4bud A 2.5 BS02 29F A 1 H1031 G1032 S1033 F1035 Y1050 Y1060 A1062 K1067 S1068 Y1071 H80 G81 S82 F84 Y99 Y109 A111 K116 S117 Y120 2.4.2.-,2.4.2.30 0003950 ic50=5nM IC50=8.7nM, EC50=1500nM Q9H2K2 24130191 2165 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 4bud C 2.5 BS02 29F C 1 G1032 S1033 F1035 H1048 Y1050 Y1060 K1067 S1068 Y1071 E1138 G81 S82 F84 H97 Y99 Y109 K116 S117 Y120 E186 2.4.2.-,2.4.2.30 0003950 ic50=5nM IC50=8.7nM, EC50=1500nM Q9H2K2 24130191 2165 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5aku A 1.8 BS01 29F A 1 H1031 G1032 F1035 Y1050 Y1060 F1061 A1062 S1068 Y1071 H80 G81 F84 Y99 Y109 F110 A111 S117 Y120 2.4.2.-,2.4.2.30 0003950 ic50=150nM -logKd/Ki=6.82, IC50=150nM IC50=8.7nM, EC50=1500nM Q9H2K2 26183543 2164 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE 5aku B 1.8 BS01 29F B 1 H1031 G1032 Y1050 Y1060 F1061 A1062 S1068 Y1071 H80 G81 Y99 Y109 F110 A111 S117 Y120 2.4.2.-,2.4.2.30 0003950 ic50=150nM IC50=8.7nM, EC50=1500nM Q9H2K2 26183543 2164 GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVCNKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQFSAMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE