1pgq A 3.17 BS01 2AM A 1 N32 R33 T34 V74 K75 A79 F83 N32 R33 T34 V74 K75 A79 F83 S128 K183 H186 N187 E190 S128 K183 H186 N187 E190 1.1.1.44 0004616,0005737,0005829,0006098,0009051,0016491,0019521,0046177,0050661 P00349 7922042 500 AQADIALIGLAVMGQNLILNMNDHGFVVCAFNRTVSKVDDFLANEAKGTKVLGAHSLEEMVSKLKKPRRIILLVKAGQAVDNFIEKLVPLLDIGDIIIDGGNSEYRDTMRRCRDLKDKGILFVGSGVSGGEDGARYGPSLMPGGNKEAWPHIKAIFQGIAAKVGTGEPCCDWVGDDGAGHFVKMVHNGIEYGDMQLICEAYHLMKDVLGLGHKEMAKAFEEWNKTELDSFLIEITASILKFQDADGKHLLPKIRDSAGQKGTGKWTAISALEYGVPVTLIGEAVFARCLSSLKDERIQASKKLKGPQNIPFEGDKKSFLEDIRKALYASKIISYAQGFMLLRQAATEFGWTLNYGGIALMWRGGCIIRSVFLGKIKDAFDRNPGLQNLLLDDFFKSAVENCQDSWRRAISTGVQAGIPMPCFTTALSFYDGYRHAMLPANLIQAQRDYFGAHTYELLAKPGQFIHTNWTGHGG 1rgk A 1.87 BS01 2AM A 1 N36 Y38 H40 E58 G74 R77 H92 N36 Y38 H40 E58 G74 R77 H92 Y38 H40 E58 D76 R77 T91 H92 F100 Y38 H40 E58 D76 R77 T91 H92 F100 4.6.1.24 0001411,0003723,0004519,0004521,0004540,0008150,0016829,0030428,0046589 Kd=49.1uM -logKd/Ki=4.31, Kd=49.1uM P00651 1350642 105 ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNYQGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT 2ydd A 2.4 BS01 2AM A 1 Y168 H230 T232 F235 H309 T311 P320 V321 Y6 H62 T64 F67 H141 T143 P152 V153 3.1.4.37 0004113,0009214,0016020 P16330 22393399 1379 DFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFIEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 2yq9 A 1.9 BS01 2AM A 1 Y168 T232 F235 H309 T311 P320 A321 T323 Y7 T67 F70 H144 T146 P155 A156 T158 3.1.4.37 0004113,0009214,0016020 P16330 23831225 1379 KDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSRAHVTLGCAADVQPAQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 3ahw A 1.03 BS01 2AM A 1 Y39 H41 E62 G82 R85 H101 F110 Y39 H41 E62 G82 R85 H101 F110 Y39 H41 E62 R85 H101 F110 Y39 H41 E62 R85 H101 F110 4.6.1.20 0003723,0004519,0004521,0004540,0016829,0033899,0046872 P00654 20858208 121 CDIPQSTNCGGNVYSNDDINTAIQGALDDVANGDRPDNYPHQYYDEASEDITLCCGSGPWSEFPLVYNGPYYSSRDNYVSPGPDRVIYQTNTGEFCATVTHTGAASYDGFTQCS 3ocx A 1.901 BS01 2AM A 1 D64 N66 F86 W91 N125 Y221 D55 N57 F77 W82 N116 Y212 3.1.3.2 0009279 P26093 20934434 263 EHANMQLQQQAVLGLNWMQDSGEYKALAYQAYNAAKVAFDHAKVAKGKKKAVVADLNETMLDNSPYAGWQVQNNKPFDGKDWTRWVDARQSRAVPGAVEFNNYVNSHNGKVFYVTNRKDSTEKSGTIDDMKRLGFNGVEESAFYLKKDKSAKAARFAEIEKQGYEIVLYVGDNLDDFGNTVYGKLNADRRAFVDQNQGKFGKTFIMLPNANYGGWEGGLAEGYFKKDTQGQIKARLDAVQAWDGKL 4qak A 2.025 BS01 2AM B 1 R86 D131 R83 D126 3.1.4.58 0004113,0008081,0008664,0016787 P37025 201 PQRLFFAIDLPAEIREQIIHWRATHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFQSPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ 4qak B 2.025 BS01 2AM B 1 F8 H43 T45 F48 H125 T127 R130 F6 H41 T43 F46 H123 T125 R128 3.1.4.58 0004113,0008081,0008664,0016787 P37025 201 EPQRLFFAIDLPAEIREQIIHWRATHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFQSNRPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ 4wcc A 2.7 BS01 2AM A 1 F235 H309 T311 P320 F67 H136 T138 P147 3.1.4.37 0004113,0009214,0016020 P16330 26563764 401 KDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFEKLELVSYFGKRGPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLSEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 4wda A 1.85 BS01 2AM A 1 Y168 H230 T232 F235 H309 T311 P320 Y8 H67 T69 F72 H142 T144 P153 3.1.4.37 0004113,0009214,0016020 P16330 26563764 401 EKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISGKEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 4wdb A 1.6 BS01 2AM A 1 Y168 H230 T232 F235 H309 T311 P320 Y8 H64 T66 F69 H143 T145 P154 3.1.4.37 0004113,0009214,0016020 P16330 26563764 401 EKDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFIEKLELVSYFGKRPPGVLHCTTKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDLDKPSASEGLPPGSQAHVTLGCAADVQPVQTGLDLLDILQQVKGGSQGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 4wfr A 2.0 BS01 2AM A 1 Y168 H230 F235 H309 T311 P320 V321 Y7 H64 F69 H139 T141 P150 V151 3.1.4.37 0004113,0009214,0016020 P16330 26563764 401 KDFLPLYFGWFLTKKSSETLRKAGQVFLEELGNHKAFKKELRHFISEKLELVSYFGKRPPGVLHCATKFCDYGKAAGAEEYAQQEVVKRSYGKAFKLSISALFVTPKTAGAQVVLTDQELQLWPSDSASEGLPPGSRAHVTLGCAADVQPVQTGLDLLDILQQVKGEAVGELPRGKLYSLGKGRWMLSLTKKMEVKAIFTGYYG 4yaf A 1.91 BS03 2AM A 1 C566 S596 R597 K602 Y604 Q606 M636 C497 S527 R528 K533 Y535 Q537 M567 Y456 S457 C630 D675 W677 Y392 S393 C561 D606 W608 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 APPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yaf B 1.91 BS03 2AM B 1 C566 S596 R597 K602 Y604 Q606 M636 C493 S523 R524 K529 Y531 Q533 M563 Y456 S457 C630 D675 W677 Y387 S388 C557 D602 W604 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 KESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yal A 1.88 BS03 2AM A 1 C566 S596 R597 K602 Y604 Q606 M636 C496 S526 R527 K532 Y534 Q536 M566 Y456 S457 C630 D675 W677 Y391 S392 C560 D605 W607 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yal B 1.88 BS03 2AM B 1 C566 S596 R597 K602 Y604 Q606 M636 C496 S526 R527 K532 Y534 Q536 M566 Y456 S457 C630 D675 W677 Y390 S391 C560 D605 W607 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yao A 2.5 BS03 2AM A 1 G534 C566 S596 R597 K602 Y604 Q606 M636 G458 C490 S520 R521 K526 Y528 Q530 M560 Y456 S457 C630 D675 W677 Y385 S386 C554 D599 W601 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEARQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPARALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yao B 2.5 BS03 2AM B 1 C566 S596 R597 K602 Y604 Q606 M636 C484 S514 R515 K520 Y522 Q524 M554 Y456 S457 C630 D675 W677 Y378 S379 C548 D593 W595 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEAIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yau A 2.2 BS03 2AM A 1 G534 C566 S596 R597 K602 Y604 Q606 M636 G465 C497 S527 R528 K533 Y535 Q537 M567 Y456 S457 C630 D675 W677 Y391 S392 C561 D606 W608 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYNGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATSSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yau B 2.2 BS03 2AM B 1 C566 S596 R597 K602 Y604 Q606 M636 C490 S520 R521 K526 Y528 Q530 M560 Y456 S457 C630 D675 W677 Y384 S385 C554 D599 W601 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYNGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yaw A 2.0 BS03 2AM A 1 G534 C566 S596 R597 K602 Y604 Q606 M636 G468 C500 S530 R531 K536 Y538 Q540 M570 Y456 S457 C630 D675 W677 Y394 S395 C564 D609 W611 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 TTAPPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATSSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 4yaw B 2.0 BS03 2AM B 1 G534 C566 S596 R597 K602 Y604 Q606 M636 G457 C489 S519 R520 K525 Y527 Q529 M559 Y456 S457 C630 D675 W677 Y383 S384 C553 D598 W600 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 27189945 703 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEAIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGDARNMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 5dw8 A 2.4 BS02 2AM A 1 D86 G87 G182 A184 R203 D77 G78 G173 A175 R194 302 MALYGFAQGLIQEAGIRIKQLMEQNNDLVTNVDKATEDFIFDTILETYPNHQVLGEEGHGHDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQR 