4tki A 2.15 BS02 33E A 1 H1031 G1032 Y1050 Y1060 S1068 Y1071 H70 G71 Y89 Y99 S107 Y110 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=6.38, IC50=0.416uM Q9H2K2 25286857 1202 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki A 2.15 BS03 33E A 2 F1035 A1038 I1039 H1048 F74 A77 I78 H87 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=6.38, IC50=0.416uM Q9H2K2 25286857 1203 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki A 2.15 BS04 33E A 3 K999 C1001 N1002 K1003 W1006 Y1148 E1150 K38 C40 N41 K42 W45 Y187 E189 2.4.2.-,2.4.2.30 0003950 -logKd/Ki=6.38, IC50=0.416uM Q9H2K2 25286857 1204 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki B 2.15 BS02 33E B 1 F1035 H1048 F79 H92 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 LYFQGDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki B 2.15 BS03 33E B 2 H1031 G1032 Y1050 Y1060 F1061 S1068 Y1071 H75 G76 Y94 Y104 F105 S112 Y115 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 LYFQGDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki C 2.15 BS02 33E C 1 H1031 G1032 Y1050 Y1060 F1061 A1062 S1068 Y1071 H79 G80 Y98 Y108 F109 A110 S116 Y119 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki C 2.15 BS03 33E C 2 F1035 I1039 G1043 H1048 F83 I87 G91 H96 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 NLYFQGSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRP 4tki D 2.15 BS02 33E D 1 H1031 G1032 Y1060 F1061 S1068 Y1071 E1138 H70 G71 Y97 F98 S105 Y108 E171 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1202 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPLALAEYVIYRGEQAYPEYLITYQIMRP 4tki D 2.15 BS03 33E D 2 F1035 I1039 G1043 H1048 F74 I78 G82 H87 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1203 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPLALAEYVIYRGEQAYPEYLITYQIMRP 4tki D 2.15 BS04 33E D 3 C1001 K1003 W1006 Y1148 E1150 C40 K42 W45 Y181 E183 2.4.2.-,2.4.2.30 0003950 Q9H2K2 25286857 1204 DKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPLALAEYVIYRGEQAYPEYLITYQIMRP 7f42 A 1.41 BS01 33E A 1 H559 G560 Y591 A593 Y598 S599 Y604 L659 H81 G82 Y113 A115 Y120 S121 Y126 L181 2.4.2.- 0003950 Q460N3 701 TCNLPEHWTDMNHQLFCMVQLEPGQSEYNTIKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSVPYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGVFTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA