4wnp A 1.88 BS01 3RJ A 1 I22 A44 M92 E93 Y94 C95 G98 Q142 N143 L145 I16 A38 M86 E87 Y88 C89 G92 Q136 N137 L139 D138 K140 Q142 N143 D165 S184 D132 K134 Q136 N137 D159 S178 2.7.11.1 0004672,0004674,0005524,0006468,0010506 ic50=8nM -logKd/Ki=8.10, IC50=8nM O75385 25551253 303 GTETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDA 4wnp B 1.88 BS01 3RJ B 1 I22 A44 Y94 C95 G98 Q142 N143 L145 I15 A37 Y87 C88 G91 Q135 N136 L138 D138 K140 Q142 N143 D165 S184 D131 K133 Q135 N136 D158 S177 2.7.11.1 0004672,0004674,0005524,0006468,0010506 ic50=8nM O75385 25551253 401 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDA 4wnp C 1.88 BS01 3RJ C 1 I22 A44 E93 Y94 C95 G98 Q142 N143 L145 I15 A37 E86 Y87 C88 G91 Q135 N136 L138 D138 K140 Q142 N143 D165 S184 D131 K133 Q135 N136 D158 S177 2.7.11.1 0004672,0004674,0005524,0006468,0010506 ic50=8nM O75385 25551253 401 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLD 4wnp D 1.88 BS01 3RJ D 1 I22 A44 K46 E93 Y94 C95 G98 N143 L145 I15 A37 K39 E86 Y87 C88 G91 N136 L138 D138 K140 Q142 N143 D165 S184 D131 K133 Q135 N136 D158 S177 2.7.11.1 0004672,0004674,0005524,0006468,0010506 ic50=8nM O75385 25551253 401 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDA 6u5l A 1.75 BS01 3RJ A 1 I10 R12 V18 A31 L33 W46 V75 C78 G81 L128 I12 R14 V20 A33 L35 W48 V77 C80 G83 L130 D121 S123 K126 N139 S174 S182 D123 S125 K128 N141 S165 S173 2.7.11.1 0004672,0005524,0006468 Q96C45 31841327 301 SGMENFILYEEIGRGSKTVVYKGRRKGTINFVAILCTDKCKRPEITNWVRLTREIKHKNIVTFHEWYETSNHLWLVVELCTGGSLKTVIAQDENLPEDVVREFGIDLISGLHHLHKLGILFCDISPRKILLEGPGTLKFSNFCLAKVEGENLEEFFALVAAEEASMKSRVKGSPVYTAPEVVRGADFSISSDLWSLGCLLYEMFSGKPPFFSESISELTEKILCEDPLPPIPKDSSRPKASSDFINLLDGLLQRDPQKRLTWTRLLQHSFWKKAFA