4kfo A 1.6 BS01 1QS A 1 Y188 H191 F193 R196 D219 V242 A244 R311 I351 Y173 H176 F178 R181 D204 V227 A229 R296 I336 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 IC50=5.0nM, EC50=1.1nM P43490 23617784 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4kfo A 1.6 BS02 1QS B 1 D16 Y18 D9 Y11 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 IC50=5.0nM, EC50=1.1nM P43490 23617784 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4kfo B 1.6 BS01 1QS A 1 D16 Y18 D9 Y11 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 IC50=5.0nM, EC50=1.1nM P43490 23617784 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4kfo B 1.6 BS02 1QS B 1 Y188 H191 F193 R196 D219 V242 A244 I309 R311 I351 Y172 H175 F177 R180 D203 V226 A228 I293 R295 I335 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 IC50=5.0nM, EC50=1.1nM P43490 23617784 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIEL 4o28 A 2.0 BS01 1QS A 1 H191 F193 R196 D219 V242 A244 R311 I351 H173 F175 R178 D201 V224 A226 R293 I333 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 ic50=0.029uM -logKd/Ki=7.54, IC50=29nM IC50=5.0nM, EC50=1.1nM P43490 25285661 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNFREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4o28 A 2.0 BS04 1QS B 1 D16 Y18 D9 Y11 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 ic50=0.029uM -logKd/Ki=7.54, IC50=29nM IC50=5.0nM, EC50=1.1nM P43490 25285661 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNFREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4o28 B 2.0 BS01 1QS A 1 D16 Y18 D9 Y11 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 ic50=0.029uM -logKd/Ki=7.54, IC50=29nM IC50=5.0nM, EC50=1.1nM P43490 25285661 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNFREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE 4o28 B 2.0 BS02 1QS B 1 H191 F193 R196 D219 V242 A244 P273 R311 I351 H174 F176 R179 D202 V225 A227 P256 R294 I334 2.4.2.12 0005125,0005515,0005576,0005615,0005634,0005737,0005829,0007165,0007267,0007623,0008284,0008286,0009435,0016607,0016757,0019363,0030054,0032922,0034356,0042802,0045944,0047280,0048511,0051770,0060612,0070062 ic50=0.029uM -logKd/Ki=7.54, IC50=29nM IC50=5.0nM, EC50=1.1nM P43490 25285661 601 EFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNFREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELE