4tuz A 1.9 BS02 36J A 1 L346 L349 A350 E353 L387 L391 F404 M421 H524 L525 L42 L45 A46 E49 L83 L87 F100 M117 H212 L213 ? P03372 25500867 601 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL 4tuz B 1.9 BS02 36J B 1 L346 L349 A350 E353 L387 L391 F404 M421 H524 L525 L42 L45 A46 E49 L83 L87 F100 M117 H219 L220 ? P03372 25500867 601 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL 5ie4 A 2.8 BS01 36J A 1 G32 L33 A102 S103 P128 M154 V158 W183 I191 P192 G32 L33 A102 S103 P128 M154 V158 W183 I191 P192 ? 0009636,0016787 Q8NKB0 300 MRTRSTISTPNGITWYYEQEGTGPDVVLVPDGLGECQMFDSSVSQIAAQGFRVTTFDMPGMSRSAKAPPETYTEVTAQKLASYVISVLDALDIKHATVWGCASGASTVVALLLGYPDRIRNAMCHELPTKLLDHLSNTAVLEDEEISKILANVMLNDVSGGSEAWQAMGDEVHARLHKNYPVWARGYPRTIPPSAPVKDLEALRGKPLDWTVGAATPTESFFDNIVTATKAGVNIGLLPGMHFPYVSHPDVFAKYVVETTQKHL 5ie4 B 2.8 BS01 36J B 1 G32 L33 A102 S103 M154 V158 W183 I191 P192 H242 G32 L33 A102 S103 M154 V158 W183 I191 P192 H242 ? 0009636,0016787 Q8NKB0 301 MRTRSTISTPNGITWYYEQEGTGPDVVLVPDGLGECQMFDSSVSQIAAQGFRVTTFDMPGMSRSAKAPPETYTEVTAQKLASYVISVLDALDIKHATVWGCASGASTVVALLLGYPDRIRNAMCHELPTKLLDHLSNTAVLEDEEISKILANVMLNDVSGGSEAWQAMGDEVHARLHKNYPVWARGYPRTIPPSAPVKDLEALRGKPLDWTVGAATPTESFFDNIVTATKAGVNIGLLPGMHFPYVSHPDVFAKYVVETTQKHL 5ie5 A 2.39 BS01 36J A 1 G32 A102 S103 H153 M154 W183 P188 I191 P192 H242 G32 A102 S103 H153 M154 W183 P188 I191 P192 H242 ? 0009636,0016787 Q8NKB0 300 MRTRSTISTPNGITWYYEQEGTGPDVVLVPDGLGECQMFDSSVSQIAAQGFRVTTFDMPGMSRSAKAPPETYTEVTAQKLASYVISVLDALDIKHATVWGCASGASTVVALLLGYPDRIRNAMCHELPTKLLDHLSNTAVLEDEEISKILANHMLNDVSGGSEAWQAMGDEVHARLHKNYPVWARGYPRTIPPSAPVKDLEALRGKPLDWTVGAATPTESFFDNIVTATKAGVNIGLLPGMHFPYVSHPDVFAKYVVETTQKHL 5ie5 B 2.39 BS01 36J B 1 G32 A102 S103 P128 L135 M154 W183 P192 H242 G32 A102 S103 P128 L135 M154 W183 P192 H242 ? 0009636,0016787 Q8NKB0 301 MRTRSTISTPNGITWYYEQEGTGPDVVLVPDGLGECQMFDSSVSQIAAQGFRVTTFDMPGMSRSAKAPPETYTEVTAQKLASYVISVLDALDIKHATVWGCASGASTVVALLLGYPDRIRNAMCHELPTKLLDHLSNTAVLEDEEISKILANHMLNDVSGGSEAWQAMGDEVHARLHKNYPVWARGYPRTIPPSAPVKDLEALRGKPLDWTVGAATPTESFFDNIVTATKAGVNIGLLPGMHFPYVSHPDVFAKYVVETTQKHL 5xo7 A 1.88 BS01 36J A 1 G35 L36 A105 S106 P131 N134 L138 M153 S157 Y160 W185 P190 I193 P194 H243 G32 L33 A102 S103 P128 N131 L135 M150 S154 Y157 W182 P187 I190 P191 H240 ? -logKd/Ki=6.36, Kd=0.44uM A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 B 1.88 BS01 36J B 1 G35 L36 A105 S106 N134 W185 I193 P194 H243 G32 L33 A102 S103 N131 W182 I190 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 C 1.88 BS01 36J C 1 G35 L36 A105 S106 P131 N134 Y160 W185 I193 P194 G32 L33 A102 S103 P128 N131 Y157 W182 I190 P191 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 D 1.88 BS01 36J D 1 D34 G35 A105 S106 N134 L138 S157 Y160 W185 I193 P194 H243 D31 G32 A102 S103 N131 L135 S154 Y157 W182 I190 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5xo7 E 1.88 BS01 36J E 1 G35 L36 A105 S106 P131 N134 P135 L138 M153 S157 Y160 W185 I193 P194 H243 G32 L33 A102 S103 P128 N131 P132 L135 M150 S154 Y157 W182 I190 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 F 1.88 BS01 36J F 1 G35 L36 