2q7m A 4.25 BS01 2CS A 1 V21 N23 G24 F25 A27 H28 V21 N23 G24 F25 A27 H28 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 502 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFF 2q7m A 4.25 BS02 2CS A 2 D62 A63 Y112 I113 K116 I119 L120 F123 D62 A63 Y112 I113 K116 I119 L120 F123 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 503 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFF 2q7m B 4.25 BS01 2CS A 2 V21 G24 F25 A27 H28 V21 G24 F25 A27 H28 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 -logKd/Ki=8.80, IC50=1.6nM IC50=2nM P20292 17600184 503 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIA 2q7m B 4.25 BS02 2CS C 1 D62 A63 K116 I119 L120 F123 D62 A63 K116 I119 L120 F123 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 -logKd/Ki=8.80, IC50=1.6nM IC50=2nM P20292 17600184 501 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIA 2q7m C 4.25 BS01 2CS A 1 D62 A63 I119 L120 D62 A63 I119 L120 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 -logKd/Ki=8.80, IC50=1.6nM IC50=2nM P20292 17600184 502 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIAT 2q7m C 4.25 BS02 2CS C 1 V21 N23 G24 F25 A27 V21 N23 G24 F25 A27 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 -logKd/Ki=8.80, IC50=1.6nM IC50=2nM P20292 17600184 501 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIAT 2q7m D 4.25 BS01 2CS D 1 V21 N23 G24 F25 A27 H28 V21 N23 G24 F25 A27 H28 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 504 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYI 2q7m D 4.25 BS02 2CS E 1 D62 K116 I119 L120 F123 D62 K116 I119 L120 F123 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 505 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYI 2q7m E 4.25 BS01 2CS E 1 V21 G24 F25 A27 H28 V21 G24 F25 A27 H28 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 505 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFG 2q7m E 4.25 BS02 2CS E 2 D62 A63 K116 I119 L120 F123 D62 A63 K116 I119 L120 F123 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 506 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFG 2q7m F 4.25 BS01 2CS D 1 D62 A63 K116 I119 L120 D62 A63 K116 I119 L120 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 504 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIAT 2q7m F 4.25 BS02 2CS E 2 V21 N23 G24 F25 A27 V21 N23 G24 F25 A27 ? 0002540,0002675,0004051,0004364,0004464,0004602,0005515,0005634,0005635,0005783,0005789,0006691,0008047,0016020,0019370,0019372,0019899,0031965,0042802,0044877,0050544,0070207,0071277,0098869 IC50=2nM P20292 17600184 506 MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIAT