1wdy A 1.8 BS01 25A A 1 E55 W60 Q68 K89 Y124 F126 E131 Y135 R155 E35 W40 Q48 K69 Y104 F106 E111 Y115 R135 3.1.26.- -logKd/Ki=7.89, IC50=13nM IC50=20nM, EC50=0.210000nM Q05823 15385955 1001 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFLLAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV 3pwk A 1.5 BS01 25A A 1 G9 T11 G12 A13 A36 S37 R39 S40 T57 A72 T76 G161 G8 T10 G11 A12 A35 S36 R38 S39 T56 A71 T75 G160 0004073,0008652,0009086,0009088,0009089,0009097,0016620,0046983,0050661,0051287 22039970 367 GYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQDITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQNPDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGAGMGAILETQRELREVLNDGVKPCDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAFPGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTAELKFELK 3pwk B 1.5 BS01 25A B 1 G9 T11 G12 A13 A36 S37 R39 S40 T57 A72 T76 G161 M162 G8 T10 G11 A12 A35 S36 R38 S39 T56 A71 T75 G160 M161 0004073,0008652,0009086,0009088,0009089,0009097,0016620,0046983,0050661,0051287 22039970 367 GYTVAVVGATGAVGAQMIKMLEESTLPIDKIRYLASARSAGKSLKFKDQDITIEETTETAFEGVDIALFSAGSSTSAKYAPYAVKAGVVVVDNTSYFRQNPDVPLVVPEVNAHALDAHNGIIACPNCSTIQMMVALEPVRQKWGLDRIIVSTYQAVSGAGMGAILETQRELREVLNDGVKPCDLHAEILPSGGDKKHYPIAFNALPQIDVFTDNDYTYEEMKMTKETKKIMEDDSIAVSATCVRIPVLSAHSESVYIETKEVAPIEEVKAAIAAFPGAVLEDDVAHQIYPQAINAVGSRDTFVGRIRKDLDAEKGIHMWVVSDNLLKGAAWNSVQIAETLHERGLVRPTAELKFELKLE 4g8l A 2.8 BS01 25A A 1 E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155 E40 E42 G43 W45 Q53 K74 Y109 F111 E116 Y120 R140 3.1.26.- -logKd/Ki=8.00, Kd=10nM IC50=20nM, EC50=0.210000nM Q05823 23084743 401 SSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTCGDLVMTARRNYDHSLVKVLLSHGA 4g8l A 2.8 BS02 25A B 1 M306 R309 R310 Y312 M288 R291 R292 Y294 3.1.26.- -logKd/Ki=8.00, Kd=10nM IC50=20nM, EC50=0.210000nM Q05823 23084743 401 SSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTCGDLVMTARRNYDHSLVKVLLSHGA 4g8l B 2.8 BS01 25A A 1 M306 R309 R310 Y312 M275 R278 R279 Y281 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTGDLVMTARRNYDHSLVKVLLSHGA 4g8l B 2.8 BS02 25A B 1 E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155 E35 E37 G38 W40 Q48 K69 Y104 F106 E111 Y115 R135 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTGDLVMTARRNYDHSLVKVLLSHGA 4g8l C 2.8 BS01 25A C 1 E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155 E41 E43 G44 W46 Q54 K75 Y110 F112 E117 Y121 R141 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDLVMTARRNYDHSLVKVLLSHGA 4g8l C 2.8 BS02 25A D 1 M306 R309 R310 Y312 M281 R284 R285 Y287 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDLVMTARRNYDHSLVKVLLSHGA 4g8l D 2.8 BS01 25A C 1 M306 R309 R310 Y312 M275 R278 R279 Y281 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTGDLVMTARRNYDHSLVKVLLSHGA 4g8l D 2.8 BS02 25A D 1 E55 E57 G58 W60 N65 Q68 K89 Y124 F126 E131 Y135 R155 E35 E37 G38 W40 N45 Q48 K69 Y104 F106 E111 Y115 R135 3.1.26.