A105 S106 N134 M153 W185 I193 P194 H243 G33 L34 A103 S104 N132 M151 W183 I191 P192 H241 ? A0A0D2ILK1 301 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 G 1.88 BS01 36J G 1 G35 L36 A105 S106 N134 Y160 W185 I193 P194 H243 G32 L33 A102 S103 N131 Y157 W182 I190 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5xo7 H 1.88 BS01 36J H 1 G35 L36 A105 S106 P131 N134 Y160 W185 I193 P194 H243 G32 L33 A102 S103 P128 N131 Y157 W182 I190 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAYSGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j A 1.98 BS01 36J A 1 G35 L36 A105 S106 S157 W185 P190 I193 P194 H243 G32 L33 A102 S103 S154 W182 P187 I190 P191 H240 ? -logKd/Ki=6.60, Kd=0.25uM A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j B 1.98 BS01 36J B 1 G35 L36 A105 S106 P131 N134 N156 W185 P190 I193 P194 H243 G32 L33 A102 S103 P128 N131 N153 W182 P187 I190 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j C 1.98 BS01 36J C 1 G35 L36 A105 S106 N134 S157 W185 I193 P194 H243 G33 L34 A103 S104 N132 S155 W183 I191 P192 H241 ? A0A0D2ILK1 301 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j D 1.98 BS01 36J D 1 G35 L36 A105 S106 N134 W185 I193 P194 H243 G33 L34 A103 S104 N132 W183 I191 P192 H241 ? A0A0D2ILK1 301 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j E 1.98 BS01 36J E 1 G35 A105 S106 N134 L138 W185 P194 H243 G33 A103 S104 N132 L136 W183 P192 H241 ? A0A0D2ILK1 301 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5z7j F 1.98 BS01 36J F 1 G35 L36 A105 S106 P131 N134 W185 P194 H243 G32 L33 A102 S103 P128 N131 W182 P191 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 5z7j G 1.98 BS01 36J G 1 G35 L36 A105 S106 N156 S157 W185 P194 F222 H243 G33 L34 A103 S104 N154 S155 W183 P192 F220 H241 ? A0A0D2ILK1 301 ATRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYL 5z7j H 1.98 BS01 36J H 1 G35 L36 A105 S106 N134 M153 N156 S157 W185 P194 F222 H243 G32 L33 A102 S103 N131 M150 N153 S154 W182 P191 F219 H240 ? A0A0D2ILK1 301 TRTRGYVTTKDGIKWYYEQEGSGPDVVLIPDGLGECQMFDKPMSLIASNGFRVTTFDMPGMSRSSDAPPETYQDITGRKLAGYIITLLDTLDIKIASVWGCASGASTVLALCSDYPERVRNGMPHEVPTENPDILLHIHEVDPATISQEMAANSRAASGNVEAWDALGPEVHARLHDNYPRWAYGYPRTIPPSAPVKTEDLHKVPIDWTVGASTPTKLFFENIVIAAREGINIGTLPGNHFPYVSHPEEFAKYVVETSRKYLK 6jr2 A 1.65 BS01 36J A 1 G32 S102 S103 V158 W183 I191 P192 G32 S102 S103 V158 W183 I191 P192 ? A0A0N9XBU7 301 MRTRSTISTPNGITWYYEQEGTGPDIVLVPDGLGECQMFDSSVSQIAAQGFRVTTFDMPGMSRSAKAPAETYTEVTAQKLASYVISILDALDIKHATVWGCSSGASTVVALLLGYPDRIRNAMCHELPTKLLDHLSNTAVLEDEEISNILANVMLNDVSGGSEAWQALGVEVHARLHKNYPVWARGYPRTIPPSAPVQDVEALRGKPLDWTVGAATPTESFFDNIVTATKAGVNIGLLPGMAFPYVSHPDVFAKYVVETTQKHLWNSS 6jr2 B 1.65 BS01 36J B 1 G32 S102 S103 E126 L135 V158 W183 I191 P192 F221 A242 G32 S102 S103 E126 L135 V158 W183 I191 P192 F221 A242 ? A0A0N9XBU7 301 MRTRSTISTPNGITWYYEQEGTGPDIVLVPDGLGECQMFDSSVSQIAAQGFRVTTFDMPGMSRSAKAPAETYTEVTAQKLASYVISILDALDIKHATVWGCSSGASTVVALLLGYPDRIRNAMCHELPTKLLDHLSNTAVLEDEEISNILANVMLNDVSGGSEAWQALGVEVHARLHKNYPVWARGYPRTIPPSAPVQDVEALRGKPLDWTVGAATPTESFFDNIVTATKAGVNIGLLPGMAFPYVSHPDVFAKYVVETTQKHLWNSS