4qta A 1.45 BS01 38Z A 1 I31 A35 Y36 A52 K54 I56 Y64 T68 E71 Q105 D106 M108 E109 T110 K114 L156 C166 D167 I22 A26 Y27 A43 K45 I47 Y55 T59 E62 Q96 D97 M99 E100 T101 K105 L147 C157 D158 D149 K151 S153 N154 D167 T190 D140 K142 S144 N145 D158 T167 2.7.11.24 0000165,0001784,0003677,0004672,0004674,0004707,0005515,0005524,0005576,0005634,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006935,0006974,0007165,0007166,0007268,0007507,0007611,0008286,0008353,0009887,0010759,0010800,0014032,0014044,0016020,0016301,0016310,0018105,0018107,0019858,0019902,0030278,0030521,0030641,0030878,0031143,0031647,0031663,0032206,0032496,0032872,0033554,0033598,0034198,0035094,0035556,0035578,0038127,0038133,0042473,0042552,0042802,0043330,0043401,0045202,0045542,0045596,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060291,0060324,0060425,0060440,0060716,0061308,0070161,0070371,0070849,0071356,0072584,0072686,0090170,0106310,0120041,1904813,2000641 Kd=0.233uM -logKd/Ki=6.70, Kd~200nM P28482 25195011 411 GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADTRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY 4qtb A 1.4 BS01 38Z A 1 A52 Y53 A69 K71 I73 Y81 R84 T85 E88 Q122 D123 M125 E126 T127 K131 L173 C183 D184 A29 Y30 A46 K48 I50 Y58 R61 T62 E65 Q99 D100 M102 E103 T104 K108 L150 C160 D161 D166 K168 S170 N171 D184 T207 D143 K145 S147 N148 D161 T184 2.7.11.24 0000165,0001784,0004672,0004674,0004707,0005515,0005524,0005634,0005635,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005829,0005856,0005886,0005901,0005925,0006351,0006468,0006915,0006974,0008286,0009887,0010759,0014032,0014044,0016020,0016310,0019233,0019902,0030278,0030509,0030641,0030878,0031143,0031281,0031663,0032206,0032496,0032872,0033554,0034198,0035556,0038083,0038133,0042473,0042552,0042770,0042802,0043330,0045944,0048009,0048538,0050804,0051090,0051216,0051403,0051493,0060020,0060324,0060425,0060440,0061308,0070161,0070371,0070374,0070498,0070849,0071260,0071356,0072584,0090170,0098792,0098978,0106310,0120041,0140297,1904262,1904417,2000641 Kd=0.213uM -logKd/Ki=6.70, Kd~200nM P27361 25195011 418 VPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 4qtb B 1.4 BS01 38Z B 1 A52 Y53 A69 K71 I73 Y81 R84 T85 E88 Q122 D123 M125 E126 L173 C183 D184 A26 Y27 A43 K45 I47 Y55 R58 T59 E62 Q96 D97 M99 E100 L147 C157 D158 D166 K168 S170 N171 D184 T207 D140 K142 S144 N145 D158 T181 2.7.11.24 0000165,0001784,0004672,0004674,0004707,0005515,0005524,0005634,0005635,0005654,0005737,0005739,0005769,0005770,0005788,0005794,0005829,0005856,0005886,0005901,0005925,0006351,0006468,0006915,0006974,0008286,0009887,0010759,0014032,0014044,0016020,0016310,0019233,0019902,0030278,0030509,0030641,0030878,0031143,0031281,0031663,0032206,0032496,0032872,0033554,0034198,0035556,0038083,0038133,0042473,0042552,0042770,0042802,0043330,0045944,0048009,0048538,0050804,0051090,0051216,0051403,0051493,0060020,0060324,0060425,0060440,0061308,0070161,0070371,0070374,0070498,0070849,0071260,0071356,0072584,0090170,0098792,0098978,0106310,0120041,0140297,1904262,1904417,2000641 Kd=0.213uM P27361 25195011 412 EVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPG 4qtc A 1.4 BS01 38Z A 1 I490 