4nq5 A 2.29 BS03 3C7 A 1 W59 H88 D90 H149 G179 N180 H210 W47 H76 D78 H137 G167 N168 H198 H86 H88 D90 H149 C168 K171 N180 H210 H74 H76 D78 H137 C156 K159 N168 H198 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P04190 303 TVIKNETGTISISQLNKNVWVHTELAVPSNGLVLNTSKGLVLVDSSWDDKLTKELIEMVEKKFQKRVTDVIITHAHADRIGGIKTLKERGIKAHSTALTAELAKKNGYEEPLGDLQTVTNLKFGNMKVETFYPGKGHTEDNIVVWLPQYNILVGGCLVKSTSAKDLGNVADAYVNEWSTSIENVLKRYRNINAVVPGHGEVGDKGLLLHTLDLLK 4u4l A 1.9 BS03 3C7 A 1 W93 H122 D124 H189 H250 W52 H81 D83 H148 H209 H120 H122 D124 H189 C208 K211 N220 H250 H79 H81 D83 H148 C167 K170 N179 H209 3.5.2.6 C7C422 303 METGDQRFGDLVFRQLAPNVWQHTSYLDMGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4u4l B 1.9 BS03 3C7 B 1 H122 D124 H189 H250 H83 D85 H150 H211 H120 H122 D124 H189 C208 K211 N220 H250 H81 H83 D85 H150 C169 K172 N181 H211 3.5.2.6 C7C422 303 ETGDQRFGDLVFRQLAPNVWQHTSYLDMPGFGAVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4u4l C 1.9 BS03 3C7 C 1 W93 H122 H189 H250 W46 H75 H142 H203 H120 H122 D124 H189 C208 K211 N220 H250 H73 H75 D77 H142 C161 K164 N173 H203 3.5.2.6 C7C422 304 DQRFGDLVFRQLAPNVWQHTSYLDMVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4u4l D 1.9 BS03 3C7 D 1 W93 H122 D124 H189 N220 H250 W47 H76 D78 H143 N174 H204 H120 H122 D124 H189 C208 K211 N220 H250 H74 H76 D78 H143 C162 K165 N174 H204 3.5.2.6 C7C422 304 TGDQRFGDLVFRQLAPNVWQHTSYLDVASNGLIVRDGGRVLVVDTAWTDDQTAQILNWIKQEINLPVALAVVTHAHQDKMGGMDALHAAGIATYANALSNQLAPQEGMVAAQHSLTFAANGWVEPATAPNFGPLKVFYPGPGHTSDNITVGIDGTDIAFGGCLIKDSKAKSLGNLGDADTEHYAASARAFGAAFPKASMIVMSHSAPDSRAAITHTARMADKLR 4ua4 A 1.25 BS03 3C7 A 1 Y65 H177 R203 N208 H238 Y38 H150 R176 N181 H211 H112 H114 D116 H177 C196 Y199 N208 H238 H85 H87 D89 H150 C169 Y172 N181 H211 3.5.2.6 0016787,0017001,0046872 Q9K2N0 304 SGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAH 4ua4 A 1.25 BS04 3C7 A 2 H114 D115 D116 E144 N146 N208 H87 D88 D89 E117 N119 N181 H112 H114 D116 H177 C196 Y199 N208 H238 H85 H87 D89 H150 C169 Y172 N181 H211 3.5.2.6 0016787,0017001,0046872 Q9K2N0 305 SGEYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAH 4ua4 B 1.25 BS01 3C7 B 1 F60 Y65 W85 D116 H177 R203 H238 F31 Y36 W56 D87 H148 R174 H209 H112 H114 D116 H177 C196 Y199 N208 H238 H83 H85 D87 H148 C167 Y170 N179 H209 3.5.2.6 0016787,0017001,0046872 Q9K2N0 301 EYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELLLIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGVATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHSTDNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYPEAQFVIPGHGLPGGLDLLKHTTNVVKAHTNRSVV 5evk A 1.627 BS01 3C7 A 1 W39 D120 H196 S225 W16 D87 H159 S186 H116 H118 D120 H121 H196 Y229 H263 H83 H85 D87 H88 H159 Y190 H224 3.5.2.6 0008270,0008800,0016787,0017001,0030655,0042597,0046677,0046872 Ki=12uM -logKd/Ki=4.92, Ki=12uM P52700 27303030 401 EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVLLDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTGAKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIVFTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPHLIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYADAAEQKFDGQLAKETAG 5ew0 A 1.3 BS02 3C7 A 1 H109 D111 F146 T147 H186 N213 H247 H69 D71 F106 T107 H146 N173 H207 N107 H109 D111 H186 C205 K208 N213 H247 N67 H69 D71 H146 C165 K168 N173 H207 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki=0.26uM -logKd/Ki=6.59, Ki=0.26uM Q9RMI1 27303030 302 NLTLTHFKGPLYIVEDKEYVQENSMVYIGTDGITIIGATWTPETAETLYKEIRKVSPLPINEVINTNYHTDRAGGNAYWKTLGAKIVATQMTYDLQKSQWGSIVNFTRQGNNKYPNLEKSLPDTVFPGDFNLQNGSIRAMYLGEAHTKDGIFVYFPAERVLYGNCILKENLGNMSFANRTEYPKTLEKLKGLIEQGELKVDSIIAGHDTPIHDVGLIDHYLTLLEKAP 5ew0 B 1.3 BS02 3C7 B 1 W80 H109 D111 F146 T147 H186 C205 N213 H247 W40 H69 D71 F106 T107 H146 C165 N173 H207 N107 H109 D111 H186 C205 K208 N213 H247 N67 H69 D71 H146 C165 K168 N173 H207 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki=0.26uM Q9RMI1 27303030 302 NLTLTHFKGPLYIVEDKEYVQENSMVYIGTDGITIIGATWTPETAETLYKEIRKVSPLPINEVINTNYHTDRAGGNAYWKTLGAKIVATQMTYDLQKSQWGSIVNFTRQGNNKYPNLEKSLPDTVFPGDFNLQNGSIRAMYLGEAHTKDGIFVYFPAERVLYGNCILKENLGNMSFANRTEYPKTLEKLKGLIEQGELKVDSIIAGHDTPIHDVGLIDHYLTLLEKAP