4qmv A 2.4 BS01 34W A 1 E28 I30 V38 E100 L102 G105 L151 Y291 E19 I21 V29 E91 L93 G96 L142 Y282 D144 K146 A148 N149 D162 D171 T182 D135 K137 A139 N140 D153 D162 T173 2.7.11.1 0004672,0005524,0006468 ic50=0.023uM -logKd/Ki=7.64, IC50=0.023uM Q9Y6E0 27135311 401 LPGMQNLKADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYKRWKAEQ 5vd2 A 2.05 BS01 34W A 1 E303 I305 F310 A326 E377 Y378 C379 G382 F433 E11 I13 F18 A34 E85 Y86 C87 G90 F141 D426 K428 D134 K136 2.7.10.2 0004672,0005524,0006468 -logKd/Ki=7.10, Kd=78.7nM P30291 28792760 601 SRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVL 6qas A 1.75 BS01 34W A 1 I22 G23 V30 A44 M92 Y94 C95 G98 L145 I15 G16 V23 A37 M85 Y87 C88 G91 L138 D138 K140 Q142 N143 D165 S184 D131 K133 Q135 N136 D158 S177 2.7.11.1 0004672,0004674,0005524,0006468,0010506 O75385 30782972 318 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDAS 6qas B 1.75 BS01 34W B 1 I22 G23 V30 A44 M92 E93 Y94 C95 G98 L145 I15 G16 V23 A37 M85 E86 Y87 C88 G91 L138 D138 K140 Q142 N143 D165 S184 D131 K133 Q135 N136 D158 S177 2.7.11.1 0004672,0004674,0005524,0006468,0010506 O75385 30782972 315 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDA 6qas B 1.75 BS02 34W B 2 G97 D99 D102 Y103 A106 M107 R153 A154 G90 D92 D95 Y96 A99 M100 R146 A147 D138 K140 Q142 N143 D165 S184 D131 K133 Q135 N136 D158 S177 2.7.11.1 0004672,0004674,0005524,0006468,0010506 O75385 30782972 316 TETVGKFEFSRKDLIGHGAFAVVFKGRHRAAHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDA