4rad A 2.0 BS01 3L5 A 1 I135 D137 T138 G139 T141 K165 F186 V187 I118 D120 T121 G122 T124 K148 F166 V167 E133 D134 D137 F186 R199 E116 D117 D120 F166 R179 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 -logKd/Ki=7.10, Ki=0.08uM P00492 25494538 301 PGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad B 2.0 BS01 3L5 B 1 I135 D137 T138 G139 T141 K165 F186 V187 I125 D127 T128 G129 T131 K155 F176 V177 E133 D134 D137 F186 R199 E123 D124 D127 F176 R189 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad C 2.0 BS01 3L5 C 1 K68 I135 D137 T138 G139 T141 K165 F186 V187 D193 K65 I122 D124 T125 G126 T128 K152 F173 V174 D180 E133 D134 D137 F186 R199 E120 D121 D124 F173 R186 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 -logKd/Ki=7.10, Ki=0.08uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKY 4rad D 2.0 BS01 3L5 D 1 I135 D137 T138 G139 T141 K165 F186 V187 D193 I120 D122 T123 G124 T126 K150 F171 V172 D178 E133 D134 D137 F186 R199 E118 D119 D122 F171 R184 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad E 2.0 BS01 3L5 E 1 D134 I135 D137 T138 G139 T141 K165 F186 V187 D193 R199 D126 I127 D129 T130 G131 T133 K157 F175 V176 D182 R188 E133 D134 D137 F186 R199 E125 D126 D129 F175 R188 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad F 2.0 BS01 3L5 F 1 K102 I135 D137 T138 G139 T141 K165 F186 V187 K99 I118 D120 T121 G122 T124 K148 F166 V167 E133 D134 D137 F186 R199 E116 D117 D120 F166 R179 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSIKVIGTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad G 2.0 BS01 3L5 G 1 I135 D137 T138 T141 K165 F186 V187 I121 D123 T124 T127 K151 F169 V170 E133 D134 D137 F186 R199 E119 D120 D123 F169 R182 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 PGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rad H 2.0 BS01 3L5 H 1 K68 D137 T138 G139 T141 K165 F186 V187 D193 R199 K66 D128 T129 G130 T132 K156 F177 V178 D184 R190 E133 D134 D137 F186 R199 E124 D125 D128 F177 R190 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 P00492 25494538 301 RSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 5knr A 2.864 BS01 3L5 A 1 G48 D104 I105 I106 D107 S108 G109 N110 T111 L112 K135 F156 V157 I162 G44 D95 I96 I97 D98 S99 G100 N101 T102 L103 K126 F147 V148 I153 E103 D104 D107 F156 R169 E94 D95 D98 F147 R160 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032991,0042802,0046100,0046872,0051289,0052657,0097216 -logKd/Ki=5.85, Ki=1.4uM P0A9M2 201 MKHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYGTRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDYAQRYRHLPYIGKVILLD 5knr B 2.864 BS01 3L5 B 1 G48 E103 I105 D107 S108 G109 T111 K135 F156 V157 I162 D163 R169 G43 E93 I95 D97 S98 G99 T101 K125 F146 V147 I152 D153 R159 E103 D104 D107 F156 R169 E93 D94 D97 F146 R159 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0032263,0032264,0032991,0042802,0046100,0046872,0051289,0052657,0097216 P0A9M2 201 KHTVEVMIPEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSSTTRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREVNVPVEFIGFSIPDEFVVGYGIDYAQRYRHLPYIGKVILL