4mdt A 2.59 BS02 24G A 1 L62 K143 I159 D160 F161 F192 M195 I198 G210 S211 K239 K262 H265 L62 K143 I159 D160 F161 F192 M195 I198 G210 S211 K239 K262 H265 0008759,0009245 -logKd/Ki=5.00, Kd<10uM 24108127 402 MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNSAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP 4mdt B 2.59 BS02 24G B 1 L18 I159 D160 F161 F192 F194 V217 K239 K262 H265 L18 I159 D160 F161 F192 F194 V217 K239 K262 H265 0008759,0009245 24108127 402 MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNSAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP 4mdt C 2.59 BS02 24G C 1 F161 F192 I198 G210 S211 F212 K239 K262 H265 F161 F191 I197 G209 S210 F211 K238 K261 H264 0008759,0009245 24108127 402 MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNSAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP 4mdt D 2.59 BS02 24G D 1 L18 K143 I159 D160 F161 F192 F194 M195 I198 G210 S211 A215 K239 K262 G264 H265 L15 K140 I156 D157 F158 F189 F191 M192 I195 G207 S208 A212 K236 K259 G261 H262 0008759,0009245 24108127 402 QRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNSAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLA 4oze A 1.61 BS05 24G A 1 H19 H58 R137 G153 E154 F155 F180 C181 E185 G195 G198 K227 R250 G252 H253 H18 H57 R136 G152 E153 F154 F179 C180 E184 G194 G197 K226 R249 G251 H252 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 O67648 306 GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFCFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQ 4oze B 1.61 BS04 24G B 1 H19 H58 R137 G153 E154 F155 F180 C181 E185 I186 K227 R250 G252 H253 H18 H57 R136 G152 E153 F154 F179 C180 E184 I185 K226 R249 G251 H252 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 O67648 305 GLEKTVKEKLSFEGVGIHTGEYSKLIIHPEKEGTGIRFFKNGVYIPARHEFVVHTNHSTDLGFKGQRIKTVEHILSVLHLLEITNVTIEVIGNEIPILDGSGWEFYEAIRKNILNQNREIDYFVVEEPIIVEDEGRLIKAEPSDTLEVTYEGEFKNFLGRQKFTFVEGNEEEIVLARTFCFDWEIEHIKKVGLGKGGSLKNTLVLGKDKVYNPEGLRYENEPVRHKVFDLIGDLYLLGSPVKGKFYSFRGGHSLNVKLVKELAKKQK 8v24 B 3.6 BS01 24G B 1 L18 L62 F161 F192 F194 C207 S211 A215 V217 K239 K262 S263 L18 L62 F161 F192 F194 C207 S211 A215 V217 K239 K262 S263 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 P0A726 38635633 401 MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPS 8v24 D 3.6 BS01 24G D 1 L62 F161 F192 F194 I198 C207 G210 S211 A215 V217 K239 K262 L62 F161 F192 F194 I198 C207 G210 S211 A215 V217 K239 K262 3.5.1.108 0006796,0008759,0009245,0016787,0019637,0046872,0103117,1901135 P0A726 38635633 401 MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDTMLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGIDELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSADAFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKMLDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAPSA