4nr7 A 1.2 BS01 2LO A 1 P1110 V1115 L1120 N1168 R1173 V1174 F1177 P29 V34 L39 N87 R92 V93 F96 2.3.1.-,2.3.1.48 0004402,0006355 Kd=21nM, IC50=2800nM, EC50=6900nM Q92793 1204 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG 5bt3 A 1.05 BS01 2LO A 1 P1074 Q1077 V1079 L1084 R1137 V1138 Y1141 P27 Q30 V32 L37 R90 V91 Y94 2.3.1.-,2.3.1.48 0004402,0006355 Kd=31847134nM, IC50=230nM Q09472 1201 IFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLG 5bt4 A 1.5 BS01 2LO A 1 W81 P82 L92 N140 I146 W40 P41 L51 N99 I105 ? Kd=8.5e+2nM, IC50=7121nM O60885 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE 5bt4 B 1.5 BS01 2LO B 1 W81 Q84 W40 Q43 ? Kd=8.5e+2nM, IC50=7121nM O60885 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 5bt4 B 1.5 BS02 2LO C 1 W81 P82 L92 I146 W40 P41 L51 I105 ? Kd=8.5e+2nM, IC50=7121nM O60885 201 SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 5bt4 C 1.5 BS01 2LO B 1 K91 L92 N140 I146 K48 L49 N97 I103 ? Kd=8.5e+2nM, IC50=7121nM O60885 201 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 5bt4 C 1.5 BS02 2LO C 1 W81 P82 Q84 Q85 W38 P39 Q41 Q42 ? Kd=8.5e+2nM, IC50=7121nM O60885 201 NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE 5bt5 A 1.4 BS01 2LO A 1 W370 P371 F372 L381 V435 W25 P26 F27 L36 V90 ? P25440 505 LSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPD 6bya A 2.26 BS01 2LO A 1 H26 I28 V33 N90 A95 Y96 H25 I27 V32 N89 A94 Y95 ? A0A3Q8I8I6 201 NLYFQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEHN 6bya B 2.26 BS01 2LO B 1 H26 H27 I28 V33 Y37 N90 A95 Y96 H27 H28 I29 V34 Y38 N91 A96 Y97 ? A0A3Q8I8I6 201 HHHHHFQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEHN 6bya C 2.26 BS01 2LO C 1 H26 I28 V33 T36 Y37 N90 A95 Y96 H24 I26 V31 T34 Y35 N88 A93 Y94 ? A0A3Q8I8I6 1000 LYFQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEHN 6bya D 2.26 BS01 2LO D 1 H26 I28 Y44 Y96 H25 I27 Y43 Y95 ? A0A3Q8I8I6 1000 NLYFQGYNEADVAALVRSLDRAEDHHIFAVDVLETYPYLAESYTKVCPRRCDLATAAQKALEGAYSYDLRLEGLKADIALMASNCVAYNGPTSAYAETAAKFERYALEQIDAFVLEH 7ugl A 1.5 BS02 2LO A 1 L1109 P1110 L1120 N1168 R1173 V1174 F1177 L28 P29 L39 N87 R92 V93 F96 2.3.1.-,2.3.1.48 0004402,0006355 Q92793 1202 KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG 7ugl B 1.5 BS03 2LO B 1 L1109 P1110 F1111 L1120 Y1167 N1168 V1174 F1177 L27 P28 F29 L38 Y85 N86 V92 F95 2.3.1.-,2.3.1.48 0004402,0006355 Q92793 1202 KIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG