4o0t A 2.6 BS01 2OL A 1 V284 A297 K299 E315 M319 M344 Y346 L347 L396 T406 D407 F408 V34 A47 K49 E65 M69 M94 Y96 L97 L146 T156 D157 F158 N389 K391 D393 N394 D407 T427 N139 K141 D143 N144 D157 T177 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=5.54, Ki=2.9uM IC50=5420nM, Ki=2900nM Q13153 24432870 601 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSEMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 4o0v A 2.8 BS01 2OL A 1 I327 V335 K350 E366 V379 M395 L398 G401 L447 S457 D458 F459 I29 V37 K52 E68 V81 M97 L100 G103 L149 S159 D160 F161 D440 K442 D444 S445 D458 K467 T478 D142 K144 D146 S147 D160 K169 T180 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=8.48, Ki=3.3nM IC50=4.8nM, Ki=3.3nM O96013 24432870 601 GSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR