2f89 F 2.6 BS04 210 F 1 D103 R112 K200 D243 K257 D96 R105 K193 D236 K250 2.5.1.1,2.5.1.10 0004659,0008299,0016765 -logKd/Ki=6.48, Ki=331nM IC50=200nM, Ki=55.9nM P14324 16892359 9001 DVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK 3sdr A 1.86 BS03 210 A 1 D566 R710 D713 D530 R674 D677 R529 L538 A559 D566 D570 S666 I667 G668 R710 D713 T717 F790 D794 F796 R493 L502 A523 D530 D534 S630 I631 G632 R674 D677 T681 F748 D752 F754 4.2.3.38 0000287,0003824,0005737,0008299,0010333,0016102,0016829,0046872,0052681 O81086 22153510 822 WGYDLVHSLKSPYIDSSYRERAEVLVSEIKAMLNPAITGDGESMITPSAYDTAWVARVPAIDGSARPQFPQTVDWILKNQLKDGSWGIQSHFLLSDRLLATLSCVLVLLKWNVGDLQVEQGIEFIKSNLELVKDETDQDSLVTDFEIIFPSLLREAQSLRLGLPYDLPYIHLLQTKRQERLAKLSREEIYAVPSPLLYSLEGIQDIVEWERIMEVQSQDGSFLSSPASTACVFMHTGDAKCLEFLNSVMIKFGNFVPCLYPVDLLERLLIVDNIVRLGIYRHFEKEIKEALDYVYRHWNERGIGWGRLNPIADLETTALGFRLLRLHRYNVSPAIFDNFKDAKFICSTGQFNKDVASMLNLYRASQLAFPGENILDEAKSFATKYLREALEKSETSSAWNNKQNLSQEIKYALKTSWHASVPRVEAKRYCQVYRPDYARIAKCVYKLPYVNNEKFLELGKLDFNIIQSIHQEEMKNVTSWFRDSGLPLFTFARERPLEFYFLVAAGTYEPQYAKCRFLFTKVACLQTVLDDMYDTYGTLDELKLFTEAVRRWDLSFTENLPDYMKLCYQIYYDIVHEVAWEAEKEQGRELVSFFRKGWEDYLLGYYEEAEWLAAEYVPTLDEYIKNGITSIGQRILLLSGVLIMDGQLLSQEALEKVDYPGRRVLTELNSLISRLADDTKTYKALASSIECYMKDHPECTEEEALDHIYSILEPAVKELTREFLKPDDVPFACKKMLFEETRVTMVIFKDGDGFGVSKLEVKDHIKECLIEPLPL 4kpj A 1.95 BS01 210 A 1 D103 R112 K200 D243 K257 D91 R100 K188 D231 K245 K57 F98 D103 D107 R112 D174 K200 F239 D243 D244 K45 F86 D91 D95 R100 D162 K188 F227 D231 D232 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=200nM, Ki=55.9nM P14324 901 VYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFASFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4nkf A 2.0 BS03 210 A 1 D103 R112 K200 D243 K257 D92 R101 K189 D232 K246 K57 F98 D103 D107 R112 D174 K200 A239 D243 D244 K46 F87 D92 D96 R101 D163 K189 A228 D232 D233 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=200nM, Ki=55.9nM P14324 404 DVYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 4ogu A 2.1 BS04 210 A 1 D103 R112 K200 Q240 D243 K257 D92 R101 K189 Q229 D232 K246 K57 F98 D103 D107 R112 D174 K200 A239 D243 D244 K46 F87 D92 D96 R101 D163 K189 A228 D232 D233 2.5.1.1,2.5.1.10 0004659,0008299,0016765 IC50=200nM, Ki=55.9nM P14324 405 DVYAQEKQDFVQHFSQIVRVLTEHPEIGDAIARLKEVLEYNTIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFAQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYK 5erm A 2.303 BS01 210 A 1 D92 R188 N232 K239 E240 R325 Y326 D91 R145 N189 K196 E197 R282 Y283 A69 F89 F165 E194 W319 A68 F88 F126 E151 W276 2.5.1.29,4.2.3.43 A2PZA5 26734760 401 EFKYSEVVEPSTYYTEGLCEGIDVRKSKFTTLEDRGAIRAHEDWNKHIGPCREYRGTLGPRFSFISVAVPECIPERLEVISYANEFAFLHDDVTDGKKRIQSQLFLEMLAIDPECAKTTMKSWARFVEVGSSTRFVELAKYIPYRIMDVGEMFWFGLVTFGLGLHIPDHELELCRELMANAWIAVGLQNDIWSWPKERDAATLHGKDHVVNAIWVLMQEHQTDVDGAMQICRKLIVEYVAKYLEVIEATKNDESISLDLRKYLDAMLYSISGNVVWSLECPRYNPDVSFNKTQLEWMRQGL 5erm B 2.303 BS04 210 B 1 D92 R188 N232 S236 K239 E240 R325 Y326 D91 R158 N202 S206 K209 