4ran A 2.549 BS01 3L6 A 1 D137 T138 G139 T141 K165 F186 V187 D193 D121 T122 G123 T125 K149 F170 V171 D177 E133 D134 D137 F186 R199 E117 D118 D121 F170 R183 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 -logKd/Ki=7.15, Ki=0.07uM P00492 25494538 301 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4ran B 2.549 BS01 3L6 B 1 D137 T138 G139 T141 K165 F186 V187 D193 D120 T121 G122 T124 K148 F169 V170 D176 E133 D134 D137 F186 R199 E116 D117 D120 F169 R182 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4ran C 2.549 BS01 3L6 C 1 L101 I135 D137 T138 G139 T141 K165 F186 V187 D193 L98 I120 D122 T123 G124 T126 K150 F171 V172 D178 E133 D134 D137 F186 R199 E118 D119 D122 F171 R184 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4ran D 2.549 BS01 3L6 D 1 D137 T138 G139 T141 K165 F186 V187 D193 D116 T117 G118 T120 K144 F165 V166 D172 E133 D134 D137 F186 R199 E112 D113 D116 F165 R178 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLVIGGLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 6apu A 1.842 BS02 3L6 A 1 I115 D117 T118 A119 T121 K145 F166 V167 I93 D95 T96 A97 T99 K123 F144 V145 E113 D114 D117 F166 R179 E91 D92 D95 F144 R157 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Ki=13.46uM Q07010 29481567 307 CKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRASSYDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKEL 6apu B 1.842 BS01 3L6 B 1 I115 D117 T118 A119 T121 K145 F166 V167 D173 I90 D92 T93 A94 T96 K120 F141 V142 D148 E113 D114 D117 F166 R179 E88 D89 D92 F141 R154 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Ki=13.46uM -logKd/Ki=4.87, Ki=13.46uM Q07010 29481567 305 ACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELERR