4rac A 2.05 BS01 3L4 A 1 K68 G69 D137 T138 G139 T141 K165 F186 V187 D193 R199 K65 G66 D124 T125 G126 T128 K152 F173 V174 D180 R186 E133 D134 D137 F186 R199 E120 D121 D124 F173 R186 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=0.03uM -logKd/Ki=7.52, Ki=0.03uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rac B 2.05 BS01 3L4 B 1 K68 G69 I135 D137 T138 G139 K140 T141 K165 F186 V187 D193 R199 K65 G66 I119 D121 T122 G123 K124 T125 K149 F170 V171 D177 R183 E133 D134 D137 F186 R199 E117 D118 D121 F170 R183 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=0.03uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSSIPMTVDFIRLKSDIKVIDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYK 4rac C 2.05 BS01 3L4 C 1 K68 G69 I135 D137 T138 G139 T141 K165 F186 V187 D193 R199 K63 G64 I121 D123 T124 G125 T127 K151 F172 V173 D179 R185 E133 D134 D137 F186 R199 E119 D120 D123 F172 R185 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=0.03uM -logKd/Ki=7.52, Ki=0.03uM P00492 25494538 301 GVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 4rac D 2.05 BS01 3L4 D 1 I135 D137 T138 T141 K165 F186 V187 D193 I120 D122 T123 T126 K148 F167 V168 D174 E133 D134 D137 F186 R199 E118 D119 D122 F167 R180 2.4.2.8 0000166,0000287,0001913,0001975,0004422,0005515,0005737,0005829,0006164,0006166,0006178,0007625,0007626,0016757,0021756,0021895,0021954,0032263,0032264,0042417,0042802,0043103,0044209,0045964,0046038,0046040,0046083,0046100,0046651,0046872,0048813,0051289,0052657,0070062,0071542 Ki=0.03uM P00492 25494538 301 SPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRNPKMVKVASLLVKRRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA 6apv A 1.993 BS01 3L4 A 1 K54 G55 I115 D117 T118 A119 T121 K145 F166 V167 D173 R179 K50 G51 I90 D92 T93 A94 T96 K120 F141 V142 D148 R154 E113 D114 D117 F166 R179 E88 D89 D92 F141 R154 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Ki=0.11uM -logKd/Ki=6.96, Ki=0.11uM Q07010 29481567 301 CKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRADIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELE 6apv B 1.993 BS01 3L4 B 1 K54 G55 I115 D117 T118 A119 T121 K145 F166 V167 D173 R179 K50 G51 I93 D95 T96 A97 T99 K123 F144 V145 D151 R157 E113 D114 D117 F166 R179 E91 D92 D95 F144 R157 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Ki=0.11uM -logKd/Ki=6.96, Ki=0.11uM Q07010 29481567 301 CKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRASSYDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELERRKAA 6apv C 1.993 BS01 3L4 C 1 K54 G55 I115 D117 T118 A119 T121 K145 F166 V167 D173 R179 K50 G51 I90 D92 T93 A94 T96 K120 F141 V142 D148 R154 E113 D114 D117 F166 R179 E88 D89 D92 F141 R154 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Ki=0.11uM Q07010 29481567 301 CKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRADIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKEL 6apv D 1.993 BS01 3L4 D 1 K54 G55 I115 D117 T118 A119 T121 K145 F166 V167 D173 R179 K50 G51 I90 D92 T93 A94 T96 K120 F141 V142 D148 R154 E113 D114 D117 F166 R179 E88 D89 D92 F141 R154 2.4.2.8 0000166,0000287,0004422,0005737,0005829,0006166,0006178,0016757,0020015,0031981,0032263,0032264,0046100,0046872,0052657,0097014 Ki=0.11uM Q07010 29481567 301 CKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRADIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELER 6ar9 A 2.28 BS01 3L4 A 1 G88 D148 D151 T152 G153 T155 K180 Y201 V202 E208 R214 G81 D128 D131 T132 G133 T135 K160 Y181 V182 E188 R194 E147 D148 D151 Y201 R214 E127 D128 D131 Y181 R194 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM -logKd/Ki=5.18, Ki=6.54uM Q38CA1 29481567 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 B 2.28 BS01 3L4 B 1 G88 D148 A150 D151 T152 G153 T155 K180 Y201 V202 F207 E208 G81 D126 A128 D129 T130 G131 T133 K158 Y179 V180 F185 E186 E147 D148 D151 Y201 R214 E125 D126 D129 Y179 R192 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRILDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 C 2.28 BS01 3L4 C 1 G88 D148 D151 T152 G153 T155 K180 Y201 V202 F207 E208 G80 D123 D126 T127 G128 T130 K155 Y176 V177 F182 E183 E147 D148 D151 Y201 R214 E122 D123 D126 Y176 R189 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRINLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 D 2.28 BS01 3L4 D 1 I149 D151 T152 G153 T155 K180 Y201 V202 E208 I124 D126 T127 G128 T130 K155 Y176 V177 E183 E147 D148 D151 Y201 R214 E122 D123 D126 Y176 R189 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRINLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 E 2.28 BS01 3L4 E 1 I149 D151 T152 G153 T155 K180 Y201 V202 E208 I129 D131 T132 G133 T135 K160 Y181 V182 E188 E147 D148 D151 Y201 R214 E127 D128 D131 Y181 R194 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 PNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRITQVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL 6ar9 F 2.28 BS01 3L4 F 1 I149 D151 T152 G153 T155 K180 Y201 V202 E208 I128 D130 T131 G132 T134 K159 Y180 V181 E187 E147 D148 D151 Y201 R214 E126 D127 D130 Y180 R193 ? 0000166,0000287,0000310,0004422,0005737,0005829,0006178,0016757,0020015,0032263,0032264,0042301,0046100,0046872,0052657 Ki=6.54uM Q38CA1 29481567 301 KPNFVGRDADGNVTVDGRSYPMAESVVATESTIHRSMKEMAQTLANAYKTLKHRDTHNKGNSALAPITDENPLIIISVLKGSYIFTADMVRYLGDCGLPNVVDFIRIVLDNLRFTELTGKHVLIMEDIADTGRTMKLLVEKIRREYRPASLKVCVLVDKPGGRVVDFKPEFVCLTAPTRYVVGYGFEVNDRYRNYRHVFVLKPEYAKRYPSKL