5dw8 B 2.4 BS03 2AM B 1 D86 G87 T88 A184 R203 D75 G76 T77 A173 R192 303 SMALYGFAQGLIQEAGIRIKQLMEQNVTNVDKATEDFIFDTILETYPNHQVLGEEGHGHDIDTSKGTVWVVDPIDGTLNFVHQQENFAISIGIYIDGKPYAGFVYDVMADVLYHAKVGEGAYRGSQPLKPLNDSNLRQSIIGINPNWLTKPILGEIFKEIVNDSRSARAYGSAALEIVSVATGNLEAYMTPRLQPWDFAGGLVILYEVNGQASNLLGEPLTISGPNSILVGNRGLHQEISNDYLEPHHDALIQLHEQRF 5ldm A 2.46 BS01 2AM A 1 F8 H43 T45 F48 H125 T127 R130 F6 H41 T43 F46 H123 T125 R128 3.1.4.58 0004113,0005524,0008081,0008664,0016787,0016874 Ka=7210M^-1 -logKd/Ki=3.86, Kd=139uM A0A140NFI1 28141848 201 EPQRLFFAIDLPAEIREQIIHWRAKHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFQSNRPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ 5ldm B 2.46 BS01 2AM A 1 R86 D131 R85 D126 3.1.4.58 0004113,0005524,0008081,0008664,0016787,0016874 Ka=7210M^-1 A0A140NFI1 28141848 201 SEPQRLFFAIDLPAEIREQIIHWRAKHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ 5ldm B 2.46 BS02 2AM B 1 H43 F48 H125 T127 R130 H42 F47 H120 T122 R125 3.1.4.58 0004113,0005524,0008081,0008664,0016787,0016874 Ka=7210M^-1 A0A140NFI1 28141848 201 SEPQRLFFAIDLPAEIREQIIHWRAKHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKALSLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFPFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ 5uri A 2.7 BS03 2AM A 1 G534 C566 S596 R597 Y604 Q606 G467 C499 S529 R530 Y537 Q539 S457 C630 D675 W677 S394 C563 D607 W609 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 29308883 703 PPVKESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEATESSIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGAANMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 5uri B 2.7 BS03 2AM B 1 G534 C566 S596 R597 K602 Y604 Q606 M636 G459 C491 S521 R522 K527 Y529 Q531 M560 S457 C630 D675 W677 S386 C555 D599 W601 1.6.2.4 0003420,0003958,0004128,0005737,0005783,0005789,0005829,0007584,0008941,0009055,0009410,0009437,0009725,0009812,0010181,0016020,0016491,0016787,0019395,0019899,0022900,0032332,0043066,0043231,0043602,0045542,0045880,0046210,0047726,0050660,0050661,0070988,0071371,0071372,0071375,0071548,0090031,0090181,0090346 P00388 29308883 703 SSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDKSLVVFCMATYGEGDPTDNAQDFYDWLQETDVDLTGVKFAVFGLGNKTYEHFNAMGKYVDQRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWPAVCEFFGVEASIRQYELVVHEDMDVAKVYTGEMGRLKSYENQKPPFDAKNPFLAAVTANRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQIGEILGADLDVIMSLNNLDEESNKKHPFPCPTTYRTALTYYLDITNPPRTNVLYELAQYASEPSEQEHLHKMASSSGEGKELYLSWVVEARRHILAILQDYPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVAVEYEAKSGRVNKGVATSWLRAKEPAGRALVPMFVRKSQFRLPFKSTTPVIMVGPGTGIAPFMGFIQERAWLREQGKEVGETLLYYGCRRSDEDYLYREELARFHKDGALTQLNVAFSREQAHKVYVQHLLKRDREHLWKLIHEGGAHIYVCGAANMAKDVQNTFYDIVAEFGPMEHTQAVDYVKKLMTKGRYSLDVWS 6rnt A 1.8 BS01 2AM A 1 N36 Y38 H40 E58 G74 R77 H92 N36 Y38 H40 E58 G74 R77 H92 Y38 H40 E58 D76 R77 T91 H92 F100 Y38 H40 E58 D76 R77 T91 H92 F100 4.6.1.24 0001411,0003723,0004519,0004521,0004540,0008150,0016829,0030428,0046589 Kd=4.3mM -logKd/Ki=2.37, Kd=4.3mM P00651 1651320 105 ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNYEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT 7rnt A 1.9 BS01 2AM A 1 Y38 H40 E58 G74 R77 H92 N98 F100 Y38 H40 E58 G74 R77 H92 N98 F100 Y38 H40 E58 D76 R77 T91 H92 F100 Y38 H40 E58 D76 R77 T91 H92 F100 4.6.1.24 0001411,0003723,0004519,0004521,0004540,0008150,0016829,0030428,0046589 P00651 1915364 105 ACDYTCGSNCYSSSDVSTAQAAGYKLHEDGETVGSNSYPHKYNNWEGFDFSVSSPYYEWPILSSGDVYSGGSPGADRVVFNENNQLAGVITHTGASGNNFVECT