G491 E492 A509 Y580 G585 S586 A587 G608 L656 I686 I22 G23 E24 A41 Y112 G117 S118 A119 G140 L188 I218 2.7.11.1 0004672,0005524,0006468 Kd=0.297uM -logKd/Ki=6.40, IC50=398nM Q8TF76 25195011 804 QKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK 4qtd A 1.5 BS01 38Z A 1 V40 A53 M108 L110 M111 D112 A113 N114 C116 Q117 Q120 S155 N156 L168 V35 A48 M103 L105 M106 D107 A108 N109 C111 Q112 Q115 S150 N151 L163 D151 K153 N156 D169 T188 D146 K148 N151 D164 T180 2.7.11.24 0004672,0004707,0005524,0006468 ic50=1080nM -logKd/Ki=5.97, IC50=1080nM P45983 25195011 424 RDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL 5hd4 A 1.45 BS01 38Z A 1 I29 A33 Y34 A50 K52 Y62 R65 T66 E69 Q103 D104 M106 E107 T108 K112 L154 D165 I21 A25 Y26 A42 K44 Y54 R57 T58 E61 Q95 D96 M98 E99 T100 K104 L146 D157 D147 K149 S151 N152 D165 T188 D139 K141 S143 N144 D157 T180 2.7.11.24 0000165,0001784,0003690,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005769,0005770,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006974,0007166,0007507,0008284,0008286,0008353,0009636,0009887,0010759,0014032,0014044,0014069,0015966,0016020,0016301,0016310,0018105,0018107,0019233,0019858,0019901,0019902,0030278,0030335,0030424,0030521,0030641,0030878,0031143,0031435,0031647,0031663,0032212,0032355,0032496,0032839,0032872,0032991,0033574,0033598,0034198,0034614,0035094,0035556,0036120,0038127,0038133,0042220,0042307,0042473,0042542,0042552,0042802,0043204,0043330,0043401,0043627,0044849,0045596,0045727,0045893,0046697,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060045,0060291,0060324,0060425,0060440,0060716,0061308,0061431,0070161,0070371,0070849,0071276,0071320,0071356,0071364,0071380,0072584,0072686,0090170,0097237,0097305,0106310,0120041,1904355,1990314,2000641 P63086 26832798 401 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPG 5hd7 A 1.69 BS01 38Z A 1 A33 Y34 A50 K52 I54 Y62 T66 E69 Q103 D104 M106 E107 T108 K112 L154 D165 D167 A25 Y26 A42 K44 I46 Y54 T58 E61 Q95 D96 M98 E99 T100 K104 L146 D157 D159 D147 K149 N152 D165 T188 D139 K141 N144 D157 T180 2.7.11.24 0000165,0001784,0003690,0004672,0004674,0004707,0005515,0005524,0005634,0005654,0005737,0005739,0005769,0005770,0005794,0005813,0005819,0005829,0005856,0005886,0005901,0005925,0006357,0006468,0006915,0006974,0007166,0007507,0008284,0008286,0008353,0009636,0009887,0010759,0014032,0014044,0014069,0015966,0016020,0016301,0016310,0018105,0018107,0019233,0019858,0019901,0019902,0030278,0030335,0030424,0030521,0030641,0030878,0031143,0031435,0031647,0031663,0032212,0032355,0032496,0032839,0032872,0032991,0033574,0033598,0034198,0034614,0035094,0035556,0036120,0038127,0038133,0042220,0042307,0042473,0042542,0042552,0042802,0043204,0043330,0043401,0043627,0044849,0045596,0045727,0045893,0046697,0048009,0048538,0050847,0050852,0050853,0051403,0051493,0060020,0060045,0060291,0060324,0060425,0060440,0060716,0061308,0061431,0070161,0070371,0070849,0071276,0071320,0071356,0071364,0071380,0072584,0072686,0090170,0097237,0097305,0106310,0120041,1904355,1990314,2000641 P63086 26832798 401 PEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFDLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPG