4ele A 2.35 BS02 31I A 1 M6 V7 A8 L21 E28 L29 V32 K33 R53 L55 P56 R58 F96 M6 V7 A8 L21 E28 L29 V32 K33 R53 L55 P56 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM -logKd/Ki=7.88, Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele B 2.35 BS02 31I B 1 M6 V7 A8 N20 L21 E28 L29 V32 K33 A50 I51 R53 L55 P56 R58 F96 M6 V7 A8 N20 L21 E28 L29 V32 K33 A50 I51 R53 L55 P56 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele C 2.35 BS02 31I C 1 M6 V7 A8 L21 E28 L29 V32 K33 I51 R53 L55 P56 F96 M6 V7 A8 L21 E28 L29 V32 K33 I51 R53 L55 P56 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele D 2.35 BS02 31I D 1 M6 V7 A8 L21 E28 L29 V32 K33 L55 P56 R58 F96 M6 V7 A8 L21 E28 L29 V32 K33 L55 P56 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele E 2.35 BS02 31I E 1 M6 V7 A8 L21 E28 L29 V32 K33 A50 I51 L55 P56 F96 M6 V7 A8 L21 E28 L29 V32 K33 A50 I51 L55 P56 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele F 2.35 BS02 31I F 1 M6 V7 A8 L21 E28 L29 V32 K33 I51 R53 L55 R58 F96 M6 V7 A8 L21 E28 L29 V32 K33 I51 R53 L55 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele G 2.35 BS02 31I G 1 M6 V7 A8 N20 L21 E28 L29 V32 K33 L55 R58 F96 M6 V7 A8 N20 L21 E28 L29 V32 K33 L55 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 203 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR 4ele H 2.35 BS01 31I H 1 M6 V7 A8 N20 L21 E28 L29 V32 K33 I51 R53 L55 P56 R58 F96 M6 V7 A8 N20 L21 E28 L29 V32 K33 I51 R53 L55 P56 R58 F96 M6 L21 W23 E28 L29 V32 L55 I93 T115 M6 L21 W23 E28 L29 V32 L55 I93 T115 1.5.1.3 0000166,0004146,0005829,0006730,0016491,0046452,0046654,0046655,0046872,0050661 Ki=13.2nM Q81R22 22999981 201 MIVSFMVAMDENRVIGKDNNLPWRLPSELQYVKKTTMGHPLIMGRKNYEAIGRPLPGRRNIIVTRNEGYHVEGCEVAHSVEEVFELCKNEEEIFIFGGAQIYDLFLPYVDKLYITKIHHAFEGDTFFPEMDMTNWKEVFVEKGLTDEKNPYTYYYHVYEKQQLVPR