3qvv A 2.35 BS02 3QV A 1 F81 F84 K106 H108 V148 I247 F74 F77 K99 H101 V141 I240 K48 H108 S138 K41 H101 S131 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 Ki=38uM -logKd/Ki=4.42, Ki=38uM P50225 21723874 296 SRQPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFNRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPDPGTWDSFLEKFMVGEVCYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTIPQEIMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL 3qvv B 2.35 BS02 3QV B 1 F81 K106 H108 V148 F74 K99 H101 V141 K48 H108 S138 K41 H101 S131 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 Ki=38uM P50225 21723874 296 SRQPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFNRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPDPGTWDSFLEKFMVGEVCYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTIPQEIMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL 3u3m A 2.3 BS02 3QV A 1 F81 K106 H108 F142 V148 F247 M248 F75 K100 H102 F136 V142 F241 M242 K48 H108 S138 K42 H102 S132 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 P50225 22069470 297 TSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL 3u3o A 2.0 BS01 3QV A 1 F81 F84 K106 H108 F142 V148 M248 F74 F77 K99 H101 F135 V141 M241 K48 H108 S138 K41 H101 S131 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 P50225 22069470 296 SRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL 3u3o A 2.0 BS02 3QV A 2 F76 M77 F84 I89 P244 F69 M70 F77 I82 P237 K48 H108 S138 K41 H101 S131 2.8.2.1 0004062,0005515,0005737,0005829,0006068,0006584,0006805,0008146,0008202,0008210,0009308,0009812,0016740,0047894,0050294,0050427,0050656,0051923 P50225 22069470 297 SRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGHSLPEETVDFMVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL