4w7p A 2.8 BS01 3J7 A 1 I82 V90 A103 K105 E154 Y155 M156 D160 D202 D216 I77 V85 A98 K100 E146 Y147 M148 D152 D194 D208 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.49, IC50=32nM IC50=32nM Q13464 25248678 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEETFPIPKAFVGNQLPFVGFTYYSNRRY 4w7p B 2.8 BS01 3J7 B 1 I82 V90 A103 K105 M156 D160 L205 D216 F368 I77 V85 A98 K100 M148 D152 L197 D208 F357 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=32nM Q13464 25248678 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEEEETFPIPKAFVGNQLPFVGFTYYS 4w7p C 2.8 BS01 3J7 C 1 I82 V90 A103 K105 E154 Y155 M156 D160 L205 D216 F368 I77 V85 A98 K100 E146 Y147 M148 D152 L197 D208 F356 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=32nM Q13464 25248678 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEETFPIPKAFVGNQLPFVGFTYYS 4w7p D 2.8 BS01 3J7 D 1 I82 V90 A103 K105 E154 Y155 M156 D160 D202 L205 D216 I77 V85 A98 K100 E146 Y147 M148 D152 D194 L197 D208 D198 K200 N203 D216 T237 D190 K192 N195 D208 T229 2.7.11.1 0004672,0004674,0005524,0006468 IC50=32nM Q13464 25248678 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEETFPIPKAFVGNQLPFVGFTYYSNR