4knb A 2.4 BS01 1RU A 1 A1108 L1140 Y1159 M1160 K1161 M1211 Y1230 A40 L69 Y88 M89 K90 M140 Y159 D1204 A1206 R1208 N1209 D1222 A1243 D133 A135 R137 N138 D151 A172 2.7.10.1 0004672,0004713,0005524,0006468 ic50=0.047uM -logKd/Ki=7.33, IC50=0.047uM IC50=47nM P08581 23773865 1401 QAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLKIHCAVKSLTDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTF 4knb B 2.4 BS01 1RU B 1 I1084 A1108 Y1159 M1160 K1161 M1211 A1221 Y1230 I18 A37 Y76 M77 K78 M128 A138 Y147 D1204 A1206 R1208 N1209 D1222 D121 A123 R125 N126 D139 2.7.10.1 0004672,0004713,0005524,0006468 ic50=0.047uM IC50=47nM P08581 23773865 1401 QHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLKIHCAVKSIGEVSQFLTEGIIMKDFSHPNVLSLLGICPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG 4knb C 2.4 BS01 1RU C 1 I1084 A1108 Y1159 M1160 K1161 G1163 M1211 Y1230 I25 A42 Y86 M87 K88 G90 M138 Y157 D1204 A1206 R1208 N1209 D1222 A1243 D131 A133 R135 N136 D149 A168 2.7.10.1 0004672,0004713,0005524,0006468 ic50=0.047uM IC50=47nM P08581 23773865 1401 PELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLIHCAVKSLNRIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG 4knb D 2.4 BS01 1RU D 1 A1108 L1157 Y1159 M1160 K1161 M1211 A43 L86 Y88 M89 K90 M140 D1204 A1206 R1208 N1209 D1222 D133 A135 R137 N138 D151 2.7.10.1 0004672,0004713,0005524,0006468 ic50=0.047uM IC50=47nM P08581 23773865 1401 QAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDGKKIHCAVKSLDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPITVYLLQGRRLLQCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIG