3c4c A 2.57 BS01 324 A 1 A481 K483 L514 I527 T529 Q530 W531 C532 F583 D594 F595 A34 K36 L67 I80 T82 Q83 W84 C85 F136 D147 F148 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S152 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=6.80, IC50=160nM IC50=13nM, Ki=2.6nM, Kd=100nM P15056 18287029 2 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 3c4c B 2.57 BS01 324 B 1 V471 A481 K483 E501 L505 L514 I527 T529 F583 D594 V24 A34 K36 E54 L58 L67 I80 T82 F136 D147 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S151 2.7.11.1 0004672,0005524,0006468 IC50=13nM, Ki=2.6nM, Kd=100nM P15056 18287029 3 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFSGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELARELS 4wo5 A 2.83 BS01 324 A 1 V471 A481 K483 L505 L514 T529 Q530 W531 C532 F583 D594 F595 G596 V24 A34 K36 L58 L67 T82 Q83 W84 C85 F135 D146 F147 G148 D576 K578 N580 N581 D594 S616 D128 K130 N132 N133 D146 S164 2.7.11.1 0004672,0005524,0006468 IC50=13nM, Ki=2.6nM, Kd=100nM P15056 25437913 801 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASEKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATVKSRWSFEQLSGSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL 4wo5 B 2.83 BS01 324 B 1 V471 A481 K483 L514 T529 Q530 W531 C532 F583 D594 F595 V22 A32 K34 L65 T80 Q81 W82 C83 F134 D145 F146 D576 K578 N580 N581 D594 S616 D127 K129 N131 N132 D145 S152 2.7.11.1 0004672,0005524,0006468 IC50=13nM, Ki=2.6nM, Kd=100nM P15056 25437913 801 WEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHASETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIGDFGLATGSILWMAPEVIRMQDSNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFPRILAEIEELAREL