3goy A 2.8 BS01 3AB A 1 Y1633 Y1646 L1701 Y94 Y107 L162 2.4.2.- 0003950 Q460N5 22343925 1 KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK 3goy B 2.8 BS01 3AB B 1 Y1633 A1635 Y1640 Y1646 Y94 A96 Y101 Y107 2.4.2.- 0003950 Q460N5 22343925 1 KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK 3goy C 2.8 BS01 3AB C 1 H1601 G1602 Y1633 A1635 S1641 Y1646 H70 G71 Y94 A96 S102 Y107 2.4.2.- 0003950 Q460N5 22343925 1 KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK 3goy D 2.8 BS01 3AB D 1 H1601 Y1633 A1635 H70 Y95 A97 2.4.2.- 0003950 Q460N5 22343925 1 KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK 3hkv A 2.1 BS01 3AB A 1 H887 G888 Y919 S927 Y932 H71 G72 Y103 S111 Y116 2.4.2.- 0003950 Q53GL7 1025 WNNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFAKRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAMDCICQPSIFVIFHDTQALPTHLITCEHVP 3hkv B 2.1 BS01 3AB B 1 H887 G888 Y919 F920 S927 Y932 H70 G71 Y102 F103 S110 Y115 2.4.2.- 0003950 Q53GL7 1 NNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFAKRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAMDCICQPSIFVIFHDTQALPTHLITCEHVP 3kcz A 2.0 BS01 3AB A 1 H428 G429 F463 S470 Y473 H205 G206 F240 S247 Y250 K264 A265 I289 F305 T307 S470 Y473 E558 K41 A42 I66 F82 T84 S247 Y250 E332 2.4.2.-,2.4.2.30 0003950 Q9UGN5 20092359 1 LGTENLYFQSMDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAHPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGILGYTLNYNEYIVYNPNQVRMRYLLKVQFNF 3kcz B 2.0 BS01 3AB B 1 H428 G429 F463 S470 Y473 H203 G204 F238 S245 Y248 K264 A265 I289 F305 T307 S470 Y473 E558 K39 A40 I64 F80 T82 S245 Y248 E327 2.4.2.-,2.4.2.30 0003950 Q9UGN5 20092359 1 TENLYFQSMDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAHPEAPITGYMFGKGIYFADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGPASDTGYTLNYNEYIVYNPNQVRMRYLLKVQFNF 3se2 C 2.3 BS01 3AB C 1 H1601 G1602 Y1633 F1634 A1635 S1641 Y1646 H70 G71 Y102 F103 A104 S110 Y115 2.4.2.- 0003950 Q460N5 22343925 4 KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK 3se2 D 2.3 BS01 3AB D 1 H1601 G1602 Y1633 S1641 Y1646 H70 G71 Y102 S110 Y115 2.4.2.- 0003950 Q460N5 22343925 3 KQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFRK 4f0d A 2.7 BS01 3AB A 1 H152 G153 Y182 L183 T184 Y193 Y254 H149 G150 Y177 L178 T179 Y188 Y219 2.4.2.- 0003950 Q8N5Y8 22661712 301 MGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDKYFVVTNNQLLRVKYLLVYSQ 4pml A 1.87 BS02 3AB A 1 H1031 G1032 Y1060 F1061 K1067 S1068 Y1071 E1138 H69 G70 Y98 F99 K105 S106 Y109 E175 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=4.52, IC50>30uM Q9H2K2 25286857 1202 KEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml B 1.87 BS02 3AB B 1 H1031 G1032 Y1060 F1061 A1062 S1068 Y1071 H76 G77 Y105 F106 A107 S113 Y116 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 NLYFQDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVGLALAEYVIYRGEQAYPEYLITYQIMRPE 4pml C 1.87 BS01 3AB C 1 H1031 G1032 Y1060 F1061 S1068 Y1071 E1138 H79 G80 Y108 F109 S116 Y119 E186 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1201 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4pml D 1.87 BS02 3AB D 1 H1031 G1032 Y1060 F1061 S1068 Y1071 E1138 H68 G69 Y97 F98 S105 Y108 E175 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 EFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4tkf A 2.6 BS03 3AB A 1 H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H70 G71 Y99 F100 A101 K106 S107 Y110 E177 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tkf C 2.6 BS03 3AB C 1 H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H79 G80 Y108 F109 A110 K115 S116 Y119 E186 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 5n3q A 1.31 BS01 3AB A 1 V57 A70 M120 Y122 L173 T183 F327 V46 A59 M109 Y111 L162 T172 F316 D166 K168 N171 D184 T201 D155 K157 N160 D173 T190 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 33021032 402 QESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 5n3q A 1.31 BS02 3AB A 2 L40 R45 I335 L29 R34 I324 D166 K168 N171 D184 T201 D155 K157 N160 D173 T190 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 33021032 403 QESVKEFLAKAKEEFLKKWESPSQNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 6fxi A 2.6 BS01 3AB A 1 H887 G888 R909 Y919 F920 A921 L926 S927 Y932 I987 H70 G71 R92 Y102 F103 A104 L109 S110 Y115 I170 2.4.2.- 0003950 Q53GL7 1101 MNLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHV 6fxi B 2.6 BS01 3AB B 1 H887 G888 R909 Y919 F920 A921 L926 S927 Y932 I987 H69 G70 R91 Y101 F102 A103 L108 S109 Y114 I169 2.4.2.- 0003950 Q53GL7 1101 NLERLAENTGEFQEVVRAFYDTLDAARSSIRVVRVERVSHPLLQQQYELYRERLLQRCERRPVEQVLYHGTTAPAVPDICAHGFNRSFCGRNATVYGKGVYFARRASLSVQDRYSPPNADGHKAVFVARVLTGDYGQGRRGLRAPPLRGPGHVLLRYDSAVDCICQPSIFVIFHDTQALPTHLITCEHV 6yiu A 1.36 BS01 3AB A 1 S190 Q192 G219 C220 S172 Q174 G196 C197 H57 D102 Q192 G193 D194 S195 G196 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 302 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 7f41 B 1.39721 BS01 3AB B 1 H559 G560 Y591 F592 A593 Y598 S599 Y604 H78 G79 Y104 F105 A106 Y111 S112 Y117 2.4.2.- 0003950 Q460N3 701 LPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCSYGKGTYFAVDASYSAKDTYSKPDNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA 8akf A 1.97 BS03 3AB A 1 I61 P62 F64 F86 N114 V115 D116 I52 P53 F55 F77 N105 V106 D107 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 409 PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE 8akf B 1.97 BS03 3AB B 1 I61 P62 F64 N114 V115 D116 I47 P48 F50 N100 V101 D102 2.3.1.-,2.3.1.286,2.4.2.- 0070403 Q8N6T7 408 KGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE