4p90 A 2.49 BS01 2K0 A 1 I276 V284 A297 K299 M344 Y346 L347 L396 D407 I27 V35 A42 K44 M79 Y81 L82 L131 D142 N389 K391 D393 N394 D407 T427 N124 K126 D128 N129 D142 T157 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=7.19, IC50=64nM Q13153 601 DEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMEVAIKQMKELIINEILVMRENKNPNIVNYLDSYLELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFGFCAQIKRSEMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 4p90 B 2.49 BS01 2K0 B 1 A297 K299 V328 M344 E345 Y346 L347 G350 L396 D407 A37 K39 V59 M75 E76 Y77 L78 G81 L127 D138 N389 K391 D393 N394 D407 T427 N120 K122 D124 N125 D138 T147 2.7.11.1 0004672,0005524,0006468 Q13153 601 LRSIVSVGDPKKKYTRFEKIGGTVYTAMDVATGQEVAIKQMNLINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDSKRSEMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK