4r6e A 2.2 BS01 3JD A 1 D766 H862 G863 Y889 Y896 F897 K903 S904 Y907 D106 H202 G203 Y229 Y236 F237 K243 S244 Y247 S904 Y907 E988 S244 Y247 E328 2.4.2.-,2.4.2.30 0003950 ic50=132nM -logKd/Ki=7.78, IC50=16.7nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4r6e B 2.2 BS01 3JD B 1 E763 D766 H862 G863 Y889 Y896 F897 K903 S904 Y907 E102 D105 H201 G202 Y228 Y235 F236 K242 S243 Y246 S904 Y907 E988 S243 Y246 E327 2.4.2.-,2.4.2.30 0003950 ic50=132nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKT 4r6e C 2.2 BS01 3JD C 1 D766 H862 G863 Y889 Y896 F897 S904 Y907 D106 H202 G203 Y229 Y236 F237 S244 Y247 S904 Y907 E988 S244 Y247 E328 2.4.2.-,2.4.2.30 0003950 ic50=132nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 MKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 4r6e D 2.2 BS01 3JD D 1 D766 H862 G863 G888 Y889 Y896 F897 A898 S904 Y907 D104 H200 G201 G226 Y227 Y234 F235 A236 S242 Y245 S904 Y907 E988 S242 Y245 E326 2.4.2.-,2.4.2.30 0003950 ic50=132nM IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 28001384 1101 SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKAEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7f43 B 1.62 BS01 3JD B 1 H559 G560 C578 G580 N582 A583 V584 Y591 Y598 S599 Y604 H81 G82 C100 G102 N104 A105 V106 Y113 Y120 S121 Y126 2.4.2.- 0003950 Q460N3 701 HHNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA 7kk5 A 1.7 BS01 3JD A 1 Q759 D766 H862 G863 Y889 Y896 F897 S904 Y907 Q93 D100 H191 G192 Y218 Y225 F226 S233 Y236 S904 Y907 E988 S233 Y236 E317 2.4.2.-,2.4.2.30 0003950 IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 33361107 9001 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQDSQILDLSNRFYTLIPHDFGKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7kk5 B 1.7 BS01 3JD B 1 Q759 V762 D766 H862 G863 Y889 Y896 F897 K903 S904 Y907 E988 Q96 V99 D103 H195 G196 Y222 Y229 F230 K236 S237 Y240 E321 S904 Y907 E988 S237 Y240 E321 2.4.2.-,2.4.2.30 0003950 IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 33361107 9001 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7kk5 C 1.7 BS01 3JD C 1 Q759 V762 E763 D766 H862 G863 Y889 Y896 F897 K903 S904 Y907 Q93 V96 E97 D100 H196 G197 Y223 Y230 F231 K237 S238 Y241 S904 Y907 E988 S238 Y241 E322 2.4.2.-,2.4.2.30 0003950 IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 33361107 9001 SKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7kk5 D 1.7 BS01 3JD D 1 D766 H862 G863 Y889 Y896 F897 S904 Y907 D94 H184 G185 Y211 Y218 F219 S226 Y229 S904 Y907 E988 S226 Y229 E310 2.4.2.-,2.4.2.30 0003950 IC50=132nM, Ki=3.2nM, EC50=31000nM P09874 33361107 1103 KSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQILDLSNRFYTLIPHDPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFK 7kkp A 1.4 BS02 3JD A 1 H1184 G1185 Y1213 S1221 Y1224 I1228 E1291 H80 G81 Y109 S117 Y120 I124 E181 2.4.2.-,2.4.2.30 0003950 IC50=2355nM O95271 33361107 1402 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPYAEYVIYRGEQAYPEYLITYQIMKPE 7kkp B 1.4 BS02 3JD B 1 H1184 G1185 Y1203 G1205 Y1213 S1221 Y1224 I1228 E1291 H80 G81 Y99 G101 Y109 S117 Y120 I124 E185 2.4.2.-,2.4.2.30 0003950 IC50=2355nM O95271 33361107 1402 GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNAYAEYVIYRGEQAYPEYLITYQIMKPE 8hlq A 2.7 BS01 3JD A 1 S328 I331 E335 H428 G429 G454 Y455 Y462 F463 A464 S470 Y473 E558 S100 I103 E107 H200 G201 G226 Y227 Y234 F235 A236 S242 Y245 E330 2.4.2.-,2.4.2.30 0003950 Q9UGN5 602 GPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKSERQGLEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQ 8hlq B 2.7 BS01 3JD B 1 S328 I331 E335 H428 G429 G454 Y455 Y462 F463 A464 S470 Y473 E558 S100 I103 E107 H200 G201 G226 Y227 Y234 F235 A236 S242 Y245 E330 2.4.2.-,2.4.2.30 0003950 Q9UGN5 603 GPESQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKSERQGLEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQ 8i2m A 2.1 BS01 3JD A 1 F7 G9 Q11 H45 L125 Y128 M132 D135 Q150 F5 G7 Q9 H42 L113 Y116 M120 D123 Q138 6.1.1.2 0000166,0004812,0004830,0005524,0005737,0005829,0006412,0006418,0006436 P00954 37070195 401 KPIVFSGAQPSELTIGNYMGALRQWVNMQDDYHCIYCIVDQHAITVRQDAQKLRKATLDTLALYLACGIDPEKSTIFVQSHVPEHAQLGWALNCYTYFGELSRMTAENINAGLFDYPVLMAADILLYQTNLVPVGEDQKQHLELSRDIAQRFNALYGEIFKVPEPFIPKSGARVMSLLEPTKKMSKSDDNRNNVIGLLEDPKSVVKKIKRAVTDSDEPPVVRYDVQNKAGVSNLLDILSAVTGQSIPELEKQFEGKMYGHLKGEVADAVSGMLTELQERYHRFRNDEAFLQQVMKDGAEKASAHASRTLKAVYEAIGFVAKRH 8tnc A 1.4 BS01 3JD A 1 I21 T28 D29 E32 Q54 V57 V94 V124 G127 A130 D131 I21 T28 D29 E32 Q54 V57 V94 V124 G127 A130 D131 38574125 201 SDAQEILSRLNSVLEAAWKTILNLASATDAAEKAYKEGREEDLATYLDQAASYQSQVDQYAVETVRLLAELKKVFPDEEADRALQIAEKLLKTVQEASKTLDTAVAAAANGDEETFAKAFNQFVSLGNQADTLFTQLQRTLTNLNKK 8tnc B 1.4 BS01 3JD B 1 I21 T28 D29 Q54 V94 G127 N128 A130 D131 I21 T28 D29 Q54 V94 G127 N128 A130 D131 38574125 201 SDAQEILSRLNSVLEAAWKTILNLASATDAAEKAYKEGREEDLATYLDQAASYQSQVDQYAVETVRLLAELKKVFPDEEADRALQIAEKLLKTVQEASKTLDTAVAAAANGDEETFAKAFNQFVSLGNQADTLFTQLQRTLTNLNKK 8tnc C 1.4 BS01 3JD C 1 I21 L24 T28 D29 Q54 V94 G127 A130 D131 I21 L24 T28 D29 Q54 V94 G127 A130 D131 38574125 201 SDAQEILSRLNSVLEAAWKTILNLASATDAAEKAYKEGREEDLATYLDQAASYQSQVDQYAVETVRLLAELKKVFPDEEADRALQIAEKLLKTVQEASKTLDTAVAAAANGDEETFAKAFNQFVSLGNQADTLFTQLQRTLTNLNKK