- IC50=20nM, EC50=0.210000nM Q05823 23084743 401 AAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTGDLVMTARRNYDHSLVKVLLSHGA 6m11 a 2.46 BS01 25A a 1 W56 W58 S63 Q66 K87 N89 N122 F124 E129 Y133 R153 W35 W37 S42 Q45 K66 N68 N101 F103 E108 Y112 R132 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 32830849 1000 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKAGDFRPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 6m11 a 2.46 BS03 25A b 1 R307 R353 R286 R330 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 32830849 801 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHKAGDFRPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 6m11 b 2.46 BS01 25A a 1 R307 Y310 R353 R285 Y288 R328 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 32830849 1000 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHAGEDFPPANWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTESTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 6m11 b 2.46 BS02 25A b 1 W58 K87 N122 F124 E129 R153 W36 K65 N100 F102 E107 R131 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 32830849 801 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHAGEDFPPANWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTESTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dsy a 2.651 BS01 25A a 1 W56 W58 S63 Q66 K87 N89 N122 F124 E129 Y133 R153 W35 W37 S42 Q45 K66 N68 N101 F103 E108 Y112 R132 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dsy a 2.651 BS03 25A b 1 R307 R308 Y310 R353 R286 R287 Y289 R321 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dsy b 2.651 BS01 25A a 1 R307 R308 Y310 R353 R285 R286 Y288 R320 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dsy b 2.651 BS02 25A b 1 W56 W58 S63 K87 N89 N122 F124 E129 Y133 W34 W36 S41 K65 N67 N100 F102 E107 Y111 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dts a 2.63 BS01 25A a 1 W56 W58 Q66 K87 N89 N122 F124 E129 Y133 R153 W35 W37 Q45 K66 N68 N101 F103 E108 Y112 R132 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dts a 2.63 BS03 25A b 1 R307 R308 Y310 R353 F362 R286 R287 Y289 R321 F330 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 SLEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHNWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPSELSTSFAQWTTKIDSFVMEEMNALYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dts b 2.63 BS01 25A a 1 R307 R308 Y310 R353 R285 R286 Y288 R324 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT 7dts b 2.63 BS02 25A b 1 W56 W58 Q66 K87 N89 N122 F124 E129 Y133 K164 W34 W36 Q44 K65 N67 N100 F102 E107 Y111 K142 ? 0004540,0004672,0005524,0006397,0006468,0046872 A5H025 801 LEEMLTQAVQEADIEQVRQLLERGADANFQEEEWGWSPLHSAVQMDSEDLVALLLKHGADPCLRKRNGATPFIIAGITGNVRLLQLLLPNVEDVNECDVNGFTAFMEAAVYGRVEALRFLYENGADVNMHRKTKQDQERIRKGGATALMDAAEKGHVGVVTILLHAMKAEVDARDNMGRNALVYALLNPDDGKAKAITRLLLDHGADVNVRGEGSKTPLILAVERKNLDLVQMLLEQEQIEVNDTDREGKTALLLAVELRLEEIAKLLCHRGASTNCGDLVAIARRNYDSDLVKFLRLHPPAENWKPQSSRWGEALKHLHRIWRPMIGKLKIFIDEEYKIADTAEGGIYLGLYEDQEVAVKRFSEGSTRGQQEVSCLQSSRANDNVVTFYGSESDGSCLHVCLALCEYTLQEHLANHRGDAVPNEEDESARNILSSLFKAIGELHRSGYSHQDLQPQNILIDSKNGTFLADFDKSIKWAEDPQKIKRDLEALGLLVLYVVKKGDISFETLKNQSFEEVIQGSPDEETRDLIHHLFHPGDNVEDRLSSLLAHPFFWSWESRYRTLRDVGNESDIKTRNQNSRILQLLQPGTLSTSFAQWTTKIDSFVMEEMNAYNLYQDTLGDLLKFIRNLGEHINEQKNKKMKSIIGEPSQYFQEKFPDLVMYVYTKLQNTEYMKHFPKT