4ua7 A 0.89 BS01 3GK A 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 D240 N79 Y80 S105 N107 P142 N145 T146 T210 G211 S212 G213 D214 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 301 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ua7 A 0.89 BS02 3GK A 2 N104 Y105 S237 S274 N79 Y80 S212 S247 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 302 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ua7 B 0.89 BS01 3GK B 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 D240 N76 Y77 S102 N104 P139 N142 T143 T207 G208 S209 G210 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 301 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4ua7 B 0.89 BS02 3GK B 2 N104 Y105 S237 S274 N76 Y77 S209 S244 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 302 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4uaa A 0.86 BS01 3GK A 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 D240 N79 Y80 S105 N107 P142 N145 T146 T210 G211 S212 G213 D214 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 301 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4uaa A 0.86 BS02 3GK A 2 N104 Y105 S237 S274 N79 Y80 S212 S247 S70 K73 S130 E166 K234 S237 S45 K48 S105 E141 K209 S212 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 302 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4uaa B 0.86 BS01 3GK B 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 D240 N76 Y77 S102 N104 P139 N142 T143 T207 G208 S209 G210 D211 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 301 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 4uaa B 0.86 BS02 3GK B 2 N104 Y105 S237 S274 N76 Y77 S209 S244 S70 K73 S130 E166 K234 S237 S42 K45 S102 E138 K206 S209 3.5.2.6 0008800,0016787,0017001,0030655,0046677 H6UQI0 26057252 302 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bt6 A 1.05 BS01 3GK A 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 A237 G238 D240 N79 Y80 S105 N107 P142 N145 T146 T210 G211 A212 G213 D214 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Ki=1.23uM -logKd/Ki=5.91, Ki=1.23uM Q9L5C7 29844038 301 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGAGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bt6 A 1.05 BS02 3GK A 2 N104 Y105 A237 N79 Y80 A212 S70 K73 S130 E166 K234 A237 S45 K48 S105 E141 K209 A212 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Ki=1.23uM -logKd/Ki=5.91, Ki=1.23uM Q9L5C7 29844038 302 PTSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGAGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bt6 B 1.05 BS01 3GK B 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 A237 G238 D240 N76 Y77 S102 N104 P139 N142 T143 T207 G208 A209 G210 D211 S70 K73 S130 E166 K234 A237 S42 K45 S102 E138 K206 A209 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Ki=1.23uM Q9L5C7 29844038 301 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGAGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bt6 B 1.05 BS02 3GK B 2 N104 Y105 A237 N76 Y77 A209 S70 K73 S130 E166 K234 A237 S42 K45 S102 E138 K206 A209 3.5.2.6 0008800,0016787,0017001,0030655,0046677,0046872 Ki=1.23uM Q9L5C7 29844038 302 AVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKPADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGAGDYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bu3 A 1.15 BS01 3GK A 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 N78 Y79 S104 N106 P141 N144 T145 T209 G210 S211 G212 S70 K73 S130 E166 K234 S237 S44 K47 S104 E140 K208 S211 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=0.28uM -logKd/Ki=6.55, Ki=0.28uM B5LY47 29844038 301 TSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKHADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bu3 A 1.15 BS02 3GK A 2 N104 Y105 S237 N78 Y79 S211 S70 K73 S130 E166 K234 S237 S44 K47 S104 E140 K208 S211 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=0.28uM -logKd/Ki=6.55, Ki=0.28uM B5LY47 29844038 302 TSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKHADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bu3 B 1.15 BS01 3GK B 1 N104 Y105 S130 N132 P167 N170 T171 T235 G236 S237 G238 G240 N78 Y79 S104 N106 P141 N144 T145 T209 G210 S211 G212 G213 S70 K73 S130 E166 K234 S237 S44 K47 S104 E140 K208 S211 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=0.28uM B5LY47 29844038 301 TSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKHADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL 6bu3 B 1.15 BS02 3GK B 2 N104 Y105 S237 S274 N78 Y79 S211 S246 S70 K73 S130 E166 K234 S237 S44 K47 S104 E140 K208 S211 3.5.2.6 0008800,0016787,0017001,0030655,0046677 Ki=0.28uM B5LY47 29844038 302 TSAVQQKLAALEKSSGGRLGVALIDTADNTQVLYRGDERFPMCSTSKVMAAAAVLKQSETQKQLLNQPVEIKHADLVNYNPIAEKHVNGTMTLAELSAAALQYSDNTAMNKLIAQLGGPGGVTAFARAIGDETFRLDRTEPTLNTAIPGDPRDTTTPRAMAQTLRQLTLGHALGETQRAQLVTWLKGNTTGAASIRAGLPTSWTVGDKTGSGGYGTTNDIAVIWPQGRAPLVLVTYFTQPQQNAESRRDVLASAARIIAEGL