E210 R295 Y296 A69 F89 F165 E194 W319 A68 F88 F137 E164 W289 2.5.1.29,4.2.3.43 A2PZA5 26734760 704 EFKYSEVVEPSTYYTEGLCEGIDVRKSKFTTLEDRGAIRAHEDWNKHIGPCREYRGTLGPRFSFISVAVPECIPERLEVISYANEFAFLHDDVTDHVGHDTDIRRAGKKRIQSQLFLEMLAIDPECAKTTMKSWARFVEVGSSRETRFVELAKYIPYRIMDVGEMFWFGLVTFGLGLHIPDHELELCRELMANAWIAVGLQNDIWSWPKERDAATLHGKDHVVNAIWVLMQEHQTDVDGAMQICRKLIVEYVAKYLEVIEATKNDESISLDLRKYLDAMLYSISGNVVWSLECPRYNPDVSFNKTQLEWMRQGL 5ero A 2.55 BS03 210 A 1 D474 R483 Q602 D605 K619 K629 D62 R71 Q184 D187 K201 K211 2.5.1.29,4.2.3.43 0004659,0008299 A2PZA5 26734760 804 DHIFFEKAVLEAPYDYIASMPSKGVRDQFIDALNDWLRVPDVKVGKIKDAVRVLHNSSLLLDDFQDNSPLRRGKPSTHNIFGSAQTVNTATYSIIKAIGQIMEFSAGEVQEVMNSIMILFQGQAMDLFWTYNGHVPSEEEYYRMIDQKTGQLFSIATSLLLNAARTKIQSCLHRLTRLLGRCFQIRDDYQNLVSADYTKQKGFCEDLDEGKWSLALIHMIHKQRSHMALLNVLSTGRKHGGMTLEQKQFVLDIIEEEKSLDYTRSVMMDLHVQLRAEIGRIEILLDSPNPAMRLLLELLRV 5ero B 2.55 BS03 210 B 1 D474 R483 K561 Q602 D605 K619 K629 D61 R70 K145 Q186 D189 K203 K213 2.5.1.29,4.2.3.43 0004659,0008299 A2PZA5 26734760 804 HIFFEKAVLEAPYDYIASMPSKGVRDQFIDALNDWLRVPDVKVGKIKDAVRVLHNSSLLLDDFQDNSPLRRGKPSTHNIFGSAQTVNTATYSIIKAIGQIMEFSAGEEVMNSIMILFQGQAMDLFWTYNGHVPSEEEYYRMIDQKTGQLFSIATSLLLNAADNEIPRTKIQSCLHRLTRLLGRCFQIRDDYQNLVSADYTKQKGFCEDLDEGKWSLALIHMIHKQRSHMALLNVLSTGRKHGGMTLEQKQFVLDIIEEEKSLDYTRSVMMDLHVQLRAEIGRIEILLDSPNPAMRLLLEL 5ero C 2.55 BS04 210 C 1 D474 R483 K561 Q602 D605 K619 K629 D60 R69 K147 Q188 D191 K205 K215 2.5.1.29,4.2.3.43 0004659,0008299 A2PZA5 26734760 804 IFFEKAVLEAPYDYIASMPSKGVRDQFIDALNDWLRVPDVKVGKIKDAVRVLHNSSLLLDDFQDNSPLRRGKPSTHNIFGSAQTVNTATYSIIKAIGQIMEFSAGESVQEVMNSIMILFQGQAMDLFWTYNGHVPSEEEYYRMIDQKTGQLFSIATSLLLNAADNEIPRTKIQSCLHRLTRLLGRCFQIRDDYQNLVSADYTKQKGFCEDLDEGKWSLALIHMISHMALLNVLSTGRKHGGMTLEQKQFVLDIIEEEKSLDYTRSVMMDLHVQLRAEIGRIEILLDSPNPAMRLLLELL 7kj8 A 1.9 BS02 210 A 1 D99 R194 N240 S244 K247 E248 R338 Y339 D85 R180 N226 S230 K233 E234 R324 Y325 F95 F96 D99 D103 R179 R194 N240 S244 K247 E248 G251 F332 H333 F81 F82 D85 D89 R165 R180 N226 S230 K233 E234 G237 F318 H319 4.2.3.37 0016829,0046872,0052680 Q9K499 33270439 405 IAVPPSLRLPVIEAAFPRQLHPYWPKLQETTRTWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGAPDEVLQAIADYSAWFFVWDDRHDRDIVHGRAGAWRRLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFARHFHTVIEAYDREFHNRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKHPAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVRRRVEECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVN 8su1 A 1.37 BS02 210 A 1 D99 R194 N240 S244 K247 E248 R338 Y339 D84 R179 N225 S229 K232 E233 R323 Y324 4.2.3.37 0016829,0046872,0052680 Q9K499 37449555 405 AVPPSLRLPVIEAAFPRQLHPYWPKLQETTRTWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGAPDEVLQAIADYSAWFHVWDDRHDRDIVHGRAGAWRRLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFARHFHTVIEAYDREFHNRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKHPAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVRRRVEECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFSSVYWFHHESGRYMVDSWDDRSTPPYVNN