3agn A 0.96 BS01 3AM A 1 Y39 H41 Y44 E46 E49 E62 R85 H101 D108 F110 Y39 H41 Y44 E46 E49 E62 R85 H101 D108 F110 Y39 H41 E62 R85 H101 F110 Y39 H41 E62 R85 H101 F110 4.6.1.20 0003723,0004519,0004521,0004540,0016829,0033899,0046872 P00654 20606265 115 CDIPQSTNCGGNVYSNDDINTAIQGALDDVANGDRPDNYPHQYYDEASEDITLCCGSGPWSEFPLVYNGPYYSSRDNYVSPGPDRVIYQTNTGEFCATVTHTGAASYDGFTQCS 3ago A 0.99 BS01 3AM A 1 Y39 H41 Y44 E46 E49 E62 R85 H101 D108 F110 Y39 H41 Y44 E46 E49 E62 R85 H101 D108 F110 Y39 H41 E62 R85 H101 F110 Y39 H41 E62 R85 H101 F110 4.6.1.20 0003723,0004519,0004521,0004540,0016829,0033899,0046872 P00654 20606265 115 CDIPQSTNCGGNVYSNDDINTAIQGALDDVANGDRPDNYPHQYYDEASEDITLCCGSGPWSEFPLVYNGPYYSSRDNYVSPGPDRVIYQTNTGEFCATVTHTGAASYDGFTQCS 3c0g A 2.19 BS01 3AM A 1 V26 A39 K41 F91 M94 L148 G162 V21 A34 K36 F86 M89 L143 G157 D141 K143 H145 C146 G162 T182 D136 K138 H140 C141 G157 T177 2.7.11.1 0004672,0005524,0006468 O14936 18423203 338 VLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKVLAAVSFYG 3c0g B 2.19 BS01 3AM B 1 I18 V26 A39 K41 F91 M94 L148 I14 V22 A35 K37 F87 M90 L144 D141 K143 H145 C146 G162 T182 D137 K139 H141 C142 G158 T178 2.7.11.1 0004672,0005524,0006468 O14936 18423203 338 DVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDP 3c0i A 1.85 BS01 3AM A 1 V26 A39 K41 F91 M94 L148 G162 V21 A34 K36 F86 M89 L143 G157 D141 K143 H145 C146 G162 T182 D136 K138 H140 C141 G157 T177 2.7.11.1 0004672,0005524,0006468 O14936 18423203 338 VLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRK 3it3 A 1.5 BS01 3AM A 1 R16 H17 R20 F23 R84 Y135 H260 A261 R11 H12 R15 F18 R79 Y130 H255 A256 19836403 343 SKLIFVSMITRHGDRAPFANIENANYSWGTELSELTPIGMNQEYNLGLQLRKRYIDKFGLLPEHYVDQSIYVLSSHTNRTVVSAQSLLMGLYPAGTGPLIGDGDPAIKDRFQPIPIMTLSADSRLIQFPYEQYLAVLKKYVYNSPEWQNKTKEAAPNFAKWQQILGNRISGLNDVITVGDVLIVAQAHGKPLPKGLSQEDADQIIALTDWGLAQQFKSQKVSYIMGGKLTNRMIEDLNNAVNGKSKYKMTYYSGHALTLLEVMGTLGVPLDTAPGYASNLEMELYKDGDIYTVKLRYNGKYVKLPIMDKNNSCSLDALNKYMQSINEKFQKHHHHHH 3it3 B 1.5 BS01 3AM B 1 R16 H17 R20 F23 R84 Y135 H260 A261 R12 H13 R16 F19 R80 Y128 H253 A254 19836403 343 SSKLIFVSMITRHGDRAPFANIENANYSWGTELSELTPIGMNQEYNLGLQLRKRYIDKFGLLPEHYVDQSIYVLSSHTNRTVVSAQSLLMGLYPAGTGPLIDPAIKDRFQPIPIMTLSADSRLIQFPYEQYLAVLKKYVYNSPEWQNKTKEAAPNFAKWQQILGNRISGLNDVITVGDVLIVAQAHGKPLPKGLSQEDADQIIALTDWGLAQQFKSQKVSYIMGGKLTNRMIEDLNNAVNGKSKYKMTYYSGHALTLLEVMGTLGVPLDTAPGYASNLEMELYKDGDIYTVKLRYNGKYVKLPIMDKNNSCSLDALNKYMQSINEKFQKHHHHHH 3ocw A 1.85 BS02 3AM A 1 D64 N66 F86 W91 T124 N125 K161 Y221 D56 N58 F78 W83 T116 N117 K153 Y213 3.1.3.2 0009279 P26093 20934434 264 EEHANMQLQQQAVLGLNWMQDSGEYKALAYQAYNAAKVAFDHAKVAKGKKKAVVADLNETMLDNSPYAGWQVQNNKPFDGKDWTRWVDARQSRAVPGAVEFNNYVNSHNGKVFYVTNRKDSTEKSGTIDDMKRLGFNGVEESAFYLKKDKSAKAARFAEIEKQGYEIVLYVGDNLDDFGNTVYGKLNADRRAFVDQNQGKFGKTFIMLPNANYGGWEGGLAEGYFKKDTQGQIKARLDAVQAWDGKL 3w2v A 2.6 BS02 3AM A 1 V229 Q230 I233 S246 N300 Y669 D674 V13 Q14 I17 S30 N84 Y408 D413 F264 I270 F48 I54 ? Q8U1S6 23583914 902 KDPTLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVDKFGPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAEKIEEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVREYFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLERIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDHDNLKSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGDEEKVKEVVDFLNAAYKEIGNPPKYYAILVMDGDDTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGGDDVLAILPVDKALEVAYKIRKEFGKSFEGWKLSAGILIVHYKHPLYDALEKARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKKLLEEGVGKRFIYHVLREVDTWPKVGIDEMLKFEVIRHIRGRNKEETKELREKIYGEIKDLLEHVRGNNEVEKVRGLFTFLKIITDAEVFP 5ldo A 2.752 BS01 3AM A 1 F8 H43 T45 F48 F116 H125 T127 R130 F6 H41 T43 F46 F114 H123 T125 R128 3.1.4.58 0004113,0005524,0008081,0008664,0016787,0016874 -logKd/Ki=3.75, Kd=177uM A0A140NFI1 28141848 201 EPQRLFFAIDLPAEIREQIIHWRAKHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFQSNRPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ 8iy0 A 2.26 BS01 3AM A 1 R67 A70 T74 R66 A69 T73 ? Q6PVL0 38103556 103 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy0 B 2.26 BS01 3AM B 1 G66 R67 A70 T74 G65 R66 A69 T73 ? Q6PVL0 38103556 103 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy0 C 2.26 BS01 3AM C 1 A70 T74 A68 T72 ? Q6PVL0 38103556 103 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy0 D 2.26 BS01 3AM D 1 G66 R67 A70 T74 G64 R65 A68 T72 ? Q6PVL0 38103556 103 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy0 E 2.26 BS01 3AM E 1 R67 A70 T74 R65 A68 T72 ? Q6PVL0 38103556 103 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy0 F 2.26 BS01 3AM F 1 R67 A70 I71 T74 R65 A68 I69 T72 ? Q6PVL0 38103556 103 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy1 A 2.1 BS01 3AM A 1 G66 R67 A70 T74 G65 R66 A69 T73 ? Q6PVL0 38103556 101 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy1 B 2.1 BS01 3AM B 1 G66 R67 A70 T74 G65 R66 A69 T73 ? Q6PVL0 38103556 101 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy1 C 2.1 BS01 3AM C 1 G66 R67 A70 T74 G64 R65 A68 T72 ? Q6PVL0 38103556 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy1 D 2.1 BS01 3AM D 1 R67 A70 T74 R65 A68 T72 ? Q6PVL0 38103556 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy1 E 2.1 BS01 3AM E 1 R67 A70 T74 R65 A68 T72 ? Q6PVL0 38103556 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy1 F 2.1 BS01 3AM F 1 R67 A70 T74 R65 A68 T72 ? Q6PVL0 38103556 101 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 A 2.76 BS01 3AM A 1 G66 R67 A70 T74 G65 R66 A69 T73 ? Q6PVL0 38103556 204 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 A 2.76 BS03 3AM A 2 Y11 M81 Y10 M80 ? Q6PVL0 38103556 208 DNQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 B 2.76 BS01 3AM B 1 G66 R67 A70 I71 T74 G64 R65 A68 I69 T72 ? Q6PVL0 38103556 204 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 B 2.76 BS03 3AM B 2 Y11 M81 I84 Y9 M79 I82 ? Q6PVL0 38103556 207 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 C 2.76 BS01 3AM C 1 G66 R67 A70 T74 G64 R65 A68 T72 ? Q6PVL0 38103556 205 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 C 2.76 BS03 3AM D 2 Y11 M81 I84 Y9 M79 I82 ? Q6PVL0 38103556 206 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 D 2.76 BS02 3AM D 1 G66 R67 A70 I71 T74 G64 R65 A68 I69 T72 ? Q6PVL0 38103556 204 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 D 2.76 BS03 3AM D 2 Y11 R12 L14 I84 A88 P90 Y9 R10 L12 I82 A86 P88 ? Q6PVL0 38103556 206 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 E 2.76 BS01 3AM E 1 R67 A70 T74 R65 A68 T72 ? Q6PVL0 38103556 204 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 E 2.76 BS03 3AM F 2 Y11 M81 Y9 M79 ? Q6PVL0 38103556 206 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 F 2.76 BS02 3AM F 1 G66 R67 A70 T74 G64 R65 A68 T72 ? Q6PVL0 38103556 205 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF 8iy2 F 2.76 BS03 3AM F 2 Y11 R12 L14 I84 A88 P90 Y9 R10 L12 I82 A86 P88 ? Q6PVL0 38103556 206 NQHKKIKGYRDLSQEEIDMMNRVKELGSQFEKLIQDVSDHLRGQYNASLHNRDEITRIANAEPGRWLAIGKTDIQTGMMAIIRAIAQPDSF