4qlt K 2.8 BS02 39V K 1 T1 A20 T21 V31 K33 G47 A49 S96 Y170 T1 A20 T21 V31 K33 G47 A49 S96 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 -logKd/Ki=8.60, IC50=2.5nM P30656 25006746 303 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qlt L 2.8 BS01 39V K 1 D126 P127 D126 P127 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 -logKd/Ki=8.60, IC50=2.5nM P23724 25006746 303 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 4qlt Y 2.8 BS02 39V Y 1 T1 R19 A20 T21 V31 K33 G47 G48 A49 S96 Y170 T1 R19 A20 T21 V31 K33 G47 G48 A49 S96 Y170 T1 D17 R19 K33 G47 S131 D168 S171 T1 D17 R19 K33 G47 S131 D168 S171 3.4.25.1 0004298,0005839,0051603 P30656 25006746 303 TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAASKILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGTRLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 4qlt Z 2.8 BS01 39V Y 1 D126 V128 D126 V128 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 25006746 303 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l5h K 2.6 BS01 39V K 1 T1 R19 A20 S21 S27 K33 G47 A49 Y169 T1 R19 A20 S21 S27 K33 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5h Y 2.6 BS02 39V Y 1 T1 R19 A20 S21 S27 K33 G47 A49 Y169 T1 R19 A20 S21 S27 K33 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5h Z 2.6 BS01 39V Y 1 S130 Q132 S130 Q132 3.4.25.1 0005839,0051603 P20618,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l5s K 2.6 BS01 39V K 1 T1 R19 A20 S21 S27 M31 K33 M45 G47 A49 S96 Y169 T1 R19 A20 S21 S27 M31 K33 M45 G47 A49 S96 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5s Y 2.6 BS02 39V Y 1 T1 R19 A20 S21 S27 M31 K33 M45 G47 C48 A49 S96 Y169 T1 R19 A20 S21 S27 M31 K33 M45 G47 C48 A49 S96 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l5s Z 2.6 BS01 39V Y 1 S124 F125 S124 F125 3.4.25.1 0005839,0051603 P20618,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l60 K 2.7 BS01 39V K 1 T1 A20 T21 V31 K33 M45 G47 A49 Y169 T1 A20 T21 V31 K33 M45 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074,P30656 27789522 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l60 L 2.7 BS01 39V K 1 D126 P127 D126 P127 3.4.25.1 0005839,0051603 P20618,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l60 Y 2.7 BS02 39V Y 1 T1 T21 K33 M45 G47 A49 S96 Y169 T1 T21 K33 M45 G47 A49 S96 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28074,P30656 27789522 301 TTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l67 K 2.6 BS01 39V K 1 T1 R19 A20 T21 S27 M31 K33 M45 G47 C48 A49 S96 Y169 T1 R19 A20 T21 S27 M31 K33 M45 G47 C48 A49 S96 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28063,P30656 27789522 301 TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l67 L 2.6 BS01 39V K 1 S124 S130 S124 S130 3.4.25.1 0005839,0051603 O09061,P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5l67 Y 2.6 BS03 39V Y 1 T1 A20 T21 S27 M31 K33 G47 C48 A49 S96 Y169 T1 A20 T21 S27 M31 K33 G47 C48 A49 S96 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28063,P30656 27789522 302 TTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5l67 Z 2.6 BS01 39V Y 1 S124 S130 S124 S130 3.4.25.1 0005839,0051603 O09061,P23724 27789522 302 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYSRRFFPYYVYNIIAGLDEDGKGAVYSFDPVGSYQREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD 5ltt K 2.7 BS01 39V K 1 T1 A20 S21 K33 G47 A49 Y169 T1 A20 S21 K33 G47 A49 Y169 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWETLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5ltt Y 2.7 BS01 39V Y 1 T1 R19 A20 S21 S27 K33 G47 A49 T1 R19 A20 S21 S27 K33 G47 A49 T1 D17 R19 K33 G47 S130 D167 S170 T1 D17 R19 K33 G47 S130 D167 S170 3.4.25.1 0004298,0005839,0051603 P28062,P30656 27789522 301 TTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWETLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVLDSNYKWDLSVEDALYLGKRSILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKVKEEEGSFNNVIG 5ltt Z 2.7 BS01 39V Y 1 S130 E132 S130 E132 3.4.25.1 0000502,0003674,0005515,0005634,0005737,0005829,0005839,0010499,0019774,0043161,0051603 P23724 27789522 301 QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHNDKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKGAVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYEPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGDGLEILIVTKDGVRKEFYELKRD