3p3c A 1.25 BS02 3P3 A 1 I18 H58 E73 H74 T179 F180 I186 I189 G198 S199 H226 K227 D230 H253 I17 H57 E72 H73 T178 F179 I185 I188 G197 S198 H225 K226 D229 H252 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 Kd=8nM, Ki=1nM O67648 21167751 501 GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFAFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQKLTRDL 3p3e A 1.28 BS03 3P3 A 1 M62 E77 T190 F191 I197 R201 G209 S210 V211 H237 D241 H264 M62 E77 T190 F191 I197 R201 G209 S210 V211 H237 D241 H264 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 Kd=8.35nM P47205 21167751 501 MIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYM 3p3g A 1.65 BS02 3P3 A 1 L62 C63 E78 H79 T191 M195 I198 G210 S211 F212 A215 H238 D242 H265 L62 C63 E78 H79 T191 M195 I198 G210 S211 F212 A215 H238 D242 H265 0008759,0009245 Ki=0.18nM -logKd/Ki=9.74, Ki=180pM 21167751 401 MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP 4fw4 A 2.19 BS02 3P3 A 1 E77 H78 T190 F191 I197 G209 S210 H237 D241 H264 E78 H79 T191 F192 I198 G210 S211 H238 D242 H265 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 Kd=8.35nM P47205 301 AMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP 4fw4 B 2.19 BS02 3P3 B 1 E77 H78 T190 F191 I197 G209 S210 H237 D241 H264 E78 H79 T191 F192 I198 G210 S211 H238 D242 H265 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 Kd=8.35nM P47205 302 AMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP 4fw4 C 2.19 BS02 3P3 C 1 M62 E77 H78 T190 F191 I197 R201 G209 S210 H237 D241 H264 M65 E80 H81 T193 F194 I200 R204 G212 S213 H240 D244 H267 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 Kd=8.35nM P47205 302 SNAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP 4fw4 D 2.19 BS02 3P3 D 1 M62 E77 H78 T190 F191 I197 G209 S210 H237 D241 H264 M65 E80 H81 T193 F194 I200 G212 S213 H240 D244 H267 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 Kd=8.35nM P47205 302 SNAMIKQRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRTDLDPVVEIPARAENVGETTMSTTLVKGDVKVDTVEHLLSAMAGLGIDNAYVELSASEVPIMDGSAGPFVFLIQSAGLQEQEAAKKFIRIKREVSVEEGDKRAVFVPFDGFKVSFEIDFDHPVFRGRTQQASVDFSSTSFVKEVSRARTFGFMRDIEYLRSQNLALGGSVENAIVVDENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIGEFRGFKSGHALNNQLLRTLIADKDAWEVVTFEDARTAPISYMRP