4ogj A 1.65 BS01 2TA A 1 W81 P82 F83 L92 L94 N140 W40 P41 F42 L51 L53 N99 ? Kd=164nM -logKd/Ki=6.79, Kd=164nM Kd=164nM, IC50=290nM O60885 24584101 203 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ogj A 1.65 BS02 2TA B 1 D145 M149 D104 M108 ? Kd=164nM -logKd/Ki=6.79, Kd=164nM Kd=164nM, IC50=290nM O60885 24584101 202 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ogj B 1.65 BS01 2TA A 1 F79 D145 M149 F38 D104 M108 ? Kd=164nM Kd=164nM, IC50=290nM O60885 24584101 203 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ogj B 1.65 BS02 2TA B 1 W81 P82 F83 V87 L94 N140 I146 W40 P41 F42 V46 L53 N99 I105 ? Kd=164nM Kd=164nM, IC50=290nM O60885 24584101 202 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ps5 A 1.4 BS01 2TA A 1 W81 P82 F83 V87 L92 L94 N140 I146 W40 P41 F42 V46 L51 L53 N99 I105 ? ic50=0.29uM -logKd/Ki=6.54, IC50=0.29uM Kd=164nM, IC50=290nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 4ps5 B 1.4 BS01 2TA B 1 P82 F83 L92 L94 N140 P41 F42 L51 L53 N99 ? ic50=0.29uM Kd=164nM, IC50=290nM O60885 24568369 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 6vne A 2.32 BS01 2TA A 1 L855 G858 A880 M929 Y931 L932 G935 L983 D994 L16 G19 A41 M90 Y92 L93 G96 L144 D155 D976 R980 N981 D994 D137 R141 N142 D155 2.7.10.2 0004672,0004713,0005524,0006468 IC50=3.0nM, Kd=1.1nM O60674 33570945 1201 DPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 6vne B 2.32 BS01 2TA B 1 Q853 L855 V863 A880 Y931 L932 G935 N981 L983 Q11 L13 V21 A38 Y89 L90 G93 N139 L141 D976 R980 N981 D994 D134 R138 N139 D152 2.7.10.2 0004672,0004713,0005524,0006468 IC50=3.0nM, Kd=1.1nM O60674 33570945 1201 QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMA 8xv9 A 3.8 BS01 2TA A 1 E32 L35 W59 W94 E110 Y113 Y151 L296 N297 E22 L25 W49 W84 E100 Y103 Y141 L225 N226 ? 0005506,0005515,0005886,0009055,0009229,0015234,0015888,0016020,0020037,0022900,0031923,0042597,0042723,0046872,0051180,0055085,0071705,0071934,0090482 P0ABE7,Q9BZV2 38503960 501 SWIYPTVILCLFGFFSMMRPSEPFLIPYLSGPDKNLTSAEITNEIFPVWTYSYLVLLLPVFVLTDYVRYKPVIILQGISFIITWLLLLFGQGVKTMQVVEFFYGMVTAAEVAYYAYIYSVVSPEHYQRVSGYCRSVTLAAYTAGSVLAQLLVSLANMSYFYLNVISLASVSVAFLFSLFLPMPKKSMFFHAKPWFQDLKECYSSKRLFYWSLWWAFATAGFNQVLNYVQILWDYKAPSQDSSIYNGAVEAIATFGGAVAAFAVGYVKVNWDLLGELALVVFSVVNAGSLFLMHYTANIWACYAGYLIFKSSYMLLITIAVFQIAVNLNVERYALVFGINTFIALVIQTIMTVIVVDQRGLNLPVSIQFLVYGSYFAVIAGIFLMRSMY