4p3n A 2.6 BS01 2CR A 1 G387 H388 M411 C413 R442 Q460 F539 Y540 T560 D564 L567 H590 G66 H67 M90 C92 R121 Q139 F218 Y219 T239 D243 L246 H269 C413 R442 Q460 D462 H464 K543 H590 C92 R121 Q139 D141 H143 K222 H269 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P26639 25824639 800 DHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF 4p3n B 2.6 BS01 2CR B 1 G387 H388 M411 R442 Y540 D564 L567 H590 G66 H67 M90 R121 Y219 D243 L246 H269 C413 R442 Q460 D462 H464 K543 H590 C92 R121 Q139 D141 H143 K222 H269 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P26639 25824639 800 DHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF 4p3n C 2.6 BS01 2CR C 1 G387 H388 M411 R442 Y540 T560 D564 L567 H590 G66 H67 M90 R121 Y219 T239 D243 L246 H269 C413 R442 Q460 D462 H464 K543 H590 C92 R121 Q139 D141 H143 K222 H269 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P26639 25824639 800 DHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF 4p3n D 2.6 BS01 2CR D 1 G387 H388 H391 M411 R442 Y540 T560 D564 L567 H590 G66 H67 H70 M90 R121 Y219 T239 D243 L246 H269 C413 R442 Q460 D462 H464 K543 H590 C92 R121 Q139 D141 H143 K222 H269 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P26639 25824639 800 DHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFIRSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCLDFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERMIAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAEEEF 4p3o A 2.505 BS02 2CR A 1 G308 H309 M332 R363 Y462 T482 D486 H511 G67 H68 M91 R122 Y221 T241 D245 H270 C334 R363 Q381 D383 H385 K465 H511 C93 R122 Q140 D142 H144 K224 H270 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P0A8M3 25824639 702 RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE 4p3o B 2.505 BS02 2CR B 1 G308 H309 M332 C334 R363 Q381 Y462 D486 H511 G67 H68 M91 C93 R122 Q140 Y221 D245 H270 C334 R363 Q381 D383 H385 K465 H511 C93 R122 Q140 D142 H144 K224 H270 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 P0A8M3 25824639 702 RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE 4p3p A 2.1 BS02 2CR A 1 H309 M332 C334 R363 Q381 Y462 D486 H511 H68 M91 C93 R122 Q140 Y221 D245 H270 C334 R363 Q381 D383 H385 K465 H511 C93 R122 Q140 D142 H144 K224 H270 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 Ki=4nM P0A8M3 25824639 702 RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE 4p3p B 2.1 BS02 2CR B 1 G308 H309 Y313 M332 C334 R363 Q381 Y462 D486 H511 G67 H68 Y72 M91 C93 R122 Q140 Y221 D245 H270 C334 R363 Q381 D383 H385 K465 H511 C93 R122 Q140 D142 H144 K224 H270 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 Ki=4nM P0A8M3 25824639 702 RDHRKIGKQLDLYHMQEEAPGMVFWHNDGWTIFRELEVFVRSKLKEYQYQEVKGPFMMDRVLWEKTGHWDNYKDAMFTTSSENREYCIKPMNCPGHVQIFNQGLKSYRDLPLRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEEQIRDEVNGCIRLVYDMYSTFGFEKIVVKLSTRPEKRIGSDEMWDRAEADLAVALEENNIPFEYQLGEGAFYGPKIEFTLYDCLDRAWQCGTVQLDFSLPSRLSASYVGEDNERKVPVMIHRAILGSMERFIGILTEEFAGFFPTWLAPVQVVIMNITDSQSEYVNELTQKLSNAGIRVKADLRNEKIGFKIREHTLRRVPYMLVCGDKEVESGKVAVRTRRGKDLGSMDVNEVIEKLQQEIRSRSLKQLEE 5zy9 C 2.5 BS01 2CR C 1 G67 H68 M91 R122 F221 Y222 D246 L249 G67 H68 M91 R122 F221 Y222 D246 L249 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 G3FIN0 501 MDHRRLGVSEELFFFHSLSPGSGFWLPHGSAIYFKLLKFIREQYRARGYTEVITPNIFNMELWNISGHAKHYKENMFVFDVEGQEYALKPMNCPAASLMFDFRQRSYRELPIRYADCGVLHRNELSGALTGLTRVRRFQQDDAHIFCRDDQIKKEVLDFLSFMKYVYDVFGIEFNLELSTRPEKAMGELEQWERAESQLAEALDEFVGAGKWVVNPGDGAFYGPKIDIMITDALKRQHQCATVQLDFQLPIRFNLKYRTDDADNFKRPVIIHRAIYGSLERFVAVLVEHYAGKFPFWLSPRQVLIVTVGAAFVDYGYEVKDAMFRAGFDVDIDDTGKTLNKKIREGQMAHYNFILVVGAHEKETRSVNIRTRDNKVTGTKTLEEAIAMFKELEETKAADE 5zy9 D 2.5 BS01 2CR D 1 G67 H68 M91 R122 Y222 D246 H272 G67 H68 M91 R122 Y222 D246 H272 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 G3FIN0 501 MDHRRLGVSEELFFFHSLSPGSGFWLPHGSAIYFKLLKFIREQYRARGYTEVITPNIFNMELWNISGHAKHYKENMFVFDVEGQEYALKPMNCPAASLMFDFRQRSYRELPIRYADCGVLHRNELSGALTGLTRVRRFQQDDAHIFCRDDQIKKEVLDFLSFMKYVYDVFGIEFNLELSTRPEKAMGELEQWERAESQLAEALDEFVGAGKWVVNPGDGAFYGPKIDIMITDALKRQHQCATVQLDFQLPIRFNLKYRTDDADNFKRPVIIHRAIYGSLERFVAVLVEHYAGKFPFWLSPRQVLIVTVGAAFVDYGYEVKDAMFRAGFDVDIDDTGKTLNKKIREGQMAHYNFILVVGAHEKETRSVNIRTRDNKVTGTKTLEEAIAMFKELEETKAADE 5zy9 E 2.5 BS01 2CR E 1 G67 H68 M91 R122 Y222 D246 H272 G65 H66 M89 R120 Y220 D244 H270 6.1.1.3 0000166,0004812,0004829,0005524,0005737,0006418,0006435 G3FIN0 801 HRRLGVSEELFFFHSLSPGSGFWLPHGSAIYFKLLKFIREQYRARGYTEVITPNIFNMELWNISGHAKHYKENMFVFDVEGQEYALKPMNCPAASLMFDFRQRSYRELPIRYADCGVLHRNELSGALTGLTRVRRFQQDDAHIFCRDDQIKKEVLDFLSFMKYVYDVFGIEFNLELSTRPEKAMGELEQWERAESQLAEALDEFVGAGKWVVNPGDGAFYGPKIDIMITDALKRQHQCATVQLDFQLPIRFNLKYRTDDADNFKRPVIIHRAIYGSLERFVAVLVEHYAGKFPFWLSPRQVLIVTVGAAFVDYGYEVKDAMFRAGFDVDIDDTGKTLNKKIREGQMAHYNFILVVGAHEKETRSVNIRTRDNKVTGTKTLEEAIAMFKELEETKAADE