1pke A 2.3 BS02 2FD A 1 S90 C91 F159 V178 E179 M180 E181 D204 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 446 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke B 2.3 BS02 2FD B 1 M64 S90 C91 G92 F159 V178 M180 E181 D204 M64 S90 C91 G92 F159 V178 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 447 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pke C 2.3 BS02 2FD C 1 M64 S90 C91 F159 V178 E179 M180 E181 D204 M64 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 448 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTQTTFNDMIKIALESVLLGDK 1z34 A 2.4 BS01 2FD A 1 M64 T90 C91 G92 F159 V178 M180 E181 M64 T90 C91 G92 F159 V178 M180 E181 0003824,0004731,0006139,0009116 ic50=0.42mM -logKd/Ki=3.38, IC50=0.42mM 15817485 300 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEERQNSFQNMMKIALEAAIKL 3ggs A 2.52 BS01 2FD A 1 Y88 A116 G118 F200 V217 M219 D243 Y86 A114 G116 F198 V215 M217 D241 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S31 H62 H84 Y86 E87 A114 M217 S218 D241 V243 H255 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPD 3ggs B 2.52 BS01 2FD B 1 A116 G118 F200 Q201 V217 M219 D243 A116 G118 F200 Q201 V217 M219 D243 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S33 H64 H86 Y88 E89 A116 M219 S220 D243 V245 H257 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP 3ggs C 2.52 BS01 2FD C 1 S33 A116 G118 F200 Q201 V217 M219 D243 S31 A110 G112 F194 Q195 V211 M213 D237 S33 H86 Y88 E89 A116 M219 S220 D243 V245 H257 S31 H80 Y82 E83 A110 M213 S214 D237 V239 H251 2.4.2.1 0000255,0001882,0002060,0003824,0004731,0005515,0005576,0005737,0005829,0006139,0006148,0006149,0006157,0006166,0006204,0006738,0006955,0009116,0009165,0009410,0016757,0016763,0032743,0034418,0034774,0042102,0042301,0042802,0043101,0046059,0046638,0047975,0070062,1904813 P00491 19388075 300 NGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFQTVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITDKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLP