2qw1 A 1.7 BS01 3MG A 1 H152 W183 N211 D236 H151 W182 N210 D235 ? 0005509,0006935,0015757,0015765,0016020,0030246,0030288,0042597,0046872,0055052 Ki=125uM -logKd/Ki=3.90, Ki=125uM P0AEE5 19348466 310 DTRIGVTIYKYDDNFMSVVRKAIEQDAKAAPDVQLLMNDSQNDQSKQNDQIDVLLAKGVKALAINLVDPAAAGTVIEKARGQNVPVVFFNKEPSRKALDSYDKAYYVGTDSKESGIIQGDLIAKHWAANQGWDLNKDGQIQFVLLKGEPGHPDAEARTTYVIKELNDKGIKTEQLQLDTAMWDTAQAKDKMDAWLSGPNANKIEVVIANNDAMAMGAVEALKAHNKSSIPVFGVDALPEALALVKSGALAGTVLNDANNQAKATFDLAKNLADGKGAADGTNWKIDNKVVRVPYVGVDKDNLAEF 6rg2 A 1.12 BS01 3MG A 1 G78 K79 G100 T101 W106 W120 G52 K53 G74 T75 W80 W94 ? Kd=11.2mM Q7N8I8 32559333 401 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 A 1.12 BS02 3MG A 2 R93 E95 H107 W109 W165 R67 E69 H81 W83 W139 ? Kd=11.2mM Q7N8I8 32559333 403 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 A 1.12 BS03 3MG A 3 G173 V174 G195 T196 D197 W201 W216 G147 V148 G169 T170 D171 W175 W190 ? Kd=11.2mM Q7N8I8 32559333 404 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 A 1.12 BS05 3MG A 4 R188 E190 H202 W204 W261 R162 E164 H176 W178 W235 ? Kd=11.2mM Q7N8I8 32559333 407 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 A 1.12 BS07 3MG A 5 G317 T318 G339 T340 W345 W357 G291 T292 G313 T314 W319 W329 ? Kd=11.2mM Q7N8I8 32559333 410 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 A 1.12 BS08 3MG A 6 R284 E286 H298 Q349 W354 R258 E260 H272 Q323 W326 ? Kd=11.2mM Q7N8I8 32559333 411 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 A 1.12 BS09 3MG A 7 G51 T52 W57 W73 G362 S363 G25 T26 W31 W47 G334 S335 ? Kd=11.2mM Q7N8I8 32559333 412 AAIALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQASWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS02 3MG B 1 G78 K79 G100 T101 D102 W106 W120 G50 K51 G72 T73 D74 W78 W92 ? Kd=11.2mM Q7N8I8 32559333 402 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS04 3MG B 2 R93 E95 H107 W109 Q121 W165 R65 E67 H79 W81 Q93 W137 ? Kd=11.2mM Q7N8I8 32559333 404 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS05 3MG B 3 G173 V174 G195 T196 W201 G145 V146 G167 T168 W173 ? Kd=11.2mM Q7N8I8 32559333 405 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS07 3MG B 4 G221 V222 G243 S244 N245 Y249 W264 G193 V194 G215 S216 N217 Y221 W236 ? Kd=11.2mM Q7N8I8 32559333 407 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS08 3MG B 5 R188 E190 H202 W204 W261 R160 E162 H174 W176 W233 ? Kd=11.2mM Q7N8I8 32559333 408 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS09 3MG B 6 R284 E286 H298 Q349 W354 R256 E258 H270 Q321 W326 ? Kd=11.2mM Q7N8I8 32559333 411 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rg2 B 1.12 BS10 3MG B 7 G51 T52 W57 W73 G362 S363 G23 T24 W29 W45 G334 S335 ? Kd=11.2mM Q7N8I8 32559333 412 IALSEIVSVVNTSDGRIEVFGVGTDNAVWHNRQTAPHSGSSWTGWISLNGKVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGTITSNPAVYVNTDGRIDVFARGTDNALWHISQTAAHSGPWSSWQSLNGVITSNPAVHINSDGRLEVFARGTDNALWHIWQTAPDSNQWSGWDSLGGVITSDPVVIGTADGRLEVFARGSNNALYHIWQTVPHGGPWSNWASLNGVITSAPAVVKNSDGRLEVFARGTNNALYHIWQTVSHSGPWSNWATLNGTITSAPTAVEDADGRLEVFARGTDNALWNIWQATPSWSAWVSLKGSLIDASAIK 6rgu A 1.75 BS01 3MG A 1 G76 Q77 G98 T99 W104 W118 G52 Q53 G74 T75 W80 W94 ? 0046872 Kd=14.1mM C7BLE4 32559333 401 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS02 3MG A 2 R91 E93 H105 W107 G161 W163 R67 E69 H81 W83 G137 W139 ? 0046872 Kd=14.1mM C7BLE4 32559333 402 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS03 3MG A 3 G171 V172 G193 T194 W199 W214 G147 V148 G169 T170 W175 W190 ? 0046872 Kd=14.1mM C7BLE4 32559333 403 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS04 3MG A 4 G219 I220 G241 A242 D243 W247 G195 I196 G217 A218 D219 W223 ? 0046872 Kd=14.1mM C7BLE4 32559333 404 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS05 3MG A 5 R186 E188 H200 W202 W259 R162 E164 H176 W178 W235 ? 0046872 Kd=14.1mM C7BLE4 32559333 405 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS06 3MG A 6 G315 V316 G337 T338 W343 W355 G291 V292 G313 T314 W319 W331 ? 0046872 Kd=14.1mM C7BLE4 32559333 406 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS07 3MG A 7 R282 E284 H296 Q347 W352 R258 E260 H272 Q323 W328 ? 0046872 Kd=14.1mM C7BLE4 32559333 407 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6rgu A 1.75 BS08 3MG A 8 T50 W55 W71 G360 V361 T26 W31 W47 G336 V337 ? 0046872 Kd=14.1mM C7BLE4 32559333 408 STIALSEIVSVVNTSDGRLEVFGVGTDKAVWHNRQMAPHTGSPWSGWSSLKGQVTSKPVVYINTDGRLEVFARGTDNALWHIWQTATNAGWSNWQSLGGVITSNPAIYANTDGRLEVFARGADNALWHISQTTAHSGPWSSWASLNGVITSNPTVHINSDGRLEVFARGTDNALWHIWQTAPDSNLWSSWESLNGIITSDPVVIDTADGRLEVFARGADNALWHIWQTISHSGPWSGWQSLNGVITSAPAVAKNCDNRLEAFARGTDNALWHTWQTVSHSGPWSSWQSLNGVITSAPTAVRDADGRLEVFARGTDNALWLTWQTASSWSPWISLGGVLIDASAIK 6x9m A 1.0 BS05 3MG A 1 D110 D111 Q156 G157 G158 D159 D101 D102 Q147 G148 G149 D150 ? A1YIY3 33824212 1007 PDSLFAGLVGEYYGTNSQLNNISDFRALVDSKEADATFEAANISYGRGSSDVAKGTHLQEFLGSDASTLSTDPGDNTDGGIYLQGYVYLEAGTYNFKVTADDGYEITINGNPVATVDNNQSVYTVTHASFTISESGYQAIDMIWWDQGGDYVFQPTLSADGGSTYFVLDSAILSSTGETPYT