4tn4 A 2.2 BS02 33G A 1 L124 G127 G128 T183 N354 K355 N356 L124 G127 G128 T183 N354 K355 N356 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=6.33, IC50=470nM A5K8L9 25785478 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tn4 A 2.2 BS04 33G B 1 E56 Y63 Y64 E56 Y63 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=6.33, IC50=470nM A5K8L9 25785478 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tn4 B 2.2 BS02 33G A 1 E56 Y63 Y64 E56 Y63 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=6.33, IC50=470nM A5K8L9 25785478 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tn4 B 2.2 BS04 33G B 1 L124 G128 T183 N354 K355 R371 L124 G128 T183 N354 K355 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=6.33, IC50=470nM A5K8L9 25785478 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 4tn4 C 2.2 BS02 33G C 1 L124 G127 G128 H129 T183 N354 K355 L124 G127 G128 H129 T183 N354 K355 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 25785478 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP