1pk9 A 1.9 BS02 2FA A 1 M64 S90 C91 F159 V178 E179 M180 E181 D204 M64 S90 C91 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 306 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 B 1.9 BS02 2FA B 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 307 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1pk9 C 1.9 BS02 2FA C 1 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 M64 S90 C91 G92 F159 V178 E179 M180 E181 D204 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 H4 G20 R24 R43 E75 R87 S90 S203 D204 I206 R217 2.4.2.1 0003824,0004731,0005737,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 P0ABP9 12937174 308 ATPHINAEMGDFADVVLMPGDPLRAKYIAETFLEDAREVNNVRGMLGFTGTYKGRKISVMGHGMGIPSCSIYTKELITDFGVKKIIRVGSCGAVLPHVKLRDVVIGMGACTDSKVNRIRFKDHDFAAIADFDMVRNAVDAAKALGIDARVGNLFSADLFYSPDGEMFDVMEKYGILGVEMEAAGIYGVAAEFGAKALTICTVSDHIRTHEQTTAAERQTTFNDMIKIALESVLLGDK 1z35 A 2.5 BS01 2FA A 1 M64 T90 C91 G92 F159 E179 M180 E181 M64 T90 C91 G92 F159 E179 M180 E181 0003824,0004731,0006139,0009116 15817485 300 ATPHNSAQVGDFAETVLMCGDPLRAKLIAETYLENPKLVNNVRGIQGYTGTYKGKPISVMGHGMGLPSICIYAEELYSTYKVKTIIRVGTCGAIDMDIHTRDIVIFTSAGTNSKINRIRFMDHDYPATASFDVVCALVDAAKELNIPAKVGKGFSTDLFYNPQTELAQLMNKFHFLAVEMESAGLFPIADLYGARAGCICTVSDHILHHEERQNSFQNMMKIALEAAIKL 2pkk A 1.93 BS01 2FA A 1 S8 D12 G48 V49 N52 F102 F116 M121 A146 Q172 Q173 D257 S16 D20 G56 V57 N60 F110 F124 M129 A154 Q180 Q181 D265 2.7.1.20 0000287,0004001,0005515,0005524,0005525,0005886,0006166,0016301,0016310,0016772,0032567,0044209 P9WID5 17597075 501 EDLYFQSHMTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVL 2zj0 A 2.42 BS01 2FA A 1 H69 T71 Q73 T74 D156 E218 T219 D252 H363 L407 G415 H416 M421 F425 H60 T62 Q64 T65 D147 E209 T210 D243 H354 L398 G406 H407 M412 F416 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H60 S83 S88 D147 E209 N234 K239 D243 N244 T248 H354 H407 S415 Q419 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 SLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 B 2.42 BS02 2FA B 1 H69 T71 Q73 D156 E218 T219 D252 H363 G415 H416 M421 F425 H59 T61 Q63 D146 E208 T209 D242 H353 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 C 2.42 BS01 2FA C 1 L68 H69 T71 T74 D156 E218 T219 D252 H363 L410 G415 H416 M421 F425 L58 H59 T61 T64 D146 E208 T209 D242 H353 L400 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 2zj0 D 2.42 BS02 2FA D 1 H69 T71 Q73 T74 D156 E218 T219 K248 D252 H363 L410 G415 H416 M421 F425 H59 T61 Q63 T64 D146 E208 T209 K238 D242 H353 L400 G405 H406 M411 F415 H69 S92 S97 D156 E218 N243 K248 D252 N253 T257 H363 H416 S424 Q428 H59 S82 S87 D146 E208 N233 K238 D242 N243 T247 H353 H406 S414 Q418 3.13.2.1 0004013,0005515,0005576,0005737,0005829,0005886,0006730,0009087,0009274,0016787,0033353,0035375,0035635,0044650,0046085,0070403,0071269 ic50=66uM P9WGV3 18815415 500 LTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY 4dan A 2.56 BS01 2FA A 1 S90 C91 G92 F159 V177 E178 M179 E180 S202 S89 C90 G91 F158 V176 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHS 4dan A 2.56 BS02 2FA B 1 H4 R43 H3 R42 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHS 4dan B 2.56 BS01 2FA A 1 H4 R43 H3 R42 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dan B 2.56 BS02 2FA B 1 S90 F159 E178 M179 E180 S202 S89 F158 E177 M178 E179 S201 H4 G20 R24 R43 E75 R87 S90 S202 D203 V205 R216 H3 G19 R23 R42 E74 R86 S89 S201 D202 V204 R215 2.4.2.1 0003824,0004731,0005829,0006139,0006152,0009116,0009164,0016757,0016763,0042278 O34925 22957058 301 SVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRGMYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRDVILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFYNDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQTTFHDMIDVALHSVS 4dc3 B 2.4 BS01 2FA B 1 N14 L16 D18 M134 T136 F169 G299 D302 N12 L14 D16 M132 T134 F167 G297 D300 R132 D302 R130 D300 0004001,0006166,0016301 23275171 401 DLSEGYVFGMGNPLLDIIVDADDFMYRKYNLKKDNIVLAEEKHMTIYDEIQKKKKLNYIAGGATLNTVKMIQWIIQKPFVCSYVGCIGADIQGKYIKNDCSALDLVTEFQIAEEPLMTGKVAVLVSEKLRSMVTYLGAACDLSLAHIEQPHVWSLVEKAQVYYIAGFVINTCYEGMLKIAKHSLENEKLFCFNLSAPFLSQFNTKEVDEMISYSNIVFGNESEAEAYGEVHGLLEDTVHATARYIADLPFADGKKRKRLVIITRGKNPLLYTDSSDSEIHQFMVEQFKDDQIIDTNGAGDAFAAGFIADYIRGKPMITSLHAAVKAAAYIICRSGFSLGSRDSY 4ube A 1.933 BS01 2FA A 1 S8 D12 G48 V49 N52 F102 F116 M121 A146 Q172 Q173 G254 D257 S16 D20 G56 V57 N60 F110 F124 M129 A154 Q180 Q181 G262 D265 2.7.1.20 0004001,0005524,0006166,0016301,0016310,0016772,0044209 P83736 401 EDLYFQSHMTIAVTGSIATDHLMRFPGRFSEQLLPEHLHKVSLSFLVDDLVMHRGGVAGNMAFAIGVLGGEVALVGAAGADFADYRDWLKARGVNCDHVLISETAHTARFTCTTDVDMAQIASFYPGAMSEARNIKLADVVSAIGKPELVIIGANDPEAMFLHTEECRKLGLAFAADPSQQLARLSGEEIRRLVNGAAYLFTNDYEWDLLLSKTGWSEADVMAQIDLRVTTLGPKGVDLVEPDGTTIHVGVVPETSQTDPTGVGDAFRAGFLTGRSAGLGLERSAQLGSLVAVLVLESTGTQEWQWDYEAAASRLAGAYGEHAAAEIVAVL