3nga A 2.71 BS01 3NG A 1 L45 G46 V53 V66 K68 F113 H115 V116 H160 I174 D175 L44 G45 V52 V65 K67 F112 H114 V115 H159 I173 D174 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=8.00, Kd=10nM IC50=2000nM, Kd=0.562341nM, Ki=0.380000nM P68400 21093442 1000 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 3nga B 2.71 BS01 3NG B 1 L45 G46 V53 V66 K68 F113 H115 V116 H160 I174 D175 L44 G45 V52 V65 K67 F112 H114 V115 H159 I173 D174 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 IC50=2000nM, Kd=0.562341nM, Ki=0.380000nM P68400 21093442 1000 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 3pe1 A 1.6 BS01 3NG A 1 L45 G46 V53 V66 K68 F113 V116 H160 M163 I174 D175 L43 G44 V51 V64 K66 F111 V114 H158 M161 I172 D173 D156 K158 N161 D175 P184 S194 D154 K156 N159 D173 P182 S192 2.7.11.1 0004672,0004674,0005524,0006468 Ki=0.223nM -logKd/Ki=9.65, Ki=0.223nM IC50=2000nM, Kd=0.562341nM, Ki=0.380000nM P68400 21870818 338 GPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVK 5o11 A 2.4 BS01 3NG A 1 L44 G45 S46 V52 A65 K67 R122 L174 I185 D186 L11 G12 S13 V17 A30 K32 R87 L139 I150 D151 D167 K169 N172 D186 L193 T204 D132 K134 N137 D151 L158 T169 2.7.11.1 0004672,0004674,0005515,0005524,0005634,0005654,0005730,0005737,0005829,0005886,0006338,0006468,0006915,0008134,0016310,0022898,0030145,0043024,0043066,0043433,0044024,0045824,0045893,0046777,0046872,0050821,0060045,0070561,0071346,0090336,0106310,1902033,1904263,1905062,1990748 ic50=0.216uM -logKd/Ki=6.67, IC50=0.216uM IC50=48nM P11309 29042609 401 LESQYQVGPLLGSGGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH 6fyl A 1.95 BS01 3NG A 1 L169 G170 E171 F174 V177 A191 K193 F243 L246 L297 V326 D327 L26 G27 E28 F31 V34 A48 K50 F100 L103 L154 V183 D184 2.7.12.1 0004672,0005524,0006468 ic50=7nM -logKd/Ki=8.15, IC50=7nM IC50=4.0nM P49760 29985556 501 EDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLR 6fyp A 2.29 BS01 3NG A 1 L162 G163 E164 F167 V170 A184 K186 V220 F236 L239 N242 L290 D320 L28 G29 E30 F33 V36 A50 K52 V86 F102 L105 N108 L156 D186 2.7.12.1 0004672,0005524,0006468 ic50=143nM -logKd/Ki=6.84, IC50=143nM IC50=41nM P49761 29985556 501 SVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSF 6fyv A 2.46 BS01 3NG A 1 L167 G168 E169 F172 V175 A189 K191 F241 L244 L295 V324 D325 L18 G19 E20 F23 V26 A40 K42 F92 L95 L146 V172 D173 D288 K290 N293 D325 T342 D139 K141 N144 D173 T190 2.7.12.1 0004672,0005524,0006468 ic50=11nM -logKd/Ki=7.96, IC50=11nM Q9HAZ1 29985556 501 ICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLK 6hmb A 1.04 BS01 3NG A 1 L46 G47 V54 V67 K69 F114 Y116 I117 H161 M164 I175 D176 L40 G41 V48 V61 K63 F108 Y110 I111 H155 M158 I169 D170 D157 K159 N162 D176 S195 D151 K153 N156 D170 S189 2.7.11.1 0000785,0001669,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005829,0005956,0006302,0006338,0006468,0006915,0007283,0016055,0016310,0021987,0031519,0032435,0044024,0051726,0097421,0106310,1901524,1903955,1905818,2001234 IC50=0.300000nM, Ki=0.220000nM P19784 31559376 413 GSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ 6isj A 2.3 BS01 3NG A 1 V44 G45 R46 I65 K67 V115 M162 I173 D174 V39 G40 R41 I60 K62 V108 M155 I166 D167 D155 K157 N160 D174 S193 D148 K150 N153 D167 S186 0004672,0004674,0005524,0006468 401 SVARVYANVNEKLGRSWWDYDNLVVQWGVQDNYEIVRKVGRGKYSEVFESIHLPTDSKCIVKVLKKKKKIKREIKILQNLAGGPNVVGLLDVVRDSQSKTPSIVTEYVNNTEFKTLYPKFSDFDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRTLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNADQLVKIAKVLGTDELYTYLERYDIDLDAQFDDILGRYPRKPWSRFVSSENQRYISSEAIDFLDKLLRYDHQERLTAEEAKEHPYFEPVRQAAA 6k3l B 2.09 BS01 3NG B 1 G45 R46 V52 I65 K67 T112 Y114 V115 M162 I173 D174 G41 R42 V48 I61 K63 T108 Y110 V111 M158 I169 D170 D155 K157 N160 D174 S193 D151 K153 N156 D170 S189 2.7.11.1 0004672,0004674,0005524,0005634,0005829,0005956,0006356,0006359,0006468,0006974,0016310,0018105,0018107,0043231,0046872,0051726,0106310 Kd=60.1nM J9VNH4 31591414 401 RSVARVYANVNEKLGRSWWDYDNLVVQWGVQDNYEIVRKVGRGKYSEVFESIHLPTDSKCIVKVLKPVKKKKIKREIKILQNLAGGPNVVGLLDVVRDSQSKTPSIVTEYVNNTEFKTLYPKFSDFDVRYYIFELLKALDFCHSKGIMHRDVKPHNVMIDHEKRTLRLIDWGLAEFYHPGTEYNVRVASRYFKGPELLVDFQEYDYSLDMWSLGCMFASMIFRKEPFFHGHDNADQLVKIAKVLGTDELYTYLERYDIDLDAQFDDILGRYPRKPWSRFVSSENQRYISSEAIDFLDKLLRYDHQERLTAEEAKEHPYFEPVRQAAAQA 6khd A 2.7 BS01 3NG A 1 L167 G168 E169 F172 V175 A189 K191 F241 L244 L295 V324 L19 G20 E21 F24 V27 A41 K43 F93 L96 L147 V167 D288 K290 N293 D325 D140 K142 N145 D168 2.7.12.1 0004672,0004674,0004712,0004713,0004715,0005515,0005524,0005634,0006468,0016310,0043484,0106310 P49759 31531359 1000 LICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEERTLINPDIKVVDFGSATYDDEHHSTLVRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLK 6khd B 2.7 BS01 3NG B 1 L167 G168 E169 V175 K191 F241 L243 L244 L295 V324 D325 L19 G20 E21 V27 K43 F93 L95 L96 L147 V174 D175 D288 K290 N293 D325 T342 D140 K142 N145 D175 T192 2.7.12.1 0004672,0004674,0004712,0004713,0004715,0005515,0005524,0005634,0006468,0016310,0043484,0106310 P49759 31531359 1000 LICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKK 6khd C 2.7 BS01 3NG C 1 L167 G168 E169 F172 V175 A189 K191 F241 E242 L244 L295 V324 L18 G19 E20 F23 V26 A40 K42 F92 E93 L95 L146 V170 D288 K290 N293 D325 T342 D139 K141 N144 D171 T188 2.7.12.1 0004672,0004674,0004712,0004713,0004715,0005515,0005524,0005634,0006468,0016310,0043484,0106310 P49759 31531359 1000 ICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRACKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 6khe A 2.8 BS01 3NG A 1 L169 G170 E171 V177 A191 K193 F243 E244 L245 L246 L297 V326 D327 L26 G27 E28 V34 A48 K50 F100 E101 L102 L103 L154 V183 D184 2.7.12.1 0004672,0004674,0004712,0004713,0005515,0005524,0005634,0005654,0006468,0010212,0016310,0016604,0016607,0042802,0043484,0045721,0046777,0106310 IC50=4.0nM P49760 31531359 1000 EDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAE 6khf A 2.598 BS01 3NG A 1 G163 E164 V170 A184 K186 F236 L238 L239 L290 D320 G22 E23 V29 A43 K45 F95 L97 L98 L149 D166 2.7.12.1 0001669,0003723,0004672,0004674,0004712,0004713,0005515,0005524,0005634,0005654,0005737,0006468,0016020,0016310,0016607,0031410,0042802,0043484,0045111,0106310 IC50=41nM P49761 31531359 1000 GHLVCRIGDWLQEDYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERS 6p5s A 2.194 BS01 3NG A 1 G206 R207 K228 F277 M279 L280 M331 I345 D346 G22 R23 K41 F81 M83 L84 M135 I149 D150 D324 K326 N329 D346 S364 D128 K130 N133 D150 S162 2.7.11.1 0004672,0005524,0006468 Q9H2X6 31341017 601 QLVQHEVLCSMTNTYEVLEFLGRGQVVKCWKRGTNEIVAIKILRQGQIEVSILARLSTESADDYNFVRAYECFQHHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDF 7z1f A 3.0 BS01 3NG A 1 I62 G63 F67 A83 K85 Y134 V135 L188 C199 D200 I35 G36 F40 A56 K58 Y105 V106 L159 C170 D171 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 401 VSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARENL 7z1f B 3.0 BS01 3NG B 1 F67 K85 Y134 V135 L188 C199 D200 F29 K41 Y73 V74 L127 C138 D139 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 401 TTVVATPGQGPDRPQEVSYTDTKIGNGSFGVVYQGELVAIKKVLQNRELQIMRKLDHCNIVRLRYFLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHA 7z1g A 2.85 BS01 3NG A 1 I62 G63 N64 V70 A83 K85 V110 Y134 V135 L188 C199 D200 I36 G37 N38 V44 A57 K59 V84 Y106 V107 L160 C171 D172 2.7.11.1,2.7.11.26 0004672,0005524,0006468 P49841 401 KVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARE 7z5n A 2.77 BS01 3NG A 1 I165 G166 K167 F170 V173 A186 K188 F238 M240 L241 L294 V306 D307 I31 G32 K33 F36 V39 A52 K54 F104 M106 L107 L160 V172 D173 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n B 2.77 BS01 3NG B 1 I165 G166 K167 V173 A186 K188 F238 E239 M240 L241 L294 V306 D307 I31 G32 K33 V39 A52 K54 F104 E105 M106 L107 L160 V172 D173 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n C 2.77 BS01 3NG C 1 I165 G166 K167 F170 V173 K188 F238 E239 M240 L241 L294 V306 D307 I32 G33 K34 F37 V40 K55 F105 E106 M107 L108 L161 V173 D174 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n D 2.77 BS01 3NG D 1 I165 G166 K167 V173 A186 K188 F238 E239 M240 L241 L294 V306 D307 I31 G32 K33 V39 A52 K54 F104 E105 M106 L107 L160 V172 D173 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKEYKPPGTRKLHNILGVETGGPGGRGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n E 2.77 BS01 3NG E 1 I165 G166 F170 V173 K188 F238 M240 L241 V306 D307 I31 G32 F36 V39 K54 F104 M106 L107 V172 D173 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKEYKPPGTRKLHNILGVETGGPGGRRASGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n F 2.77 BS01 3NG F 1 I165 G166 K167 V173 A186 K188 F238 E239 M240 L241 L294 V306 D307 I31 G32 K33 V39 A52 K54 F104 E105 M106 L107 L160 V172 D173 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n G 2.77 BS01 3NG G 1 I165 G166 V173 A186 K188 V222 F238 E239 M240 L241 V306 D307 I29 G30 V37 A50 K52 V82 F98 E99 M100 L101 V166 D167 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 NDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n H 2.77 BS01 3NG E 1 V180 Q182 V46 Q48 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQYIQSRFYRSPEVLMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPREYKPPGTRKLHNILGVETGGPGGRRASGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 7z5n H 2.77 BS02 3NG H 1 I165 G166 K167 V173 K188 V222 F238 E239 M240 L241 V306 D307 I31 G32 K33 V39 K54 V88 F104 E105 M106 L107 V172 D173 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 501 VYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQYIQSRFYRSPEVLMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPREYKPPGTRKLHNILGVETGGPGGRRASGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 8qbu A 1.09 BS02 3NG A 1 L46 G47 V54 V67 K69 F114 Y116 I117 M164 I175 D176 L41 G42 V49 V62 K64 F109 Y111 I112 M159 I170 D171 2.7.11.1 0000785,0001669,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005829,0005956,0006302,0006338,0006468,0006915,0007283,0016055,0016310,0021987,0031519,0032435,0044024,0051726,0097421,0106310,1901524,1903955,1905818,2001234 P19784 405 AGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQS 8w4q A 1.55 BS02 3NG A 1 H160 M273 M357 Q369 F372 H73 M186 M270 Q282 F285 3.1.4.53 0004114,0007165,0008081 Q08499 37918035 503 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP 8w4q B 1.55 BS02 3NG B 1 H160 M273 M357 Q369 F372 H73 M186 M270 Q282 F285 3.1.4.53 0004114,0007165,0008081 Q08499 37918035 503 QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIP