4pp7 A 3.4 BS01 2VX A 1 V471 A481 K483 L505 L514 I527 T529 W531 C532 F583 D594 F595 G596 V24 A34 K36 L58 L67 I80 T82 W84 C85 F136 D147 F148 G149 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S162 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.96, IC50=11nM IC50=62nM P15056 24675381 801 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL 4pp7 B 3.4 BS01 2VX B 1 A481 K483 L505 L514 T529 W531 C532 D594 F595 G596 A34 K36 L58 L67 T82 W84 C85 D147 F148 G149 D576 K578 N580 N581 D594 S616 D129 K131 N133 N134 D147 S169 2.7.11.1 0004672,0005524,0006468 IC50=62nM P15056 24675381 801 DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSL