3rhx A 2.01 BS01 3RH A 1 V492 A512 E531 V561 Y563 A564 L630 V29 A49 E68 V98 Y100 A101 L155 D623 A625 R627 N628 D641 D148 A150 R152 N153 D166 2.7.10.1 0004672,0004713,0005007,0005524,0006468 ic50=0.84uM IC50=840nM P11362 21454610 2 ELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQ 3rhx B 2.01 BS01 3RH B 1 V492 A512 V561 Y563 A564 L630 V32 A48 V97 Y99 A100 L150 D623 A625 R627 N628 D641 D143 A145 R147 N148 D161 2.7.10.1 0004672,0004713,0005007,0005524,0006468 ic50=0.84uM -logKd/Ki=6.08, IC50=0.84uM IC50=840nM P11362 21454610 1 SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLADYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALT 3ri1 A 2.1 BS01 3RH A 1 V495 A515 K517 M538 V564 A567 L633 V28 A48 K50 M71 V97 A100 L153 D626 A628 R630 N631 D644 D146 A148 R150 N151 D164 2.7.10.1 0004672,0004713,0005524,0006468 Kd=5uM -logKd/Ki=5.30, Kd=5uM IC50=1230nM P21802 21454610 2 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 3ri1 B 2.1 BS01 3RH B 1 V495 A515 K517 M538 V564 A567 L633 V28 A45 K47 M68 V94 A97 L150 D626 A628 R630 N631 D644 D143 A145 R147 N148 D161 2.7.10.1 0004672,0004713,0005524,0006468 Kd=5uM IC50=1230nM P21802 21454610 1 LPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTN