2ohk A 2.2 BS01 1SQ A 1 D32 Y71 D228 T231 D34 Y73 D220 T223 D32 S35 N37 A39 Y71 D228 T231 D34 S37 N39 A41 Y73 D220 T223 3.4.23.46 0004190,0006508,0016020 -logKd/Ki=2.70, IC50~2000uM IC50=2000000nM P56817 17315856 390 FVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYN 3kpw A 2.4 BS02 1SQ A 1 Y35 N39 Y40 K57 F182 V269 Y12 N16 Y17 K34 F159 V246 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Kd=14uM -logKd/Ki=4.85, Kd=14uM P11086 20642456 290 ASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKV 3kpw B 2.4 BS02 1SQ B 1 Y35 N39 R44 K57 F182 E219 D267 V269 Y22 N26 R31 K44 F169 E206 D254 V256 2.1.1.28 0004603,0005515,0005829,0008168,0032259,0042418,0042423 Kd=14uM P11086 20642456 290 PDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVG 4yuy A 1.58 BS02 1SQ A 1 I63 Q64 Y73 Q201 I62 Q63 Y72 Q200 2.5.1.16 0003824,0004766,0006596,0016740 ic50=460uM -logKd/Ki=3.34, IC50=460uM Q4DA73 26327378 502 PGSELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuy B 1.58 BS02 1SQ B 1 I63 Q64 Y73 Q201 T236 I63 Q64 Y73 Q201 T236 2.5.1.16 0003824,0004766,0006596,0016740 ic50=460uM Q4DA73 26327378 502 MPGSELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTDPAGPASKLFGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHIN 5aqs A 2.0 BS01 1SQ A 1 R272 G339 R342 R273 G340 R343 D10 K71 E175 D199 D11 K72 E176 D200 3.6.4.10 0005524,0140662 P11142 27708405 1382 SMSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILS 5aqs C 2.0 BS01 1SQ C 1 R272 S275 G339 S340 R342 R269 S272 G336 S337 R339 D10 K71 E175 D199 D7 K68 E172 D196 3.6.4.10 0005524,0140662 P11142 27708405 1382 GPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILS 5ru8 A 1.0 BS01 1SQ A 1 I23 V49 A154 F156 I21 V47 A152 F154 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33853786 201 VNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFL 5rvp A 1.04 BS01 1SQ A 1 D22 I23 V49 A154 D20 I21 V47 A152 2.1.1.56,2.1.1.57,2.7.7.48,2.7.7.50,3.1.13.-,3.4.19.12,3.4.22.-,3.4.22.69,3.6.4.12,3.6.4.13,4.6.1.- P0DTD1 33853786 201 VNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNVYLAVFDKNLYDKLVSSFLE 7axw A 1.69 BS02 1SQ A 1 V57 A70 M120 Y122 V123 L173 T183 F327 V58 A71 M121 Y123 V124 L174 T184 F328 2.7.11.11 0000287,0001669,0001707,0001843,0004672,0004674,0004679,0004691,0004712,0005524,0005634,0005737,0005739,0005813,0005829,0005886,0005930,0005952,0006397,0006468,0006611,0007189,0007193,0010737,0016310,0016607,0018105,0019901,0019904,0030145,0031594,0031625,0032024,0034237,0034605,0036126,0044853,0045542,0045667,0045722,0045879,0046827,0048240,0048471,0050804,0051726,0061136,0070417,0070613,0071333,0071374,0071377,0097546,0098794,0098978,0099170,0106310,1904262,1904539,1990044,2000810 P25321 401 GHMGNAAAAKKGSEQESVKEFLAKAKEEFLKKWESPNTAQLDHFDRIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFTEF 7h9g A 1.53 BS01 1SQ A 1 D10 I11 V33 R144 D13 I14 V36 R147 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 210 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h9g A 1.53 BS02 1SQ A 2 M9 D10 M12 D13 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 211 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h9g B 1.53 BS01 1SQ B 1 G32 V33 C143 R144 G35 V36 C146 R147 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 205 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h9g C 1.53 BS01 1SQ C 1 R8 M9 D10 R11 M12 D13 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 206 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h9g C 1.53 BS02 1SQ C 2 D10 G32 V33 R144 D13 G35 V36 R147 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 207 GAMAPSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h9g D 1.53 BS01 1SQ D 1 R8 M9 D10 R144 R7 M8 D9 R143 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 206 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT 7h9g D 1.53 BS02 1SQ D 2 D10 I11 G32 V33 R144 D9 I10 G31 V32 R143 2.1.1.-,2.7.7.-,2.7.7.19,2.7.7.48,3.1.3.84,3.4.22.-,3.6.1.15,3.6.1.74,3.6.4.13 Q8JUX6 207 PSYRVKRMDIAKNDEECVVNAANPRGLPGDGVCKAVYKKWPESFKNSATPVGTAKTVMCGTYPVIHAVGPNFSNYTESEGDRELAAAYREVAKEVTRLGVNSVAIPLLSTGVYSGGKDRLTQSLNHLFTAMDSTDADVVIYCRDKEWEKKISEAIQMRT