4qmm A 1.852 BS01 35R A 1 I30 G31 K32 A51 L102 G105 L151 I22 G23 K24 A43 L94 G97 L143 D144 K146 A148 N149 D162 D171 T182 D136 K138 A140 N141 D154 D163 T174 2.7.11.1 0004672,0005524,0006468 ic50=0.46uM -logKd/Ki=6.34, IC50=0.46uM Q9Y6E0 27135311 401 GLPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAE 5n23 A 2.088 BS02 35R A 1 L49 G50 A70 E121 Y122 A123 G126 S130 L173 F327 L42 G43 A63 E114 Y115 A116 G119 S123 L166 F314 D166 K168 N171 D184 T201 D159 K161 N164 D177 T194 2.7.11.11 0004672,0004674,0005524,0006468 P17612 401 KGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIRTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRIQQAVNFPFLVKLEFSFKDNSNLYMVLEYAPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIKVADFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFSNFDDYEEEEIRVSINEKCGKEFSEF 5ut0 A 2.102 BS01 35R A 1 L551 L579 F628 V629 K630 F631 G632 L680 L15 L43 F92 V93 K94 F95 G96 L144 N673 K677 N678 D699 N137 K141 N142 D163 2.7.10.2 0004672,0005524,0006468 -logKd/Ki=5.88, Kd=1323nM Kd=11nM O60674 28626521 903 FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSL 5wim A 2.55 BS01 35R A 1 L551 L579 V629 F631 G632 N678 L680 S698 L16 L44 V94 F96 G97 N143 L145 S163 N673 K677 N678 D699 N138 K142 N143 D164 2.7.10.2 0004672,0005524,0006468 Kd=11nM O60674 30763067 901 VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSLF 6cpg A 2.8 BS01 35R A 1 L139 V147 A160 E211 A213 G216 L13 V21 A34 E85 A87 G90 D256 K258 E260 N261 D274 T292 D130 K132 E134 N135 D148 T154 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 O14965 29901437 501 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANS 6cpg D 2.8 BS01 35R D 1 L139 A213 P214 G216 R220 L263 L13 A87 P88 G90 R94 L137 D256 K258 E260 N261 D274 T292 D130 K132 E134 N135 D148 T156 2.7.11.1 0000212,0000226,0000278,0004672,0005524,0006468,0007052,0007098,0007100,0051321 O14965 29901437 501 QWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSS 6d2i A 3.192 BS01 35R A 1 L551 L579 K581 F628 V629 F631 G632 L680 L16 L44 K46 F93 V94 F96 G97 L145 N673 K677 N678 D699 N138 K142 N143 D164 2.7.10.2 0004672,0005524,0006468 Kd=11nM O60674 30763067 901 VFHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSL 6d2i B 3.192 BS01 35R B 1 L579 K581 V629 K630 F631 G632 L680 L43 K45 V93 K94 F95 G96 L144 N673 K677 N678 D699 N137 K141 N142 D163 2.7.10.2 0004672,0005524,0006468 Kd=11nM O60674 30763067 901 FHKIRNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMSKLSHKHLVLNYGVCFCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAAAMHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKAAELANLINNCMDYEPDHRPSFRAIIRDLNSL