4ca5 A 1.85 BS03 3EF A 1 Q281 H353 A354 S355 A356 E376 V380 H383 E384 H387 F391 H410 F457 K511 F512 H513 V518 Y520 Y523 F527 Q242 H314 A315 S316 A317 E337 V341 H344 E345 H348 F352 H371 F418 K472 F473 H474 V479 Y481 Y484 F488 H353 A354 H383 E384 H387 E411 H513 Y523 H314 A315 H344 E345 H348 E372 H474 Y484 3.4.15.1 0006508,0008237,0008241,0016020 Ki=0.41nM -logKd/Ki=9.39, Ki=0.41nM Ki=0.41nM P12821 24289879 1700 DEAEASKFVEEYDRTSQVVWNEYAEANWNYNTNITTETSKILLQKNMQIANHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKILLDMETTYSVATVCHPNGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKAGRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQELQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDLVVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQYFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSEGGSDEHDINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKYQGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAGHTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPNMSASAMLSYFKPLLDWLRTENELHGEKLGWPQYNWTPNS 4ca6 A 1.91 BS02 3EF A 1 Q259 H331 A332 S333 S357 T358 H361 E362 H365 Y369 H388 E389 D393 E431 F435 K489 F490 H491 T496 Y498 Y501 F505 Q257 H329 A330 S331 S355 T356 H359 E360 H363 Y367 H386 E387 D391 E429 F433 K487 F488 H489 T494 Y496 Y499 F503 H331 A332 H361 E362 H365 E389 H491 Y501 H329 A330 H359 E360 H363 E387 H489 Y499 3.4.15.1 0006508,0008237,0008241,0016020 Ki=180nM -logKd/Ki=6.74, Ki=180nM Ki=0.41nM P12821 24289879 1630 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLKTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEG 4ca6 B 1.91 BS02 3EF B 1 Q259 H331 A332 S333 S357 T358 H361 E362 H365 Y369 H388 E389 D393 F435 K489 F490 H491 T496 Y498 Y501 F505 Q257 H329 A330 S331 S355 T356 H359 E360 H363 Y367 H386 E387 D391 F433 K487 F488 H489 T494 Y496 Y499 F503 H331 A332 H361 E362 H365 E389 H491 Y501 H329 A330 H359 E360 H363 E387 H489 Y499 3.4.15.1 0006508,0008237,0008241,0016020 Ki=180nM Ki=0.41nM P12821 24289879 1630 LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAENARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGSANLPLAKRQQYNALLSQMSRIYSTAKVCLPTATCWSLDPDLTNILASSRSYAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPDNYPEG 4ca7 A 1.82 BS02 3EF A 1 Q265 Q266 H337 A338 S339 A340 D360 F363 T364 H367 E368 H371 F375 H394 D399 K495 H497 V502 Y504 Y507 F511 Q247 Q248 H319 A320 S321 A322 D342 F345 T346 H349 E350 H353 F357 H376 D381 K477 H479 V484 Y486 Y489 F493 H337 A338 H367 E368 H371 E395 H497 Y507 H319 A320 H349 E350 H353 E377 H479 Y489 3.4.15.1 0006508,0008237,0008241,0016020 Ki=24nM -logKd/Ki=7.36, Ki=44nM Q10714 24289879 1715 VKEEIQAKEYLENLNKELAKRTNVETEAAWAYGSNITDENEKKKNEISAELAKFMKEVASDTTKFQWRSYQSEDLKRQFKALTKLGYAALPEDDYAELLDTLSAMESNFAKVKVCDYKDSTKCDLALDPEIEEVISKSRDHEELAYYWREFYDKAGTAVRSQFERYVELNTKAAKLNNFTSGAEAWLDEYEDDTFEQQLEDIFADIRPLYQQIHGYVRFRLRKHYGDAVVSETGPIPMHLLGNMWAQQWSEIADIVSPFPEKPLVDVSAEMEKQGYTPLKMFQMGDDFFTSMNLTKLPQDFWDKSIIEKPTDGRDLVCHASAWDFYLTDDVRIKQCTRVTQDQLFTVHHELGHIQYFLQYQHQPFVYRTGANPGFHEAVGDVLSLSVSTPKHLEKIGLLKDYVRDDEARINQLFLTALDKIVFLPFAFTMDKYRWSLFRGEVDKANWNCAFWKLRDEYSGIEPPVVRSEKDFDAPAKYHISADVEYLRYLVSFIIQFQFYKSACIKAGQYDPDNVELPLDNCDIYGSAAAGAAFHNMLSMGASKPWPDALEAFNGERIMSGKAIAEYFEPLRVWLEAENIKNNVHIGWTTSNKCVS