4nbl A 1.756 BS01 2J6 A 1 Y198 T199 L200 P201 Y164 T165 L166 P167 P62 E63 H121 G122 A163 R164 P39 E40 H98 G99 A140 R141 3.4.22.59 0002218,0004175,0004197,0005515,0005634,0005654,0005737,0005829,0006508,0006915,0008234,0016540,0030855,0042802,0043065,0043067,0043525,0051604,0060545,0070269,0072332,0072734,0097153,0097194,0097200,0097284 Kd=0.47uM -logKd/Ki=6.33, Kd=0.47uM Kd=470nM P55212 24259468 401 AFYKREMFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAARGNQHDVPVIPDTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKS 4nbl B 1.756 BS01 2J6 A 1 A195 S196 V197 Y198 T199 E214 A146 S147 V148 Y149 T150 E165 P62 E63 H121 G122 A163 R164 P33 E34 H92 G93 A134 R135 3.4.22.59 0002218,0004175,0004197,0005515,0005634,0005654,0005737,0005829,0006508,0006915,0008234,0016540,0030855,0042802,0043065,0043067,0043525,0051604,0060545,0070269,0072332,0072734,0097153,0097194,0097200,0097284 -logKd/Ki=6.33, Kd=0.47uM Kd=470nM P55212 24259468 401 MFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAARGNTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPK 8f78 A 2.65 BS01 2J6 A 1 V197 Y198 T199 L200 E214 V149 Y150 T151 L152 E166 3.4.22.59 0002218,0004175,0004197,0005515,0005634,0005654,0005737,0005829,0006508,0006915,0008234,0016540,0030855,0042802,0043065,0043067,0043525,0051604,0060545,0070269,0072332,0072734,0097153,0097194,0097200,0097284 P55212 37406165 301 MFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAARGNQTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSNENLYFQ 8f78 B 2.65 BS01 2J6 A 1 Y198 L200 P201 Y150 L152 P153 3.4.22.59 0002218,0004175,0004197,0005515,0005634,0005654,0005737,0005829,0006508,0006915,0008234,0016540,0030855,0042802,0043065,0043067,0043525,0051604,0060545,0070269,0072332,0072734,0097153,0097194,0097200,0097284 P55212 37406165 301 MFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAARGNQTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSNENLYFQ 8f78 C 2.65 BS01 2J6 C 1 S196 V197 Y198 T199 E214 S149 V150 Y151 T152 E167 3.4.22.59 0002218,0004175,0004197,0005515,0005634,0005654,0005737,0005829,0006508,0006915,0008234,0016540,0030855,0042802,0043065,0043067,0043525,0051604,0060545,0070269,0072332,0072734,0097153,0097194,0097200,0097284 P55212 37406165 301 MFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAARGNQHTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSN 8f78 D 2.65 BS01 2J6 C 1 Y198 L200 Y149 L151 3.4.22.59 0002218,0004175,0004197,0005515,0005634,0005654,0005737,0005829,0006508,0006915,0008234,0016540,0030855,0042802,0043065,0043067,0043525,0051604,0060545,0070269,0072332,0072734,0097153,0097194,0097200,0097284 P55212 37406165 301 MFDPAEKYKMDHRRRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHEVSTVSHADADCFVCVFLSHGEGNHIYAYDAKIEIQTLTGLFKGDKCHSLVGKPKIFIIQAARGNTNITEVDAASVYTLPAGADFLMCYSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQVPCFASMLTKKLHFFPKSNENL