4qsm A 3.0 BS01 38K A 1 D52 V53 A96 G97 R99 N115 I116 F119 D51 V52 A95 G96 R98 N114 I115 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 -logKd/Ki=7.41, IC50=39nM IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQFH 4qsm B 3.0 BS01 38K B 1 D52 V53 A96 G97 I116 F119 D51 V52 A95 G96 I115 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4qsm C 3.0 BS01 38K C 1 D52 V53 A96 G97 R99 I116 F119 D51 V52 A95 G96 R98 I115 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQFH 4qsm D 3.0 BS01 38K D 1 D52 V53 A96 G97 R99 I116 F119 D51 V52 A95 G96 R98 I115 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQFH 4qsm E 3.0 BS01 38K E 1 D52 V53 A96 G97 A98 R99 F119 D51 V52 A95 G96 A97 R98 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4qsm F 3.0 BS01 38K F 1 D52 V53 A96 G97 R99 N115 I116 F119 D51 V52 A95 G96 R98 N114 I115 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4qsm G 3.0 BS01 38K G 1 D52 V53 A96 G97 N115 F119 D51 V52 A95 G96 N114 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4qsm H 3.0 BS01 38K H 1 D52 V53 A96 G97 R99 I116 F119 D51 V52 A95 G96 R98 I115 F118 R106 D166 R169 H193 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 IC50=4800nM P00338 25664730 501 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF