A 1 D127 F128 W179 N234 E235 F246 E340 W381 D127 F128 W179 N234 E235 F246 E339 W380 E235 E340 C342 N370 E235 E339 C341 N369 2.4.1.-,3.2.1.-,3.2.1.45,3.2.1.46 0004336,0004348,0005102,0005124,0005515,0005615,0005764,0005765,0005783,0005794,0005802,0006665,0006678,0006680,0006914,0007005,0007040,0007417,0008203,0008340,0008422,0009267,0009268,0014004,0016020,0016241,0016757,0016787,0016798,0019882,0019915,0021694,0021859,0022904,0023021,0030259,0031175,0031333,0032006,0032436,0032715,0033077,0033574,0035307,0042391,0043161,0043202,0043243,0043407,0043524,0043627,0046512,0046513,0046527,0048469,0048854,0048872,0050295,0050728,0050877,0050905,0051246,0051248,0051402,0061436,0061518,0061744,0070062,0071356,0071425,0071548,0072676,0097066,0098773,1901805,1903052,1903061,1904457,1904925,1905037,1905165 ic50=146uM -logKd/Ki=3.84, IC50=146uM Ki=12800nM P04062 22047104 513 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 3ril B 2.4 BS01 3RK B 1 D127 F128 W179 N234 E235 E340 C342 W381 D127 F128 W179 N234 E235 E340 C342 W381 E235 E340 C342 N370 E235 E340 C342 N370 2.4.1.-,3.2.1.-,3.2.1.45,3.2.1.46 0004336,0004348,0005102,0005124,0005515,0005615,0005764,0005765,0005783,0005794,0005802,0006665,0006678,0006680,0006914,0007005,0007040,0007417,0008203,0008340,0008422,0009267,0009268,0014004,0016020,0016241,0016757,0016787,0016798,0019882,0019915,0021694,0021859,0022904,0023021,0030259,0031175,0031333,0032006,0032436,0032715,0033077,0033574,0035307,0042391,0043161,0043202,0043243,0043407,0043524,0043627,0046512,0046513,0046527,0048469,0048854,0048872,0050295,0050728,0050877,0050905,0051246,0051248,0051402,0061436,0061518,0061744,0070062,0071356,0071425,0071548,0072676,0097066,0098773,1901805,1903052,1903061,1904457,1904925,1905037,1905165 ic50=146uM -logKd/Ki=3.84, IC50=146uM Ki=12800nM P04062 22047104 509 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 3ril C 2.4 BS01 3RK C 1 D127 F128 W179 E235 F246 Y313 E340 C342 W381 D127 F128 W179 E235 F246 Y313 E339 C341 W380 E235 E340 C342 N370 E235 E339 C341 N369 2.4.1.-,3.2.1.-,3.2.1.45,3.2.1.46 0004336,0004348,0005102,0005124,0005515,0005615,0005764,0005765,0005783,0005794,0005802,0006665,0006678,0006680,0006914,0007005,0007040,0007417,0008203,0008340,0008422,0009267,0009268,0014004,0016020,0016241,0016757,0016787,0016798,0019882,0019915,0021694,0021859,0022904,0023021,0030259,0031175,0031333,0032006,0032436,0032715,0033077,0033574,0035307,0042391,0043161,0043202,0043243,0043407,0043524,0043627,0046512,0046513,0046527,0048469,0048854,0048872,0050295,0050728,0050877,0050905,0051246,0051248,0051402,0061436,0061518,0061744,0070062,0071356,0071425,0071548,0072676,0097066,0098773,1901805,1903052,1903061,1904457,1904925,1905037,1905165 ic50=146uM Ki=12800nM P04062 22047104 513 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ 3ril D 2.4 BS01 3RK D 1 D127 F128 W179 N234 E235 Y313 E340 W381 D127 F128 W179 N234 E235 Y313 E340 W381 E235 E340 C342 N370 E235 E340 C342 N370 2.4.1.-,3.2.1.-,3.2.1.45,3.2.1.46 0004336,0004348,0005102,0005124,0005515,0005615,0005764,0005765,0005783,0005794,0005802,0006665,0006678,0006680,0006914,0007005,0007040,0007417,0008203,0008340,0008422,0009267,0009268,0014004,0016020,0016241,0016757,0016787,0016798,0019882,0019915,0021694,0021859,0022904,0023021,0030259,0031175,0031333,0032006,0032436,0032715,0033077,0033574,0035307,0042391,0043161,0043202,0043243,0043407,0043524,0043627,0046512,0046513,0046527,0048469,0048854,0048872,0050295,0050728,0050877,0050905,0051246,0051248,0051402,0061436,0061518,0061744,0070062,0071356,0071425,0071548,0072676,0097066,0098773,1901805,1903052,1903061,1904457,1904925,1905037,1905165 ic50=146uM Ki=12800nM P04062 22047104 509 ARPCIPKSFGYSSVVCVCNATYCDSFDPPTFPALGTFSRYESTRSGRRMELSMGPIQANHTGTGLLLTLQPEQKFQKVKGFGGAMTDAAALNILALSPPAQNLLLKSYFSEEGIGYNIIRVPMASCDFSIRTYTYADTPDDFQLHNFSLPEEDTKLKIPLIHRALQLAQRPVSLLASPWTSPTWLKTNGAVNGKGSLKGQPGDIYHQTWARYFVKFLDAYAEHKLQFWAVTAENEPSAGLLSGYPFQCLGFTPEHQRDFIARDLGPTLANSTHHNVRLLMLDDQRLLLPHWAKVVLTDPEAAKYVHGIAVHWYLDFLAPAKATLGETHRLFPNTMLFASEACVGSKFWEQSVRLGSWDRGMQYSHSIITNLLYHVVGWTDWNLALNPEGGPNWVRNFVDSPIIVDITKDTFYKQPMFYHLGHFSKFIPEGSQRVGLVASQKNDLDAVALMHPDGSAVVVVLNRSSKDVPLTIKDPAVGFLETISPGYSIHTYLWHRQ