1u1w A 1.35 BS01 3HA A 1 E45 A72 G73 H74 M198 Y203 D208 T211 G212 S213 E45 A72 G73 H74 M198 Y203 D208 T211 G212 S213 5.3.3.17 0002047,0003824,0005737,0009058,0016853,0017000,0102943 Kd=1.4uM -logKd/Ki=5.85, Kd=1.4uM Q51792 15545603 700 MHNYVIIDAFASVPLEGNPVAVFFDADDLPPAQMQRIAREMNLSESTFVLKPRNGGDALIRIFTPVNELPFAGHPLLGTAIALGAHTDNHRLYLETQMGTIAFELERQNGSVIAASMDQPIPTWTALGRDAELLKALGISDSTFPIEIYHNGPRHVFVGLPSIDALSALHPDHRALSNFHDMAINCFAGAGRRWRSRMFSPAYGVVEDAATGSAAGPLAIHLARHGQIEFGQPVEILQGVEIGRPSLMFAKAEGRAEQLTRVEVSGNGVTFGRGTIVL 1u1w B 1.35 BS01 3HA B 1 E45 A72 G73 H74 M198 Y203 D208 T211 G212 S213 E46 A73 G74 H75 M199 Y204 D209 T212 G213 S214 5.3.3.17 0002047,0003824,0005737,0009058,0016853,0017000,0102943 Kd=1.4uM Q51792 15545603 701 HMHNYVIIDAFASVPLEGNPVAVFFDADDLPPAQMQRIAREMNLSESTFVLKPRNGGDALIRIFTPVNELPFAGHPLLGTAIALGAHTDNHRLYLETQMGTIAFELERQNGSVIAASMDQPIPTWTALGRDAELLKALGISDSTFPIEIYHNGPRHVFVGLPSIDALSALHPDHRALSNFHDMAINCFAGAGRRWRSRMFSPAYGVVEDAATGSAAGPLAIHLARHGQIEFGQPVEILQGVEIGRPSLMFAKAEGRAEQLTRVEVSGNGVTFGRGTIVL 1yfy A 3.2 BS03 3HA A 1 N27 H51 E57 H95 P97 E110 N27 H51 E57 H95 P97 E110 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 15909978 401 MLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDGFEWYCDACGHLVHRVEVQLKSIVTDLPPLFESFYASEDKRRCPHCGQVHPGRAA 4hsl A 2.0 BS03 3HA A 1 V25 V41 R47 H51 E57 F59 P97 R99 V25 V41 R47 H51 E57 F59 P97 R99 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 203 MLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIARQRPAGMLDGFEWYCDACGHLVHRVEVQLKSIVTDLPPLFESFYASEDKRRCPHCGQVHPGRAA 6cd3 A 2.612 BS03 3HA A 1 V41 P97 R99 V108 E110 V40 P96 R98 V107 E109 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 29784877 203 LTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDGFEWYCDACGHLVHRVEVQLKSAVTDLPPLFESFYASEDKRRCPHCGQVHPG 6d62 A 1.77 BS03 3HA A 1 V41 F59 P97 R99 V108 E110 V41 F59 P97 R99 V108 E110 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 29784877 203 MLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDGFEWYCDACGHLVHRVEVQLKSPVTDLPPLFESFYASEDKRRCPHCGQVHPGRAA 6siy A 1.95 BS01 3HA A 1 L138 A212 E235 G237 S238 L135 A209 E232 G234 S235 ? 0000166,0016874,0046872 A0A022MRT4 31903677 501 SRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRTADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYTEEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATVVPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQDFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPEGRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADDVEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAYEVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLAPGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF 6siy A 1.95 BS03 3HA A 2 T128 P129 T135 R156 N180 T125 P126 T132 R153 N177 ? 0000166,0016874,0046872 A0A022MRT4 31903677 508 SRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRTADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYTEEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATVVPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQDFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPEGRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADDVEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAYEVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLAPGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF 6siy B 1.95 BS04 3HA B 1 L138 A211 E235 G237 S238 T239 L138 A211 E235 G237 S238 T239 ? 0000166,0016874,0046872 A0A022MRT4 31903677 502 MSRSRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRTADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYTEEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATVVPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQDFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPEGRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADDVEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAYEVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLAPGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF 6siy B 1.95 BS06 3HA B 2 T128 P129 T135 R156 N180 T128 P129 T135 R156 N180 ? 0000166,0016874,0046872 A0A022MRT4 31903677 507 MSRSRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRTADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYTEEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATVVPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQDFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPEGRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADDVEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAYEVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLAPGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF 6siz A 1.77 BS02 3HA A 1 L138 A211 E235 G237 L135 A208 E232 G234 ? 0000166,0016874,0046872 A0A022MRT4 31903677 502 SRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRTADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYTEEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATVVPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQDFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPEGRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADDVEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAYEVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLAPGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF 6siz B 1.77 BS03 3HA B 1 L138 A211 E235 G237 S238 L139 A212 E236 G238 S239 ? 0000166,0016874,0046872 A0A022MRT4 31903677 502 AMSRSRPELGDWSSPAELAELQRSQLPRVLAQALRSPFYAARYRGTTPPRTADDFAGVEVTAKQDLRDQYPFGMLAVGREHLATYHESSGTAGEPTASYYTEEDWTDLAERFARKWTGIHPSDTFLVRTPYGLVITGHLAQAAGRLRGATVVPGDARSLATPLSRMVRVLKTLDVTLTWCNPTEITMLAAAAKAAGLRPDQDFPHLRAMFTAAEPLTEVRRRRLSEIWGGIPVVEEYGSTETGTIAGQCPEGRMHLWADRAIFEVYDPRTGTLSEAGRGQMVVTPLYRDAMPLLRYNLADDVEVSTDPCGCGWLLPTVTVLGRAGTGHRIGPATVTQQRLEELVFSLPAAYEVMFWRAKAHPDVLELEFEAPEPVRQRAVKELGAALDRELGVPHRITGLAPGTLVPAEALTAQRDILKARYLFAEDEDWDKAVMYF 6sj2 A 1.25 BS01 3HA A 1 H77 M103 F116 Y227 H253 A256 L257 H290 E321 D345 H78 M104 F117 Y228 H254 A257 L258 H291 E322 D346 ? 0016787,0016810,0046872 A0A022MQ12 31903677 501 AMGARLITGGTVYTADAQESVHARGAVLTVDDKVVAVGPAVEVEQAVQALDPAVRAELRRLDASRMMVLPGFVNAHWHEMFAMGFTMRGALRPPSDRADQVAFMGGGGDMHQISATFDRFDGLIEAMTEDEARAIAEYSMWIQLRGGVTTLGDMGSLNRPLAMVEAARRLGMRFSASTWASDAVLAPDRSRFLRTRDADTVLASFEALLGAVAADPTGRIRCRPNVSYVTNMTDELARGMAELVERHDLPFATHVGALRNEADAMRAYHGETGVRRLAEAGLVDERLMAGHSAFLDDQEQKLMLAGRAHISHSPGKYGPSGESALTETGVVPALRRAGLDVSLSTDAAALPGAGIAETMRAAWQMYNEMSADQTEVLPTDALAMATRIAAKGLRWDDAVGSLEPGKQADLLLVRTDDWRYLLNPRPLESFLWLAGSADVDTVIVGGRTLVEGGRGVEVDEAALRDRYLQALRGFTTRALRVPAEAVDPVLAEVAR 6sj2 B 1.25 BS01 3HA B 1 H77 M103 F116 Y227 H253 A256 L257 H290 E321 D345 H86 M112 F125 Y236 H262 A265 L266 H299 E330 D354 ? 0016787,0016810,0046872 A0A022MQ12 31903677 501 TENLYFQGAMGARLITGGTVYTADAQESVHARGAVLTVDDKVVAVGPAVEVEQAVQALDPAVRAELRRLDASRMMVLPGFVNAHWHEMFAMGFTMRGALRPPSDRADQVAFMGGGGDMHQISATFDRFDGLIEAMTEDEARAIAEYSMWIQLRGGVTTLGDMGSLNRPLAMVEAARRLGMRFSASTWASDAVLAPDRSRFLRTRDADTVLASFEALLGAVAADPTGRIRCRPNVSYVTNMTDELARGMAELVERHDLPFATHVGALRNEADAMRAYHGETGVRRLAEAGLVDERLMAGHSAFLDDQEQKLMLAGRAHISHSPGKYGPSGESALTETGVVPALRRAGLDVSLSTDAAALPGAGIAETMRAAWQMYNEMSADQTEVLPTDALAMATRIAAKGLRWDDAVGSLEPGKQADLLLVRTDDWRYLLNPRPLESFLWLAGSADVDTVIVGGRTLVEGGRGVEVDEAALRDRYLQALRGFTTRALRVPAEAVDPVLAEVAR 6vi6 A 1.901 BS03 3HA A 1 H51 E57 F59 P97 R99 E110 I142 H51 E57 F59 P97 R99 E110 I142 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 32732435 204 MLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDGFEWYCDACGHLVHRVEVQLKSIVTDLPPLFESFYASEDKRRCPHCGQVHPGRAA 6vi7 A 2.617 BS01 3HA A 1 H51 E57 P97 R99 E110 I142 H52 E58 P98 R100 E111 I143 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 32732435 201 HMLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDGFEWYCDACGHLVHRVEVQLKSIVTDLPPLFESFYASEDKRRCPHCGQVHPGR 6vi8 A 1.95 BS04 3HA A 1 H51 E57 F59 P97 R99 E110 H53 E59 F61 P99 R101 E112 1.13.11.6 0000334,0005506,0006569,0008198,0009435,0019363,0019805,0034354,0043420,0046872,0051213 Q1LCS4 32732435 206 RHMLTYGAPFNFPRWIDEHAHLLKPPVGNRQVWQDSDFIVTVVGGPNHRTDYHDDPLEEFFYQLRGNAYLNLWVDGRRERADLKEGDIFLLPPHVRHSPQRPEAGSACLVIERQRPAGMLDGFEWYCDACGHLVHRVEVQLKSIVTDLPPLFESFYASEDKRRCPHCGQVHPGRAA