4mg9 A 2.0 BS02 27K A 1 A350 E353 L387 L391 A46 E49 L83 L87 ? -logKd/Ki=5.68, Kd=2.11uM IC50=1420nM P03372 25260197 601 SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 4mg9 B 2.0 BS02 27K B 1 E353 L387 M421 E47 L81 M115 ? IC50=1420nM P03372 25260197 601 NSLALSLTADQMVSALLDAEPPILYSEYDPFSEASMMGLLTNLADRELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR 5z9e A 1.8 BS01 27K A 1 N46 I78 N31 I63 5.6.2.2 0003677,0003918,0005524,0006265 -logKd/Ki=3.48, IC50=0.33mM P0AES6 30429968 304 LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHY 5z9e B 1.8 BS01 27K B 1 N46 E50 I78 V120 V167 N31 E35 I63 V87 V134 5.6.2.2 0003677,0003918,0005524,0006265 P0AES6 30429968 302 LDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEG 7dts a 2.63 BS02 27K a 1 A388 C435 E436 Y437 L489 A499 D500 A356 C403 E404 Y405 L457 A467 D468 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 802 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dts b 2.63 BS03 27K b 1 I377 A388 L434 C435 E436 Y437 L489 A499 D500 I348 A359 L405 C406 E407 Y408 L460 A470 D471 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 802 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT