4d2t A 2.7 BS01 3I7 A 1 A38 K40 E57 C70 E87 Y88 C89 P90 I149 A38 K40 E54 C67 E84 Y85 C86 P87 I146 D132 K134 E136 N137 D150 A171 D129 K131 E133 N134 D147 A156 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=6.00, IC50=1.0uM Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCACCGALAYAAPELIQGKSGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2t B 2.7 BS01 3I7 B 1 I17 L27 E87 C89 P90 I149 I18 L27 E87 C89 P90 I149 D132 K134 E136 N137 D150 A171 D132 K134 E136 N137 D150 A165 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 HMKDYDELLKYYELHETIGTGGAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDCGALAYAAPELIQGGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2t C 2.7 BS01 3I7 C 1 I17 K40 Y88 C89 P90 I149 I17 K40 Y84 C85 P86 I145 D132 K134 E136 N137 D150 A171 D128 K130 E132 N133 D146 A154 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKGALAYAAPELIQGKGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR 4d2t D 2.7 BS01 3I7 D 1 I17 L27 E87 Y88 C89 P90 G92 L139 I149 I15 L25 E85 Y86 C87 P88 G90 L137 I147 D132 K134 E136 N137 D150 A171 D130 K132 E134 N135 D148 A161 2.7.10.2,2.7.11.1 0004672,0004674,0005524,0006468 Q14680 25589925 1334 DYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKGALAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDTAAALVAKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLR