1qa0 A 1.8 BS02 270 A 1 D177 S178 C179 G200 G202 D171 S172 C173 G194 G196 H46 D90 Q180 G181 D182 S183 G184 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 P00760 10417407 300 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN 2fpz A 2.0 BS01 270 A 1 D189 S190 C191 Q192 G216 G219 D188 S189 C190 Q191 G215 G217 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 Ki=110uM -logKd/Ki=3.96, Ki=110uM P20231 16681368 1000 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fpz B 2.0 BS01 270 B 1 D189 S190 C191 Q192 G216 G219 D188 S189 C190 Q191 G215 G217 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 Ki=110uM P20231 16681368 1001 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fpz C 2.0 BS01 270 C 1 D189 S190 C191 Q192 G216 G219 D188 S189 C190 Q191 G215 G217 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 Ki=110uM P20231 16681368 1002 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fpz D 2.0 BS01 270 D 1 D189 S190 C191 W215 G216 G219 D188 S189 C190 W214 G215 G217 H57 D102 Q192 G193 D194 S195 G196 H44 D91 Q191 G192 D193 S194 G195 3.4.21.59 0004252,0005515,0005576,0005615,0006508,0008236,0062023 Ki=110uM P20231 16681368 1003 IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVKVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPK 2fx6 A 1.57 BS02 270 A 1 D189 S190 C191 Q192 G216 D171 S172 C173 Q174 G194 H57 D102 Q192 G193 D194 S195 G196 H40 D84 Q174 G175 D176 S177 G178 3.4.21.4 0004175,0004252,0005515,0005576,0005615,0006508,0007586,0008236,0046872,0097180,0097655 Ki=200uM -logKd/Ki=3.70, Ki=200uM P00760 16681368 246 IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIKQTIASN